Posted by admin on Aug 31, 2022 in |
The present study aimed to determine the antioxidant potential of different solvent extracts of A. malabarica. Drug discovery from traditional medicinal herbs has played a significant role in the therapeutic management of cancer and, undoubtedly, most novel clinical applications of medicinal plants and its secondary metabolites and derivatives. The leaves extract showed various folklore and traditional applications in India. The polar and non-polar solvents extracts such as hexane chloroform, ethyl acetate, methanol, and aqueous were subjected to various in-vitro antioxidant assays such as DPPH, ABTS, Superoxide, Nitric oxide, Hydroxyl radical and Ferrous ion chelation, Butylated Hydroxy Toluene was used as a standard. The percentage of scavenging and chelation values for antioxidant were obtained and tabulated. Effective concentration (EC50) values are calculated using linear interpolation. The result clearly exhibited that the methanol leaves extract possesses more efficient antioxidant properties than the other extracts. This scavenging free radical capacity can be used as a good anti-oxidizing agent in various fields of medicine, the food industry...
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Posted by admin on Aug 31, 2022 in |
The interaction/incompatibility of drug excipients is a major concern in formulation generation. Compatibility tests for drug excipients constitute an important step of the production of all dosage forms in the preparation stage. The possible physical and chemical interactions of drugs and excipients can influence chemical, physical, therapeutic properties and the dosage form’s stability. The current review involves a fundamental mode of drug degradation, a process of physical, chemical and biopharmaceutical interaction between drugs and excipients. The study of incompatibility is explored in various thermal and nonthermal methods. Once the interaction form is identified, further steps can be taken to enhance drug and dose stability. Current and potential reviews of case studies relating to drug and excipient interactions and their unavoidable incompatibilities have also been studied to deepen greater information about such drug solution scenarios. From the review, we conclude that the subsequent use of the thermal and nonthermal methods provides information for the drug-excipient interaction, which can aid the production of safe dosage forms by selecting an...
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Posted by admin on Aug 31, 2022 in |
Breast cancer continues to pose a serious hazard to women worldwide. (EGFR) was one of the first key targets for these new anticancer drugs to be discovered. Triple-negative breast cancer affects almost half of all women in the World. This study focused on the phytochemicals from a medicinal plant Clitoria ternatea; these medicinal plants possess more phytochemical compounds that effectively fight against cancer cells. The five compounds were selected and a molecular docking study was performed against EGFR protein. The Pharmacokinetics and ADMET properties of these ligands help identify the best hits. Myricetin exhibits the highest binding energy among these five ligand molecules and is the best ligand to inhibit EGFR protein. Hence, this compound may act as a promising agent for treating breast cancer. However, more in-vivo and in-vitro testing is needed to establish their safety and efficacy in this...
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Posted by admin on Aug 31, 2022 in |
Litsea, an outsized genus comprising 400 species of evergreen trees or shrubs, distributed chiefly in tropical and subtropical Asia, Australia, and therefore the Pacific Islands, belongs to the Lauraceae. Litsea polyantha is found throughout North, East, and Central India at an altitude of 1,200 m. It is often planted as an ornamental plant. It is mostly grown as an honest source of fodder for the livestock. It is alittle to medium-sized evergreen tree attaining a height of 21 m and a girth of 1.8m. Barks are dark grey or pale brown colour, exfoliating in quite small polygonal corky scales. In Folklore medicines-Bark, Stem, Roots and Leaves are wont to treat various diseases and disorders. The bark of Litsea polyantha is mildly astringent and used for diarrhea. Powdered bark and roots are used for pains, bruises, contusions and for fractures in animals. Previous chemical investigation of this plant has revealed the presence of beta-sitosterol and actinodaphnine within the bark and an arabinoxylan containing D-xylose and L-arabinose during a molar ratio...
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Posted by admin on Aug 31, 2022 in |
Background: Acute viral hepatitis (AVH) is a major public health problem. There is no specific treatment to attenuate AVH. The potential for adding bile acid in the treatment of AVH is consistently increasing. The objective of this study was to assess the effect of obeticholic acid (OCA) in treating AVH patients and also to compare its efficacy with ursodeoxycholic acid (UDCA). Methods: A prospective comparative observational study carried out at the Department of Gastroenterology of tertiary care hospital. A total of 38 patients were allowed to participate in the study and randomized into two study groups, Group I and II. Each group consists of 19 patients. Patients in group I treated with UDCA. Group II patients treated with OCA. Results: The most common symptoms observed in the two study groups were nausea /vomiting followed by loss of appetite and abdominal pain. Both Group I and II patients showed significant improvement in their symptoms after treatment. The mean of liver function test (LFT) parameters was compared before and after treatment....
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