Posted by admin on Jun 30, 2021 in |
A stability-indicating method by UV spectrophotometry has been developed for the specific determination of Amorolfine HCl in bulk in the presence of its degraded products. The method is simple, accurate, precise, and robust. Experiments were designed for determining linearity, the limit of detection and quantitation, accuracy, precision, and specificity of this analytical method as per the International Organization for Standardization guidelines. The drug substance was exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were analyzed using the proposed method to demonstrate the specificity of the method. The proposed method was found to be linear in the concentration ranges from 2-20µg/ml with the linear correlation coefficient of R2= 0.990, and the mean recovery was 95.59 % at a detection wavelength of 215 nm. Although the degradation products of stressed conditions had not been identified, the method had been able to detect the changes due to stress conditions. The stated method can be used as a stability-indicating method with a high degree of linearity, accuracy, and...
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Posted by admin on Jun 30, 2021 in |
Urolithiasis is a common urological disorder responsible for serious human affliction and cost to society with a high recurrence rate. The aim of the present study was to systematically evaluate the leaf extract of Citrus medica using suitable in-vitro and in-vivo models to provide scientific evidence for its antilithiatic activity. Cystone has been suggested to be beneficial in urolithiasis, as it corrects the crystalloid, colloid stability. It is evaluated that flavonoids, triterpenoids and saponins from different plants resulted in the antilithiatic activity. To explore the effect of Citrus medica on sodium oxalate crystallization, in-vitro assays like crystal nucleation and aggregation were performed. The biochemical parameters like calcium, oxalate, magnesium, phosphate, sodium, and potassium were evaluated in urine, serum, and kidney homogenates. Histopathological studies were also done to confirm the biochemical findings. In-vitro experiments with Citrus medica showed concentration-dependent inhibition of sodium oxalate nucleation and aggregation. In the in-vivo model, Citrus medica reduced both sodium and oxalate supersaturation in urine, serum, and deposition in the kidney. The biochemical results were...
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Posted by admin on Jun 30, 2021 in |
Objective: The key objective of the study is to evaluate the Anti-Alzheimer activity of methanolic extracts of buchnania Lanzan leaves by Aluminum Chloride induced Alzheimer’s. Buchanania lanzan Spreng a well-known forest plant of the family Anacardiaceae. It is reported to have numerous uses in the indigenous system of medicine in India. Material and Methods: Albino Wistar rats were administered with AlCl3 at a dose of 4.2 mg/kg/day i.p. for 4 weeks. Experimental rats were given Buchnania Lanzan Leaf extract in two different doses of 200 mg and 400 mg/kg/day orally 1hr before the AlCl3 administration for 4 weeks. Learning and memory parameters were evaluated using elevated plus maze (EPM), Radial Arm Maze, and T Maze paradigms. Results: The preliminary phytochemical investigation of Buchnania Lanzan Extract showed the presence of carbohydrates, alkaloids, flavonoids, phenols, tannins, saponins. In this study, Buchnania lanzan leaves extract was an administration for 28 days showed significant neuroprotective activity in aluminum chloride-induced rats of cognitive impairment and oxidative stress analyzed by using various behavioral Studies. Conclusion:...
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Posted by admin on Jun 30, 2021 in |
The medicinal plant Ricinus communis is one of the effective plants which offer a solution to several kinds of diseases. Owing to this, the present research aims to review the medicinal properties of one of such common herbal plants, Ricinus communis, its possible role as herbal medicine, and assessment for pharma-covigilance. Related research articles were collected from Google Scholar, Pub Med, Science direct, Scientific information Database, and Scopus. For the present study purpose, using the term Ricinus communis, the castor bean, and castor oil plant in the title of all articles published to 2021 were observed. Phytochemical constituents of R. communis like saponins, flavonoids, alkaloids, steroids, and glucosides. Leaves of the plant have shown the presence of major phenolic compounds. Whereas roots test has presented the Indole-3-acetic. The findings reflect that the plant contains high medicinal benefits, which offer a solution for several kinds of diseases like cancer, diabetes, ulcer and anthelmintic, etc. Also, the plant is anti-inflammatory property of the plant facilitates therapeutic use. Therefore, all parts of...
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Posted by admin on Jun 30, 2021 in |
Scopoletin (7-hydroxy-6-methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. This article is created to provide information regarding the synthesis and pharmacological activity of scopoletin. Scopoletin has been found in many plant species and isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such as Morinda citrifolia, Aegle marmelos, Erycibe obtusifolia Benth, Lasianthus lucidus Blume, Melia azedarach L., Sinomonium acutum, Convolvulus prostratus, and Solanum lyratum, etc. which all possess a number of medicinal properties. Its various pharmacological activities have been reported through a number of investigations. It is reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine. Pharmacological activities that are established in-vivo are antithyroid, antihypertensive, anti-proliferative, anti-inflammatory, neuro-logical, anti-dopaminergic and anti-adrenergic, antidiabetic drug, and anti-hyperuricemic activities. Based on in-vitro studies, scopoletin has pharmacological activities, including an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. From the assorted pharmaco-logical activities of scopoletin, it has the potential to be further...
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