Posted by admin on Dec 31, 2021 in |
Objective of this article is to review three techniques, routinely used rapid diagnostic tests (lateral flow immune chromatography) versus nucleic acid amplification test (NAT) versus Paper-based microfluidics for DNA diagnostics of Malaria, as diagnostic tests in detecting malarial infection among febrile illnesses, suspected of malaria. The major constraint for implementing NAT as a routine screening technique in India appears to be its high cost per test. There is a need to evaluate the technique and its cost-effectiveness as compared to RDT in the Indian setting as there is a scarcity of literature in this...
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Posted by admin on Dec 31, 2021 in |
This research was focused on the qualitative and quantitative analysis of phytochemicals and evaluation of in-vitro antioxidant and anti-inflammatory activities of three commonly used plant parts in rheumatoid arthritis medications in Ayurveda, namely, the root of Boehmeria nivea, the barks of Gmelina arborea and Oroxylum indicum, using standard methods. Qualitative analysis of each methanol extract confirmed the presence of alkaloids, flavonoids, condensed tannins, polyphenols, triterpenes, sterols, and saponins in varying quantities. The highest total alkaloid content of 108.81 ± 0.54 mg caffeine equivalent per 100 g of the dry weight of plant materials (DW) and the highest total flavonoid content of 268.94 ± 12.62 mg catechin equivalent per 100 g DW were exhibited by the bark extracts of Gmelina arborea and Oroxylum indicum, respectively. The highest total condensed tannin content of 529.34 ± 30.51 mg catechin equivalent per 100 g DW and the highest total phenolic content of 640.34 ± 64.58 mg gallic acid equivalent per 100 g DW were demonstrated by the root extract of Boehmeria nivea. The...
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Posted by admin on Dec 31, 2021 in |
In-silico studies play a very crucial role in medicinal chemistry and synthesis of the lead compound. As we know that 1,4-Dihydropyridine is a versatile molecule, and previous studies have shown that it possesses therapeutic activity in different diseases, such as anticancer, anticonvulsant, anticoagulant, anti-Alzheimer, antitubercular antiulcer. As described by the researchers, 1,4 Dihydropyridine with sulphanilamide substitution possess good antiulcer activity so, here, in our research work, we decided to synthesized 1,4 dihydropyridine derivative by replacement with some other free amine group-containing compound to determine the antiulcer property of 1,4 Dihydropyridine. To keep this in mind, we studied its interaction with receptor site (H+/K+ ATPase pump), which was obtained from protein data bank (PDB) and a series of 1,4-Dihydropyridine hybrid molecule synthesized. The binding of the molecule with receptor site investigated by molecular docking studies and drug-like illness of these compound predicted by using Schrodinger maestro suite 2018-4. Omeprazole and Lansoprazole were used as a standard to validate the docking results. Synthesized molecule characterized by spectroscopic methods and evaluated for...
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Posted by admin on Dec 31, 2021 in |
Molecular object precise healing designed for the malignancy be unrelated as of the predictable therapy, as well as radio healing in conditions of selectivity and specificity target to the malignant tyrosine kinase, is well-thought-out additional shows potential molecular intention for invention and expansion of the new cytotoxic drug molecules. Epidermal growth factor receptor is overexpression irregulation or alteration are experiential in the various types of epithelial type cancer such as non-small cell lung cancer (NSCLC), carcinoma of the breast, colon, etc., in the present research carry out molecular modeling study approaches on quinazolinone derivatives as EGFR Inhibitors with the put of 20 drug molecules will be taken to show the relationship of the structural parameters, a drug like properties by using molinspiration technique and further, molecular docking simulation was done and find the interaction of Ligands active position of EGFR, as well as computational study, was carried out which results in the prediction of pharmacokinetic & bioactivity properties. Moreover, the results of this work afford the information related to...
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Posted by admin on Dec 31, 2021 in |
Background: Beta-glucogallin (BGG) is a tannin precursor naturally found in a variety of plants such as gooseberry, raspberry, amla, etc. BGG was reported to be a potential therapeutic agent in managing a variety of diseases. This investigation was intended to assess whether BGG alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with the cholinergic system and antioxidant effects. Materials and Methods: Two doses of BGG (5 & 10 mg/kg) were tested in the exteroceptive and interoceptive amnesia model: Morris Water Maze test, Elevated plus-maze model, scopolamine-induced amnesia and assessment of motor coordination activity. The assessment of in vitro antioxidant activity by DPPH method and molecular docking analysis was also performed. Results: Pre-treatment with BGG at doses 5 and 10 mg/kg have shown significant anti-amnesia activity in the behavioral models in a dose-dependent manner.BGG at a lower dose did not impact the motor coordination activity of mice; however, at a higher dose, the results did not show a major impact, though the results look statistically...
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