Posted by admin on Oct 31, 2022 in |
Most of the medications currently in use are largely derived from the traditional plants and their products. Lawsonia alba, often known as henna, has a wide range of medicinal uses, from minor infections to cancer and is also used as a hair dye. All of these pharmacological actions and therapeutic uses are because of the presence of numerous secondary metabolites. These were isolated using the GC-MS technique from the aqueous extract of L. alba leaves. The compounds were then analyzed for pharmacokinetics and pharmacodynamics by using SwissADME, OPENBABEL, Swiss target prediction, etc., like software. In the aqueous extract of L. alba, we obtained 91 compounds; out of these 38 were significant, but only 09 compounds were in prominent concentration, and all of these 09 compounds were non-toxic, they are orally absorbable molecules with acceptable lipophilic and hydrophilic nature which were subjected to various software to obtain the target protein that can dock with specific properties of modulating various proteins/receptors/enzymes and these compounds or their derivatives can be considered as...
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Posted by admin on Oct 31, 2022 in |
The main objective of this research work was to formulate and evaluate an Orodispersible tablet of Bisoprolol Fumarate for the treatment of hypertension and coronary artery disease. Formulation was designed using systat software version 13.2. 32 full factorial design was applied, in which two variables were varied at three levels. The tablets of Bisoprolol Fumarate were developed by direct compression method. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, wetting time, content uniformity, disintegration time and in-vitro dissolution. FTIR studies indicated that drug and excipients were compatible. Pre-compression and post-compression parameters were satisfactorily within acceptable limits. The results indicated that concentration of croscarmellose sodium and diluents ratio significantly affected on disintegration and in-vitro dissolution study. Formulation SF9 showed shortest disintegration time (7.3 sec.), shortest wetting time (13.4 sec) and better drug release (99.8%) compared to other formulations. Hence it was selected as optimized formulation. The 3D response surface plots indicated that an increase in the concentration of croscarmellose sodium and an increase in the diluent ratio decreased...
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Posted by admin on Oct 31, 2022 in |
Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self–restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to promote functional recovery in many neurological disorders. Neuroinflammation is a pathological feature of neurodegenerative diseases, which is also indicated to mediate neuronal damage and deteriorate the backward accumulation of Aβ in Alzheimer’s disease. The mechanism for MSC-based therapy in Alzheimer’s disease that MSCs regulate neuroinflammation by microglia activation; this will reduce pathological features such as tau hyperphosphorylation and Aβ deposits and save the spatial learning and memory deficits and their multipotentiality and secretome, based on these findings include cell therapy methods for Parkinson disease mainly focused on the ability of stem cells to differentiate into Dopaminergic neurons producing cells that will replace diseased Dopaminergic neurons. MSC-based...
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Posted by admin on Oct 31, 2022 in |
Presently, in-silico approaches have been introduced as alternative methods for the process of drug invention. The current investigation aimed to explore expectations and the examination of the chemotherapeutic potential dietary phytochemicals as effective anti-cancer agents against HER2. This receptor plays a pivotal role in the development of breast cancer. Here, protein-ligand virtual screening was established as a coherent strategy for the identification of new inhibitors. The primary screening was performed with a molecular approach using iGEM DOCKv2.1 software. Bioinformatics & system analytical techniques were used for the extrapolation of adverse assessments. Lastly, the best compounds with a good outfit score, non-toxic and better drug-likeness esteems were scrutinized for interactions with the key residues and were escalated to final screening. The final re-docking simulation was performed using AD Vina in pyrx 0.8 software. Finally, the top Phytoconstituents as the best binders to the active site of protein structures and muscularly agree with massive experimental consequences. The results confirmed that (2R, 3R)-2-(3, 4-dihydroxyphenyl)-3, 4-dihydro-2H-chromene-3, 5, 7-triol and 2-(3, 4-dihydroxyphenyl)-3, 7-dihydroxychromen-4-one can...
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Posted by admin on Oct 31, 2022 in |
The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotypes, including bioluminescence, biofilm formation, drug resistance, virulence factors expression, and motility. Therefore, the inhibition of QS is considered a new promising target of antimicrobial pathways as anti-virulence compounds that can repress the gene expression of QS. Green tea is one of the most commonly consumed teas in the world. Green tea extract is also a great source of compounds like polyphenols, amino acids, enzymes, pigments, and carbohydrates. Hence, green tea has recently received considerable attention as a new source of safe and effective QS inhibitory substances. In the present study, methanolic and ethanolic various tea extracted were prepared and tested to inhibit quorum sensing mediated bacterial virulence factors such as anti-swarming, and antibiofilm potential...
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