Posted by admin on May 31, 2021 in |
The aim of the study was to evaluate the anti-diabetic and antioxidant effects of aqueous extract of Phaseolus vulgaris L. seeds in normal and streptozotocin (STZ) induced diabetic rats. Female Albino Wistar rats were divided into 6 groups of 6 rats; each was assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ (55 mg/kg body weight). Phaseolus vulgaris L. extract at the doses of 100, 200, and 300 mg/kg body weight and glibenclamide (600 μg/kg b.w.) by intragastric tubation orally administered to both diabetic animals for a period of 30 days. After completion of experimental length, blood serum, liver, and exocrine gland were used for evaluating organic chemistry. Oral administration of Phaseolus vulgaris L. seeds significantly reduced elevated serum glucose, renal, liver function levels and significantly increased serum insulin and body weight as well as improved lipid profile due to...
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Posted by admin on May 31, 2021 in |
Objective: To study the influence of paracetamol on analgesia when given separately with low dose etoricoxib for treatment of acute pain in mice. Materials and methods: Animals were divided into 6 groups consisting of six animals in each group. Dose was calculated by using conversion factor for mice from human dose. Group I, II, III and IV received 2% Gum acacia 10ml/kg, paracetamol 84.5mg/kg, etoricoxib 3.9 mg/kg and 7.8 mg/kg respectively. Group V and VI received etoricoxib 3.9 mg/kg + paracetamol 42.25mg/kg and etoricoxib 3.9 mg/kg + Paracetamol 84.50 mg/kg respectively. Group II, V and VI were administered rescue paracetamol at 6 h. Acetic acid induced writhing test and hot plate method were used to evaluate immediate and delayed analgesic activity respectively. Results: After 1 h low dose paracetamol in combination with low dose etoricoxib showed significant (P<0.05) analgesic activity as compared to etoricoxib low and paracetamol high dose when used alone and comparable analgesia as compared to etoricoxib high dose when used alone. High dose paracetamol with low...
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Posted by admin on May 31, 2021 in |
The aim of the present study was to formulate and evaluate Budesonide proniosomes for enhancement of solubility and bioavailability. To develop and evaluate budesonide proniosomes was the main objective of this research work. For the preparation of proniosomes slurry, a method was used using different ratios of (cholesterol: surfactant) (1:1.5) with the help of carriers. For optimization of formulation Box-Behnken Design was used in that concentration of span 60, cholesterol, and maltodextrin. The prepared proniosomes were evaluated for particle size, entrapment efficiency, and in-vitro drug release (up to 6 h). Particle size, entrapment efficiency, and drug release of optimized batch (F14) were found to be 220.3 nm, 81.42%, and 30.71%, respectively. The data were fitted into a zero order model, and the correlation value found to be 0.952, indicating controlled release. Transformation of niosomes from proniosomes and morphology study of the optimized batch was studied by Inverted Microscopy and Transmission Electron Microscopy, etc. Statistical analysis of ex-vivo permeation enhancement assessed from the flux, permeability coefficient, and enhancement ratio was...
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Posted by admin on May 31, 2021 in |
Herbs are the main source of Ayurvedic formulations. Polyherbalism concept of Ayurveda enables fortified therapeutic effect when compared to single herb. The potency of polyherbal formulations depends on their ingredients. Plants tend to vary in their efficacy due to the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture content. The quality of polyherbal formulations depends on factors like selecting the raw material, habitat, season, harvesting conditions, method of storage, and pharmaceutical processing. Hence the evaluation parameters for polyherbal formulations should be based on chemical, physical, microbiological, therapeutic and toxicological assessment. Standardization for each formulation is unique. The monograph thus prepared will be useful to ensure the quality of the pharmaceutical product. Palasha beejadi Choorna (PBC) is a formulation indicated and frequently prescribed as the best choice for krimiroga. It is mentioned in Rasoddaratantra and in the Ayurvedic Formulary of India (AFI). Aims and objective: The objective of the study is to standardize Palasha beejadi choorna of Rasoddaratantra, mentioned in the Ayurvedic Formulary of India. Methodology PBC...
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Posted by admin on May 31, 2021 in |
Worldwide, Tuberculosis (TB) remains the most frequent and important infectious disease caused by Mycobacterium tuberculosis (Mtb). TB Structural Genomics Consortium (TBSGC) reported 79,144 deaths and 26.9 lakh cases in 2019 (WHO). Although tuberculosis is a curable disease, the chances of a cure become slim as the disease becomes multidrug-resistant, and the situation gets even worse as the disease becomes extensively drug-resistant. The emergence of multidrug-resistant varieties of Mycobacterium tuberculosis has led to a search for novel drug targets. The objective of this paper is based on the drug designing for the potential drug target Murd Ligase protein from M. Tuberculosis. This drug target is involved in vital aspects of the pathogen’s metabolism, persistence, virulence, and cell wall biosynthesis. In this study, we have built a homology model of the protein Murd Ligase based on homology technique using SPDBV and further, the model is analyzed with various existing drugs and docking enzyme inhibitors that reveal the structural information for the development of effective anti-tuberculosis drugs using...
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