Posted by admin on Oct 31, 2022 in |
Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure for this disease. The present study was commenced to evaluate the in-vivo anti-arthritic effect of polyherbal formulation of selected plants Polygonum glabrum, Canthium dicoccum, Ochna obtusata and Argyreia nervosa. Materials and Methods: In-vivo anti-arthritic activity of the ethanolic extract of different portions capsule formulation F4 investigated orally was assessed using complete Freund’s adjuvant-induced arthritis. Results: In complete Freund’s adjuvant-induced arthritis models, the polyherbal extract formulations significantly (P < 0.001) reduced joint and paw swelling and markedly improved body weight, hematology profile, and parameters in complete Freund’s adjuvant model. Conclusion: It could be concluded that the ethanolic extract of two different formulations holds anti-arthritic potential, supporting its traditional use...
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Posted by admin on Oct 31, 2022 in |
Antibacterial activity of five marine microalgae Isochrysis galbana, Chaetoceros calcitrans, Tetraselmis suecica, Nannochloropsis oculata, Aphanocapsa sp. was studied from Visakhapatnam. The ethanolic extract of T. suecica, C. calcitrans, and N. oculata s howed inhibitory activity against V. harveyi and S. Aureus with inhibition zone between 11.5 and 20mm. The ethanolic extract of I. galbana showed inhibitory activity against S. aureus only with an inhibition zone of 15mm. Among the four extracts, T. suecica showed maximum inhibitory activity against V. harveyi with an inhibition zone of 20mm. The methanolic extract of T. suecica moderately inhibited the growth of V. harveyi and S. aureus with inhibition zones of 11.5 and 11 mm respectively, whereas the extracts of I. Galbana and C. Calcitrans inhibited only V. harveyi with inhibition zones of 10 and 12 mm respectively, but no activity was found against S. aureus, A. hydrophila and E. coli. So, the studied microalgae could be used as a potential source to extract, bioactive marine natural compounds with antibacterial activity....
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Posted by admin on Oct 31, 2022 in |
Leclercia adecarboxylata is a gram-negative bacillus. L. adecarboxylata has been isolated from various environments, such as food and water, and clinical specimens from patients with various diseases and ailments, such as pyelonephritis and sepsis. Although L. adecarboxylata infections are generally treated with β-lactam antibiotics, the emergence of multidrug-resistant strains reported in recent years has presented a major challenge in the clinical treatment of the infections. Thus, I searched for potential candidate compounds for developing new antibiotics that are effective against multidrug-resistant L. adecarboxylata. In a docking simulation performed to extract an inhibitor of the molecular chaperone GroEL, mizoribine was identified as a “hit.”Notably, when L. adecarboxylata was cultured in a mizoribine-containing medium, its growth was inhibited at mizoribine concentrations of ≥0.63 mmol/L. considering these findings, I propose that mizoribine could serve as an effective new therapeutic agent for L. adecarboxylata infection. In the future, it will be necessary to investigate the effects of mizoribine on other bacterial...
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Posted by admin on Oct 31, 2022 in |
The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, triterpenoids, flavonoids, steroids, and phenolic acids which have shown promising therapeutic potential. The hepatoprotective effect was assessed by evaluating the biochemical parameters like serum alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and total bilirubin and histopathological studies of the liver. Rats treated with ethanolic extracts of Alstonia scholaris in the dose of 150 mg/kg and 300 mg/kg, evinced a considerable reduction in CCl4 induced augmented serum enzyme levels (ALT, AST, ALP, and total bilirubin) and also a considerable increase in total protein levels that was lowered by hepatotoxic compound used, comparable with Silymarin (standard drug). Alstonia scholaris was also able to significantly prevent the rise in MDA level as evident by the...
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Posted by admin on Oct 31, 2022 in |
The novel Corona Virus Disease – 19 (COVID-19) is a Contagious disease spreading among Animals and Humans, a Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS CoV2). The First case was identified in Wuhan, China as the disease has unfolded worldwide to the continuing pandemic. It created more infected cases and deaths worldwide, creating an urge for newer drugs of manipulate the Ongoing Pandemic and address the contemporary state of affairs. Remdesivir (GS-5734) has been recognized because the first authorized remedy for intense COVID-19 and has also been recognized to be a novel nucleoside an a log with a large antiviral activity spectrum among RNA viruses which include ebolavirus (EBOV) and the respiratory pathogens Middle East breathing syndrome coronavirus (MERS-CoV), SARS-CoV and SARS-CoV-2. Being first defined in 2016, the drug was derived from an Antiviral library of small molecules intended to target emerging pathogenic RNA viruses. Remdesivir has been discovered to lessen the time to restoration of hospitalized patients who require supplemental oxygen and has a high-quality effect on mortality results...
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