Posted by admin on Nov 30, 2022 in |
The recent emergence of the Omicron variant (B.1.1.529) of SARS‐CoV‐2 has added alarm to the eternal flame of the global COVID‐19 pandemic. Omicron was first identified in Botswana in November 2021. The omicron is thought to be at least three times more infectious than the previous variants. Omicron can cause diseases varying from asymptomatic, mild, and severe infection and people have died from omicron in a second pandemic wave that occurred in March-May 2021. This variant has been detected in more than 77 countries worldwide as per WHO until January 2022. The spike protein is the target of most COVID-19 vaccines and is what the virus uses to unlock access to our body’s immune cells, many of which (69–70del (deletion), T95I, G142D/143–145del, K417N, N679K, T478K, N501Y, N655Y, and P681H) overlap with Alpha, Beta, Gamma, or Delta variants. Some spike protein mutations include A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE G339D, S371L, S373P, S375F, etc. Remarkable mutations in the furin cleavage site may increase transmissibility and replication as in Alpha (P681H)...
Read More
Posted by admin on Oct 31, 2022 in |
Background: Currently, 23 drugs for treating drug-susceptible TB, MDR-TB, or latent TB infection are in Phase I, II, or III trials. Bedaquiline, Delamanid and Pretomanid are new approved drugs. Still, TB is more prevalent in many countries. So, ideally, the countries facing this problem should do extensive research. Aim: The aim of our study is to find the number of studies, their design, sponsorship, phase, and state-wise distribution of studies on tuberculosis in India. Methods: After receiving an exemption from the ethics committee. The search term used in the “Trial Search” section of the CTRI site was “tuberculosis” or “TB” and the variables were captured and analyzed by using descriptive statistics in SPSS 26. Result: A total 134 studies were found. 61.9% of studies were interventional type, 78% were institute funded, 59 studies involved drug use mostly in combination, 104 studies were conducted at a single center, and 45 studies took sample sizes ranging up to 100. Only 37% of studies’ completion report was found. 18% of studies were...
Read More
Posted by admin on Oct 31, 2022 in |
The objective of present study was to develop extended release microspheres of quetiapine fumarate using Eudragit RS 100 and Eudragit RL100 to reduce the dosing frequency. The quetiapine fumarate-loaded Eudragit microspheres were formulated by a solvent evaporation method. A 32 factorial design was employed to study the effect of concentration of sodium lauryl sulfate (SLS) and drug: polymer ratio on percentage yield, percentage entrapment efficiency, particle size, and % in-vitro drug release at 10 h. Drug excipients compatibility study by DSC showed no interaction between drug and excipients. The entrapment efficiency was found to be 40.56 ±1.32 % to 72.66 ±2.13 %, and the particle size range was 165±3.51 µm to 243±3.05 µm. In-vitro drug release of quetiapine fumarate microspheres showed a sustained release up to 24 h. Concentration of SLS and drug: polymer ratio had significant effect on % yield, % entrapment efficiency, particle size and % in-vitro drug release. From all parameters and experimental design evaluation it was concluded that drug release rate decreased with an increase...
Read More
Posted by admin on Oct 31, 2022 in |
Dexibuprofen is a Non-Steroidal Anti-Inflammatory Drug. It indicated short-term management of mild to moderately severe acute pain, dental pain, dysmenorrhoea, muscular pain and osteoarthritis. In the prevailing work, studies have been carried out on the preparation and in-vitro characterization of matrix tablets of dexibuprofen using different polymers like hydrophilic and hydrophobic. Different formulations had been prepared by wet granulation method using various release retarding polymers like methylcellulose, xanthan gum, and sodium carboxymethyl cellulose. Water-soluble surfactant sodium lauryl sulfate was employed to enhance the solubility of the dexibuprofen. Drug-excipients compatibility became performed by way of FTIR. Different parameters were evaluated for hardness, thickness, friability, drug content material, and in-vitro drug release. The excellent consequences were determined in terms of physicochemical parameters. The 10 numbers of formulations have been discovered to display the highest drug release of the drug. Mathematical analysis of the release kinetics has been accomplished to determine the mechanism of drug release. In-vitro release records have been fitted into diverse models to envision the kinetic of drug...
Read More
Posted by admin on Oct 31, 2022 in |
Heavy metal toxicity has been a subject of concern for the past few decades. Due to the emerging awareness about the detrimental health hazards and adverse effects across all the levels of any ecosystem, the removal of heavy metals (HM) from contaminated water systems and soil has gained the profound attention of the scientific community for the last couple of decades. Living and dead cells of biological organisms have found to have capable of retaining the harmful HMs substantially from aqueous and solid matrix. This review encompasses the efficacy of cyan bacterial cells in removing HMs from contaminated water and wastewaters. The different strains collected from different sources which are capable of removing specific species have been discussed along with the biotic and biotic factors affecting the process have been assessed. Also, the mechanism of toxicity and removal of HMs through biosorption and bioaccumulation by these cells have been taken into consideration. The thorough knowledge of the cyanobacterial removal of HMs can be a solution towards sustainable, cost-effective green...
Read More
