Posted by admin on Sep 30, 2022 in |
Substituted quinoxaline has received considerable attention during the last few years as they are endowed with various biological activities and have a wide range of therapeutic properties. Piperazine has proven its worth in numerous clinically active drugs broader areas of therapeutic index. Hence, biologically important quinoxaline derivatives containing a piperazine moiety and Schiff base scaffolds were prepared. The structures of the synthesized compounds were characterised by elemental analysis, IR, NMR, and Mass spectra. All the prepared derivatives were screened for antibacterial and antifungal activity by disc diffusion method using nutrient agar media against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa, & potato dextrose agar medium for activity against Aspergillus niger and Candida albicans using ciprofloxacin as a standard for antibacterial and clotrimazole as a standard for antifungal activity respectively. Fluoro and trimethoxy-containing derivatives have shown promising activity against gram–ve bacteria P. aeruginosa. Some compounds have shown moderate antifungal and antibacterial...
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Posted by admin on Sep 30, 2022 in |
Introduction: Long life, good health, and healthy development are all dependent on proper nutrition. Well-fed children do better in school, develop into healthy adults, and offer their children a better start in life. Undernutrition, on the other hand, remains a major issue, particularly among children who are deprived of adequate food in developing countries. Childhood undernutrition is an underlying cause of an estimated 35% of all deaths among children under five and 21% of total global disability-adjusted life years lost among less than 5 children. Pathological alterations in the body arise as a result of various diseases or excessive indulgence in factors leading to emaciation, resulting in the emergence of undernutrition. In such cases, Deepana–Pachana (appetizer and digestive) Brimhana (Increasing muscle bulk), and Rasayana (Rejuvenizing) therapy is needed. Methods: This review is conducted using a complete and organized search of the available literatures in Ayurveda texts and published articles. The searches were performed using various databases, including PubMed, Scopus, MedLine, Google Scholar, and others. The keywords used for the...
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Posted by admin on Sep 30, 2022 in |
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by Neuroinflammation, oligodendrocyte loss, and axonal pathology. Bergenin, a chief phytochemical constituent of Bergenia species, has been shown to exert anti-inflammatory and antioxidant effects. The cuprizone (CPZ) model is an established mouse model of MS and causes demyelination and induces motor dysfunction, cognitive impairment, and Neuroinflammation leading to damage in the myelinated neuronal region of the brain. Our study examined the potential neuroprotective effects of Bergenin in cuprizone-intoxicated C57BL/6 mice. Mice were fed with chow containing 0.2 % cuprizone for 42 days, followed by Bergenin treatment (25 mg/kg and 50 mg/kg/day, i.p) given for 42 days. At the end of the experimental period, animals were tested on behavioural activities to evaluate changes in balance and motor coordination. Mice were then sacrificed to estimate the biochemical status, and histology of brain sections was used to assess the demyelination rate and myelin inflammatory status. The aim of this study was to examine the neuroprotective effects of Bergenin...
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Posted by admin on Sep 30, 2022 in |
Jasminum multiflorum and Jasminum mesnyi, the ornamental shrubs belonging to family Oleaceae are widely distributed throughout India. Despite their use in the essence industry for making perfumes, oils, and creams, these species are also used in the healing wounds and ulcers, constipation, flatulence, skin diseases, rheumatism, stomatitis, diabetes, stress, antiseptic, diuretics, and gastric disturbance. The present study is designed to establish the authenticity of both species by evaluating various standardization parameters. The stems of both species were collected and dried under shade. Freehand transverse sections were taken for microscopic examination. The standardization parameters such as Moisture content, Ash values, Extractive values, Heavy metal content, Aflatoxin content, Microbial infestation and, Pesticides residue have been determined as per WHO guidelines. Results showed the J. multiflorum stem was greenish-grey in color, cylindrical shaped, fragile and have aromatic odor. Microscopy showed the presence of glandular multicellular trichomes, epidermis, collenchyma, endodermis, medullary rays, vessels, xylem cells, parenchyma, fibre bundle and calcium oxalate crystals. The stem of J. mesnyi is yellowish-green in color the surface is smooth and...
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Posted by admin on Sep 30, 2022 in |
Sandhāna kalpanā (Fermentation process) is a unique procedure implemented in Ayurveda for the preparation of fermented alcoholic and acidic medicinal formulations. Sandhāna dravyās (fermenting agents) act as fermentation initiators in them. The commonly used Sandhāna dravyās are Dhātakipuṣpā (flowers of Woodfordia fruticosa), madhūkapuṣpā (flowers of Madhuka indica) and yeast. Almost in all Sandhāna dravyās, the presence of microflora plays a significant role in fermentation. In recent studies, it was proved that the dried flowers of Dhātaki and Madhūkapuṣpā have yeast colonies in it. Total aerobic microbial count testing of Tulasi puṣpā (Ocimum tenuiflorum – flowers) done in our study also revealed the presence of yeast. Objectives: To determine whether tulasi is having any fermenting activity with respect to the microbial, pharmaceutical and analytical matter. Methods: Total aerobic microbial count testing of fresh and dry flowers of Tulasi and dry flowers of Madhūka was performed. Pharmaceutico-comparative analytical study of 3 samples of Ariṣṭā (a fermented medicinal preparation) named Drākṣāriṣṭā prepared using them was also done. Results: Flowers of Tulasi (fresh...
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