Posted by admin on May 31, 2021 in |
Apremilast, the new PDE4 inhibitor drug, exhibits low solubility and low permeability; therefore, shows variable bioavailability. Effervescent floating tablets of apremilast were developed to sustain the drug release rate by increasing gastric retention time. These tablets were prepared by wet granulation technique, using different polymers like carbopol 934P, hydroxypropyl methylcellulose K4M, tragacanth and sodium alginate, either alone or in combination. Prepared tablets were characterized for physical parameters like floating capacity, hardness, % weight variation, friability, and content uniformity. Additionally, tablets were evaluated for in vitro release characteristics for 24 h. Results of this study exhibited good physical properties within the limit of acceptance. Batches prepared by carbo-pol 934P did not show any initial burst release as compared to other polymers. When polymer concentrations were increased drug release rate was decreased. Drug release from the tablets was followed by zero-order controlled release. Sodium alginate/ tragacanth and HPMC K4 in 1:3 ratio exhibited best drug release for 24 h. Carbopol batches (1:3 ratio ) showed very first floating lag time (52...
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Posted by admin on May 31, 2021 in |
In the present study, we evaluated the Anti-parkinson’s activity of Cyamopsis tetragonoloba methanol plant pod extract by Haloperidol Induced Catalepsy and Tacrine induced vacuous jaw movements for behavioral parameters and in-vivo assays to estimate neurochemical parameters like (GSH, LPO, and SOD). The behavioral analysis performed using Haloperidol Induced Catalepsy produces Parkinson’s disease (PD) like symptoms, has been shown to reduce the catalepsy significantly (P<0.001) with Cyamopsis tetragonoloba methanol plant pod extract (200 and 400 mg/kg) doses. Tacrine-induced jaw movements and bursts symptoms closely resembling the PD symptoms shown to reduce treatment with plant extract and helped to manage the uncontrolled movements. The biochemical parameters like Lipid peroxidation (LPO), Glutathione (GSH), and Superoxide dismutase (SOD) were assessed using control, standard, and 200 and 400 mg/kg Cyamopsis tetragonoloba extract, results revealed that rats treated with plant extracts had increased levels of GSH and SOD which was found to be lower in the patients of PD and further plant extract analysis found efficient in reducing the LPO activity which helps to decrease...
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Posted by admin on May 31, 2021 in |
Covid-19 pandemic has enforced the entire scientific community to work together and find a solution for the adversity the whole world is facing. This has called for immediate actions, and the most common point of discussion and rapid way to tackle this is to repurpose the previously approved molecules and check their activity against this virus. The role of computational techniques has paved the way for rapid screening of molecules so as to provide us an insight on to designing drugs to inhibit this virus. Our group has screened the Dug bank database containing 8696 molecules. These molecules were screened using three tired molecular docking protocol. We utilized 5R82 as our target structure for the main protease enzyme of SARS-CoV-2, as it was the best available structure in Protein Data Bank. After screening the database, we obtained 200 molecules having docking scores better than the standard molecules (Ritonavir and Lopinavir). Eventually, after detailed analysis, we selected three molecules DB02307, DB04226, and DB01713, for Molecular dynamics simulation study and also...
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Posted by admin on May 31, 2021 in |
Tea tree oil, an essential oil, has claims for analgesic, antimicrobial, antiseptic, and anti-inflammatory activity. Its complex composition is governed by ISO 4730:2017. It is extensively used in skin and hair care cosmeceuticals, often in combination with neem seed oil. Neem seed oil has potent antimicrobial, skin rejuvenating, and conditioning action attributed to the presence of micro constituents and complex lipid composition of triglycerides, diglycerides, and monoglycerides of both saturated and unsaturated fatty acids. Although few methods are available for estimation of individual oils, simple spectrophotometric methods suitable for routine determination of either oil or for simultaneous estimation of both the oils are not reported. A novel, simple, validated UV spectrophotometric method for simultaneous estimation of tea tree oil and neem seed oil in bulk and cosmeceutical formulation has been developed after optimization and validation of UV spectrophotometric method for individual estimation of oils. The method relies on the measurement of absorbance at 267nm and 284nm, λmax of tea tree oil, and neem seed oil, respectively. Linearity is established...
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Posted by admin on May 31, 2021 in |
Next-generation printing or commonly known as three-dimensional (3D) printing (3DP), is a fabrication process of construction of a 3D object using a computer-aided design or digital 3D model. The 3D object is created layer by layer by depositing, joining, or solidifying a feedstock material such as thermoplastic polymer under the control of a computer-designed program. It is considered the latest technology that has the potential to address complex medical and pharmaceutical problems, such as prototyping essential medical devices, equipment, and novel drug delivery systems. The ability of 3DP to produce medications with accurate specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes, sizes, and textures, in a limited time period. In spite of many potential medical and economic benefits of 3DP, some technical and regulatory challenges are associated with the widespread application of 3DPin the pharmaceutical sector; those need to be addressed by proper research so that the benefit of...
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