Posted by admin on Apr 30, 2021 in |
The study evaluates the medicinal efficacy of Solanum capsicoides fruits as an antioxidant. Fruit extracts were prepared using acetone, ethanol, HCl, and water for the measurement of antioxidant potential by reducing power, DPPH radical scavenging activity, and CUPRAC assay and for the spectrophotometric determination of total phenol, flavonoid, anthocyanin, and carotenoid content. Chemical profiling of the fruit extract through GC-MS was also conducted. The total phenolic contents in extracts ranged between 1.2-4.25mg GAE g-1 FW and flavonoid contents in the range of 3.89-22.96mg QE g-1 FW. Among the various solvents used, acetone extract showed maximum antioxidant activity, and the least was observed in the water extract. Correlation coefficient analysis between bioactive compounds and antioxidant property revealed that TPC and TFC were positively and significantly correlated with antioxidant activity. A negative correlation was observed between the pigments, anthocyanins, and carotenoids, with DPPH and CUPRAC activity. The correlation between DPPH radical scavenging activity and carotenoids as well as TFC was not significant. In the case of RP, except carotenoids, all others...
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Posted by admin on Apr 30, 2021 in |
The genus Leea distributed majorly in tropical and subtropical regions of Asia, Africa, and Madagascar, belongs to the family Leeaceae. It comprises 36 species that are used worldwide for different medicinal purposes. In this decade, research interests in the genus Leea have grown in the fields of systematics, phylogenetic studies, analytical chemistry, identification and isolation of active metabolites, pharmacology, and phytochemistry. A wide range of phytochemicals with a variety of pharmacological activities were found to be possessed by different species of the Leea family, flavonoids, phenolics, triterpenoids, and tannins being the major ones. Different plant parts are claimed to be used for the treatment of human and animal ailments. Unlike members of Vitaceae, Leeaceae members (Leea species) do not form tendrils and include erect herbs, shrubs and trees but have shared features such as raphides, minute droplets of plant sap called pearl glands, phloem plastids, common corolla-stamen primordia, as well as similar wood and testa anatomy similar to Vitaceae family. This review reveals new insights on the genus Leea...
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Posted by admin on Apr 30, 2021 in |
The prevalence of cancer is drastically increasing among cardamom farmers using chemical pesticides in Idukki district. The chemicals, mainly Organochlorine and organophosphates, result in various disease conditions. The main aim of the study was to explore the prevalence of cancer and other disease conditions among farmers and other people who were exposed to chemical pesticides. A community-based epidemiological study was conducted among cardamom farmers and people exposed to the chemical pesticides by using a pre-structured questionnaire containing socio-demographic details, information regarding chemicals, and their disease status. Descriptive and analytical statistics were applied for data analysis. A total of 237 members had interviewed. Among them, 47 were cancer patients, and 169 had comorbidities and other disease conditions. About 54 were suspected of cancer as per symptoms. Among cancers, breast cancer (36.17%) was detected as the major type, and the majority were females (23.3%). The majority of the patients 26 (28.3%) were worked for more than 20 years in the field. The majority of patients with cancer (22.3%) were not taken...
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Posted by admin on Apr 30, 2021 in |
Purslane (Portulaca oleracea L.) is an herbaceous weed belonging to the family Portulacaceae. It has high nutritional value and possesses potent pharmacological actions such as analgesic, hepatoprotective, anti-inflammatory, wound healing, bronchodilator, neuropharmacological, anti-diabetic, antioxidant and antihypertensive. It is listed in a World Health Organization database because of these many health benefits. From the phytochemical investigations it is revealed that Purslane has the presence of antioxidants (vitamins A and C, α- tocopherol, β-carotene, and glutathione), linolenic acid and omega-3 fatty acids. This study aimed was to identify the linolenic acid content of Purslane extracts using HPTLC. In this study, three different solvents (Petroleum ether, methanol, and water) were used for the extraction of dried leaves and were compared. Successive solvent extraction was carried out with increasing polarity of the solvents. The extracts were analyzed for the identification of linolenic acid, and its concentration was determined using HPTLC. For HPTLC analysis, the mobile phase comprising of chloroform: methanol: water: ammonia (65:24:4:0.4 v/v/v/v) was used and the Rf value for standard linolenic acid...
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Posted by admin on Mar 31, 2021 in |
The aim of this investigation was to re-evaluate the in-vitro mutagenic, genotoxic, and aneugenic potential of omeprazole through the Ames test, comet (SCGE), and cytokinesis-block micronucleus assays (CBMN), as previous reports on the mutagenic and genotoxic effects of omeprazole are scarce and inconclusive. The results of this study indicated a negative mutagenic effect through the Ames test. Comet assay endpoints such as tail length, tail intensity, and tail moment showed a mild genotoxic effect with dose-dependence. The CBMN assay endpoints were implemented according to the requirements for in-vitro evaluation of genotoxicity after 4 h of exposure, with or without metabolic activation. Endpoints, such as binucleated cells with micronuclei (BNMN), total micronuclei (MN), arrested metaphasis (AM), nuclear buds (NB), nucleoplasmic bridges (NPB), and necrotic cells (NC), showed a dose-dependent effect. The number of apoptotic cells (AP) showed a statistically significant increase compare to the control value but was without dose-dependence. This in-vitro study suggests omeprazole exhibits mild genotoxic and aneugenic...
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