Posted by admin on Sep 30, 2022 in |
Concurrent administration of herbal medicines and conventional drugs is a common practice globally, especially as the patronage of medicinal plants increases across the world. This study aimed to determine the effect of Cryptolepis sanguinolenta administration on the metabolism of chloroquine by evaluating specific Cytochrome P450 isozymes. Reconstituted freeze dried Cryptolepis sanguinolenta was administered to male Sprague-Dawley rats in drinking water for 2 weeks at a dose of 36mg/kg, followed by a single dose of chloroquine (15mg/kg). All the animals were sacrificed by cervical dislocation after 24 h of final drug administration, and the liver was excised for hepatic microsomes preparation. Using the microsomes, the PNPH, AmD and NOD activities were determined as a measure of CYP2E1, CYP2B1 and CYP1A activities, respectively. The study showed that concurrent administration of chloroquine and Cryptolepis sanguinolenta impaired the CYP-mediated metabolism of chloroquine due to competitive inhibition of CYP2B1 by C. sanguinolenta. However, concurrent administration of chloroquine and Cryptolepissanguinolenta showed no significant effect on CYP2E1 and CYP1A. Patients should be advised on the clinical...
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Posted by admin on Sep 30, 2022 in |
The reason for this assessment became the blessing of the use of nanoparticles in lung disease. Nanotechnology has a critical characteristic in inhalation. The dosage shape of pulmonary drug shipping reaches to without delay into a scientific cycle to obtain the impact of the drug. The nanoparticles have a nanosize that achieves the preferred healthy without inflicting infection as compared to standard dosage forms. Various dosage kinds of the pulmonary drug shipping device meet the necessities of this assessment, like metered-dose inhalers, dry powder inhalers, and nebulizers. This drug has a significant impact on the target site. They are used for all kinds of diseases, including asthma, lung cancer, tuberculosis, and various lung diseases. You should easily get a nanometer particle length in the right place. Due to the physiological properties of the lung, the lung is suitable as a target organ for non-invasive short-range and systemic delivery of drug, primarily for non-bioavailable proteins and water-insoluble capsules for conventional drug delivery. Recently, inhaled nanoparticles have been shown to produce...
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Posted by admin on Sep 30, 2022 in |
Introduction: Covid-19 pandemic has posed new challenges to humanity. The definitive cure is yet to be found, while drug repurposing holds the key so far. Remdesivir had been used for the treatment of novel corona-virus. Ivermectin and Doxycycline have also been recommended for treating Covid-19, but their efficacy has not been studied extensively. Methods: We conducted a retrospective study during the second wave of the pandemic. Data were retrieved and 162 patients who had received Remdesivir were divided into 2 groups. Group I (101 patients) received Tab Ivermectin and Cap Doxycycline and Group R (61 patients) received only Remdesivir. The standard treatment was common for both groups. Mortality, duration of intensive care unit stay, and oxygen requirement were compared between the groups. Results: There was no statistically significant difference observed in demography, vaccination status, investigations on admission, comorbidity, and APACHE scoring between both groups. Group R had higher mortality with 75.41% as compared to Group I with a mortality rate of 55.45%, which was statistically significant. The mean duration...
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Posted by admin on Sep 30, 2022 in |
Background: Stress is an important factor determining the mental health of the individual. During this pandemic, a student’s life has had a questionable influence in academics since an online platform was created to educate them. This study was done to assess the stress level among medical and engineering students. Materials and Methods: A cross-sectional study was conducted to assess the stress level. A 15 close-ended questionnaire was validated before circulating among the students through Google forms to various colleges. Statistical analysis was done using SPSS software version 26.0, Descriptive statistics was done to assess the mean and standard deviation and a chi-square test was done to find an association among the students. The P-value <0.05 was considered to be statistically significant. Results: The study was done among the 182 students to assess their stress level. The study results showed that the stress level was found to be almost same among the medical and engineering students, whereas while assessing the online platform to conduct academic classes, it was shown that...
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Posted by admin on Sep 30, 2022 in |
The skin is the human body’s biggest organ, with a surface region of around 2 m2. Generally, the skin was seen as an impermeable boundary. Yet, as of late, it has been progressively perceived that unblemished skin can be utilized as a port for the topical or ceaseless foundational organization of medications. For drugs that have short half-lives, a transdermal course gives a consistent method of organization, to some degree like that given by intravenous implantation. In contrast to intravenous implantation, the passage is non-intrusive, requiring no hospitalization. A method of reasoning to investigate this course exists just for medications exposed to a broad first pass digestion when given orally or those that must be taken a few times each day. That being said, just powerful medications can be directed through this course since there are monetary and restorative motivations not to surpass the fixed estimate past a specific farthest point. Sedate transportation has recently been confronted with two significant challenges. The first is achieving zero request arrival of...
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