Posted by admin on Oct 31, 2022 in |
Psidium guajava Linn is an herbal remedy used in Ayurveda as a traditional system of medicine in ethnomedicine. It is a tropical evergreen plant that grows in tropical and subtropical climates. It has a wide variety of nutritional components. The whole plant and various parts of the plants possess different types of therapeutic activity, such as Tannin, phenols, triterpenes, flavonoids, essential oils, saponins, carotenoids, lectins and vitamins, dietary fiber, fatty acids, and other active components of guava plants demonstrate pharmacological activity. The fruits and leaves can be freely consumed for their good taste and various nutritional benefits and can be used in various treatments. The most active constituents, like tannins, flavonoids, terpenoids, etc., are mainly found in leaf parts. Guava has a high nutritional value, as it is high in dietary fiber, vitamins C and A, folic acid, dietary minerals, potassium, copper, and manganese. Guava leaves have phenolic compounds which are reported to possess antibacterial, antistress, antigenotoxic, anti-inflammatory, anti-hyperglycemia, anti-rotavirus, cytotoxic, hepatoprotective, etc. In this review, compile all the...
Read More
Posted by admin on Oct 31, 2022 in |
Quercetin (3, 3ʹ, 4ʹ, 5, 7-pentahydroxyl-flavone) is a flavonol, belonging to the class of plant secondary metabolites known as flavonoids. Quercetin and its derivatives have various beneficial effects against ailments like inflammation, oxidative stress, and cancer. The present research work aimed to prepare and characterize quercetin’s solid dispersion (SD) to enhance solubility and thereby dissolution profile and further incorporate it into oral wafers. The solvent evaporation method was used to prepare solid dispersions using the polymer polyethylene glycol 6000 and pluronic F127. The drug and polymers were compatible, as evident from the FTIR data. The optimized batch was further evaluated by FTIR, DSC, PXRD & SEM. Wafers were prepared by solvent casting method using HPMC (5 & 15 cps), PVA, and plasticizer PEG (200,400) and propylene glycol. Quercitin-loaded SD was added to the polymer solution during casting. Highest drug release of 82.96 ± 1.76 % in 240 min was obtained with a drug to carrier ratio (1:1.5). It followed Higuchi’s model when the amount of solvent was 20 ml....
Read More
Posted by admin on Oct 31, 2022 in |
Background: Acute respiratory infections are the most important cause of mortality and morbidity among under-five children in developed and developing countries in the world. There is lack of awareness/ knowledge among parents regarding antibiotic use in children for minor respiratory ailments. Hence, the present study was undertaken. Methods and Methodology: After taking institutional ethical clearance a Descriptive study on 100 mothers of under-five children attending Urban Health Training Centre of KIMS, Bangalore, is enrolled by convenience sampling. Using pre-structured and pre-tested questionnaire proforma, socio-demographic details, a few questions related to acute respiratory infections were collected. After the pre-test, health education was given to the urban health training center participants using flip charts. Followed by 2 weeks of health education, the same questionnaire was given to the subjects, and details were collected. Descriptive statistics and SPSS V20 were used for statistical analysis. Results: Pre and post-test knowledge and attitude were analyzed using wilxcon sign rank test, which showed the effect of health education was found to be statistically significant with...
Read More
Posted by admin on Oct 31, 2022 in |
N. nucifera, often recognized as lotus, is an aquatic plant. Extracts of various solvents have shown therapeutic potential against many diseases. This research focused on screening preliminary qualitative phytochemicals and investigating the seed’s antioxidant activity. Primary and secondary metabolites were discovered in a hydroethanolic fraction of different extracts of lotus seeds. The extractive value, total ash (3.56±0.36) water-soluble (0.86±0.68), and acid insoluble ash value (2.09±0.88) were determined. The solvents benzene, chloroform, ethyl acetate, n-butanol, and aqueous were used as extracts. TPC and TFC content of ethyl acetate extract of seeds were found to be 366.6±10.77 (mg GAE/ g-1 dry weight) and 344.4±3.71 (mg RE/ g-1 dry weight), respectively. The ethyl acetate fraction of the seed extract showed the lowest value determining the highest free radical scavenging activity (105.30 ± 12.06µg/ml) in DPPH and FRAP (142.2± 0.0509 mgAA gm-1). The values were found to be close as compared to the standard (56.40±23.63µg/ml).The results support high antioxidant content in the seed extract of N. nucifera. FTIR and GCMS did the characterization...
Read More
Posted by admin on Oct 31, 2022 in |
Orange (Citrus sinensis), Kinnow (Citrus reticuleta), and Mosambi (Citrus limetta) methanolic, the aqueous extract showed the inhibitory activity on α-amylase and α-glucosidase assay where methanolic, acetone and aqueous extract of these fruit peels exhibited the anti-hypertensive activities. The results showed that the methanol and aqueous extract of Orange, Kinnow, and Mosambi peels inhibited α-amylase and α-glucosidase activities. However, Orange peels (IC50 = 18.4 and 9.43 µg/mL) and Kinnow peels (IC50 = 12.6 and 6.09 µg/mL) exhibited higher capacity to inhibit α-amylase activity compared to Mosambi peels (IC50 = 11.6 and 6.54 µg/mL) and Orange peels (IC50=12.5 and 8.67 µg/mL) methanol and aqueous extract exhibited higher inhibitory effects on α-glucosidase activity compared to Kin now (IC50= 9.78 and 7.65 µg/mL) and Mosambi peel (IC50=4.56 and 10.6 µg/mL).respectively. Similarly, methanol, acetone, and aqueous extract of Orange, Kin now and Mosambi inhibit the angiotensin-1-converting enzyme (ACE) activity. Moreover, methanol and acetone extract of Orange (IC50 =0.38 and 0.40 ug /mL) and Mosambi (IC50 = 0.44 and 0.46ug /mL) showed significant inhibitory capacity...
Read More
