Posted by admin on Jun 30, 2021 in |
Azadirachta Indica has always been known to be the bestowed with good health for many centuries in India. It has been found that the Neem is native to Asian countries. There are three major active components in A. indica, namely nimbin, nimbidin, and nimbiene. The compound nimbidin was isolated by chromatographic techniques. A. indica leaves extract was prepared, and the phytochemical analysis was conducted, and the phytochemical screening manifested the presence of alkaloids, flavonoids, reducing sugar, phenol, saponins and cardiac glycoside in the neem extract. Then qualitative phytochemical analysis was conducted for flavonoids, alkaloids, saponins, and phenol. Plant sources are considered the major active source of antioxidant molecules for a long time in the history of humankind. In the current study, the anti-bacterial properties of Neem have been tested against gram-positive bacteria, namely, Staphylococcus aureus, Bacillus subtilis, and gram-negative bacteria, namely, Escherichia coli Pseudomonas aeruginosa, Klebsiella pneumoniae, and proteus vulgaris. Chloramphenicol was used as a standard to analyze the effect of the nimbidin compound. The compounds obtained from plants...
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Posted by admin on Jun 30, 2021 in |
Succinimide and its derivatives are important substitutes of many medicinal compounds in the pharmaceutical field. One of the essential objectives in heterocyclic and medicinal chemistry is the synthesis of molecules having importance as therapeutic agents. Heterocyclic compounds and their derivatives contain an imide ring that can easily cross biological membranes in-vivo. Mannich reactions are one of the fundamental methods of C-C bond forming reactions in organic synthesis and withstand a diversity of functional groups. In view of this, the Mannich base1-((2,5-dioxopyrrolidin-1-yl)phenyl)methyl)thiourea and a few of its transition metal complexes with Mn(II) and Co(II) have been synthesized. The newly synthesized ligand and its metal complexes have been characterized by elemental analysis, molar conductance and FT-IR, UV-Visible NMR, Mass spectral studies, and magnetic measure-ments. The ligand and the corresponding metal complexes were screened for their antibacterial and antifungal activities. The metal complexes have shown marked activity against selected microorganisms than the...
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Posted by admin on Jun 30, 2021 in |
Background: Phytochemical profile and antioxidant studies are based on exploring plants for their use in the development of novel therapeutic drugs. Oroxylum indicum (OI), a valuable medicinal plant is native to India, found mainly in the Himalayan foothills and the Western Ghats. It has been used by traditional medicinal practitioners for a variety of ailments and is categorized as vulnerable medicinal plant by the government of India. Objectives: The present study was carried out to evaluate the phytochemical profile and antioxidant potential OI stem bark ethanol extracts. Methods: Phytochemical profiling and in-vitro antioxidant potential of stem bark were determined using standard protocols. The crude extract was subjected to LC-MS analysis for the identification of bioactive compounds. Results: The phytochemical analysis revealed the presence of compounds, namely glycosides, alkaloids, flavonoids, and tannins. At various concentrations tested, the increase in the free radical scavenging activity was observed with an increase in the concentration of extracts. The reducing power of the extract increased in a dose-dependent manner with an increase in concentration....
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Posted by admin on Jun 30, 2021 in |
Anxiety disorders are among the most prevalent and high-cost diseases. Medicinal plants are a very good option to treat, and several have shown the ability to reduce anxiety. We report here the effect of A. gratissima var. gratissima (Agg) on behavior and anxiety in mice. The methanol extract of leaves was tested in order to verify the safety, effect on sleeping time and behavior. Anxiety was tested through the Open field, Hole board, and elevated plus maze tests, with 50, 100, 200, and 400 mg/kg of Agg, and diazepam as positive control drugs. The results showed that A. gratissima var. gratissima did not cause signs of toxicity or sedative effect, and the general behavior of mice was not altered with any dose. All doses of Agg and diazepam, after the mice were submitted to the Open field and Hole board, evidenced a significant increase in ambulation, and a significant decrease in immobility time, related to the control group. On Hole board, a significant increase in number and time spent...
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Posted by admin on Jun 30, 2021 in |
The objective of research work is to formulate a venlafaxine HCl containing medicated chewing gum that has greater bioavailability and compliances than conventional treatment strategies. The four different formulations were prepared after some trial batches, containing different concentrations of the gum base and sucrose (MCG- I- MCG- IV). These batches were optimized on basis of softness and sweetness. Batch MCG- II was found to be optimized containing 60% gum base and 15% of sucrose. Further batches were characterized on basis of Physical characterization, texture analysis, drug content and in-vitro drug release. All batches show good color, softness, and taste. Drug content was found out in a range of 98.43- 99.24%. The in-vitro drug release data revealed that MCG- II shows better drug release than other formulations. Medicated chewing gum can be a better choice for the treatment of depression in the coming years, which may provide several benefits to patient....
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