Posted by admin on Jun 30, 2021 in |
Dolutegravir sodium (DTG) is a poorly soluble antiretroviral drug that belongs to BCS class II approved by the FDA for treatment of HIV infections; however, DTG has several shortcomings, including low solubility in water, low oral bioavailability, hepatotoxicity, and instability in an acidic environment. After oral administration, 84% of the dose is excreted from the body in an unchanged form due to its poor solubility. To overcome the above mentioned difficulties, Nano Lipid Carriers (NLCs) are selected as a potential drug delivery system for the present research work. NLC suspension was formulated using melt emulsification sonication technique using a combination of solid lipid (8% w/v), i.e., Glyceryl monostearate (GMS), Gelucire 50/13, Dynasan 118, and liquid lipid Capmul MCM EP along with a blend of Tween 80 and Span 80 as a surfactant, Sodium cholate (0.4 w/v) as surface charge modifier and BHT (0.01%w/v) as a preservative. Response surface methodology using 23 factorial designs with three independent variables, that is, lipid concentration (A), surfactant concentration (B), sonication time (C) was...
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Posted by admin on Jun 30, 2021 in |
Bhavaprakasha is unique in the sense that it shows the slow amalgamation of traditional Indian materiamedica with several new additions which came to the Indian subcontinent through trade and exchanges with foreign civilizations. The Nighantuportion of Bhavaprakasha is an excellent repertoire of herbs and minerals used in Ayurveda. Several plants with properties related to augmentation of ocular function like chakshushya, and to the treatment of eye diseases are mentioned in Bhavaprakashanighantu. Many of these drugs have been subjected to various biomedical in-vitro and in-vivo studies globally over the past decades. They hold the promise of being new therapeutic agents against various ocular diseases like cataracts, diabetic retinopathy, which have no efficient treatment options in existence at the moment. There are more drugs yet to be studied upon. This article is a review of drugs with pharmacological properties related to ocular function or management of eye diseases described in Bhavaprakasha Nighantu and the modern scientific research done on them in recent...
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Posted by admin on Jun 30, 2021 in |
Aim of the present research work was to develop a sensitive, precise, and robust stability-indicating UPLC method for the simultaneous estimation of tipiracil and trifluridine in formulations. The chromatographic separation of a mixture of tipiracil and trifluridine was attained in isocratic method utilizing a mobile phase of 0.1% orthophosphoric acid: acetonitrile in the proportion of 50:50% v/v utilizing a Hibera C18 column which has dimensions of 100 × 2.1 mm, 1.8µ particle size and the flow rate of 1.0 ml/min. The detection system was monitored at 230nm wavelength maximum with 1.5 µl injection volume. The retaining time for trifluridine and tipiracil was achieved at 0.549 min, and 1.251 min. respectively. Tipiracil and trifluridine and their combined drug formulation were exposed to thermal, acidic, oxidative, photolytic, and alkaline conditions. The present method was validated as per the guidelines given by the ICH for specificity, accuracy, sensitivity, linearity, and precision. The developed method was highly sensitive, rapid, precise, and accurate than the earlier reported methods. The total run time was decreased...
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Posted by admin on Jun 30, 2021 in |
Background and Aim: Coronavirus 2019 (COVID-19) is a pervasive emergency affecting 1-5% of children, among whom the majority are with preexisting comorbidities. This commentary aim is to highlight two such prominent childhood comorbidities, i.e., asthma and type 1 diabetes mellitus (T1-DM), with their pathophysiological link to COVID-19. Method: We searched the Google Scholar and PubMed databases till August 15, 2020, and retrieved the data connected to our aim for reviewing. Results: Asthma and T1-DM in children affect the COVID-19 progression due to their interlinked disease mechanisms with infection. Th-2 (T-helper) low endotype asthma and TI-DM connect by decreased ACE (angiotensin-converting enzyme) receptor expression, whereas Th-2 high endotype intensifies the COVID-19 via declining the IFNs (interferons) related anti-viral effect. Addressing these comorbidities therapeutically in this pandemic includes continuity in respective disease control treatment plans with the use of pressurized metered-dose inhaler (pMDI) with a spacer rather than nebulizers or keeping the low incidence of exacerbations by inhaled/oral corticosteroid and/or Montelukast in children with asthma is recommended. In the case of...
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Posted by admin on Jun 30, 2021 in |
Background: Hyperpigmentation (HP) is a common dermatological disease. Indian population presents in a variety of dermatological pigmentation. Effects of Nutrients and metabolites factor are important for skin hyperpigmentation condition. Aims and Objectives: In this study, we aimed to evaluate the status of Haemoglobin, vitamin B12, Ferritin, and TSH levels in people with hyperpig-mentation from a different region of Aravalli district Gujarat, India. Materials and Method: A study based retrospective, prospective and Multi-centric study conducted at the dermatological outpatient clinics at Modasa, Vatrak, Ranasanarea of Aravalli district, Gujarat, India. In this, we studied a total of 70 hyperpigmented patients fulfilling with inclusion criteria. Hyperpigmentation patients correlate with serum vitamin B12; Ferritin, CBC, and TSH during a four-year period from June 2015 to May 2019 were included in the study. Those were diagnosed with following various examinations and tests. A detailed examination was performed with respect to skin hyperpigmentation. Clinical and laboratory data compare with normal control. Student t-test used for statistical analysis. Results: A total of 70 HP patients were investigated...
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