Posted by admin on Dec 31, 2021 in |
Objective: The research work aims to formulate and evaluate the Gastro retentive mucoadhesive film of Ritonavir using polymers like HPMC K15M, Polyvinyl alcohol, and PEG 400 as a plasticizer by solvent casting method for treatment of AIDS. Method: Prepared gastro retentive mucoadhesive films were evaluated for various parameters such as in-vitro unfolding behavior of film, Folding endurance, Percent swelling, Drug content, and in-vitro drug release studies. Results: The release rate of the gastro retentive mucoadhesive films of Ritonavir was found to obey Korsmeyer-Peppas kinetics. After analysis of different evaluation parameters and drug release kinetics. Conclusion: Formulation code F4 was selected as a promising formulation for delivery of Ritonavir as a muco-adhesive Gastro retentive film with required in-vitro parameters 99.08% drug release at 12th...
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Posted by admin on Dec 31, 2021 in |
The application of mathematically based prognostic software is a rational and promising approach to determining disease prognoses. In our research, we identified indicators as prognostic criteria for the development of atopic dermatitis (AD). Our research involved 260 healthy children and 268 newborns with AD. To select the risk factors for predicting the formation of AD, initially, variation and discriminant analyses were used to identify 50 indicators (out of 109 clinical laboratory indicators) that differed statistically. Then, 28 indicators with a high impact on the final result were selected via disbursement analysis; subsequently, 19 indicators based on specificity and sensitivity were fixed. In the next step, via correlation analysis, we focused on 15 antenatal, intranatal, neonatal, and laboratory risk factors that did not correlate with each other. Based on these indicators, software for the prediction of atopic dermatitis was developed. The software-based on MS EXCEL was developed with the application of theories of probability and “fuzzy logic”, and the Sp and Sn of the test were evaluated accordingly at 78.5±2.5%...
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Posted by admin on Dec 31, 2021 in |
Introduction: Irrational use of drugs is widespread in present-day medical practice. Hence, the present study aimed to analyze the drug prescribing pattern among the patients who visited the Faculty of Dentistry dental clinic, AIMST University. Methods: A retrospective, cross-sectional study was conducted to analyze the drug prescribing pattern of dentists of AIMST University, Kedah, Malaysia. A total of 857 patients’ medical records were scrutinized between January 2018 to March 2018, and only 532 patients’ medical records were identified to have drug prescriptions. Patients’ drug prescription data were collected and analyzed using descriptive statistics. Results: Drug prescription books of 532 patients were analyzed. Female patients were greater in number [325(61.09%)]. The most common dental problem was gingivitis [275(28.29%)] followed by dental carries [215(22.12%)], periodontitis [198(20.37%)] and edentulous [157(16.16%)]. A total of 965 drugs were prescribed, with an average number of 1.81 drugs per prescription. The commonest therapeutic class of drug prescribed was NSAIDs [432(44.77)] followed by antimicrobials [309(32.02)]. The percentage of encounters with an antibiotic prescription was higher (32.02%) than...
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Posted by admin on Dec 31, 2021 in |
Momordicinin (MMR) is a major triterpenoid compound from Momordica charantia Linn fruit having antidiabetic potential, whereas glipizide (GPZ) is a well-known molecule in treatment of diabetes mellitus. The primary objective of the study is to develop and validate a simultaneous RP-HPLC method for upcoming pharmacokinetic studies to analyze herb-drug interactions. The study uses the protein precipitation method for plasma sample preparation. Chromatographic separation of GPZ and MMR was well achieved using hypersil gold C18 column (250 × 4.6, 5µm) and mobile phase constituting acetonitrile: phosphate buffer 10 mM with pH 3.5 (40:60, v/v). Quantification was done at wavelength 223 nm. The method was validated as per USFDA guidelines. The developed method showed good linearity over the range of 7-17 µg/ml, and the lower limit of quantifications was found to be 1.89 µg/ml and 1.99 µg/ml for MMR and GPZ, respectively. The extraction and chromatographic separation of both the drugs was found to be robust and reproducible. The %RSD for validation parameters was within the specified limits as per USFDA...
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Posted by admin on Dec 31, 2021 in |
The antibacterial property of three Himalayan Oaks species (Quercus floribunda, Q. leucotrichophora and Q. semecarpifolia) in different solvents against eight gram-positive and gram-negative pathogenic bacteria employing disc diffusion method has been investigated. All the test microorganisms were inhibited significantly by Oaks species at 1000 μg/ml. The MIC and MBC values of each extract (where ZOI ≥ 15 mm) were also determined. Q. semecarpifolia exhibited significantly higher antibacterial activity compared to other species. Solvent systems showed species-specific response for extraction of total content (% yield) of dry extract. Maximum yield was found for ethanol extract (3.59-5.79%). Methanol extract of Q. leucotrichophora showed the highest inhibitory activity against all the tested bacteria (16-23 mm) ZOI, followed by acetone extract (17-23 mm), ethanol extract (15-20 mm). Furthermore, methanol and acetone extracts of Q. leucotrichophora showed significant activity against A. tumefaciens and E. chrysanthemi, with MIC values of 15.6-31.25 μg/ml and MBC values of 15.6-125 μg/ml. Q. semecarpifolia showed its highest antibacterial potential against X. phaseoli and E. chrysanthemi whereas extracts of Q....
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