Posted by admin on Nov 30, 2022 in |
Beginning from simple analytical methods to the recent development of advanced hyphenated techniques stages, various analytical methods have been designed for the multicomponent analysis of drugs. Simultaneous estimation of drugs in the combined dosage form is vital in the pharmaceutical analysis since it is cost-effective and time-saving. Levocetirizine, the R-enantiomer of Cetirizine, is a peripheral H1-receptor antagonist used as a non-sedative antihistamine in treating chronic idiopathic urticaria, angioedema, and allergic rhinitis. Montelukast Sodium is selective cysteinyl leukotriene I receptor inhibitor that acts as an anti-asthmatic agent in the bronchial tubes and lungs. The combination of Levocetirizine with Montelukast Sodium in the pharmaceutical formulation is frequently used in the treatment of Allergic rhinitis as it has been shown to have additional benefits to the patients in reducing the symptoms efficiently. This review article has compared and addressed a variety of analytical methods applied for estimating Levocetirizine and Montelukast Sodium in the combined dosage form. The methods include UV Spectrophotometry methods, High-Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), and...
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Posted by admin on Nov 30, 2022 in |
Nanoparticles are fascinating materials that find many applications in basic and applied research. The chemical reduction technique is one of the easiest methods for synthesizing Nickel Oxide Nanoparticles (NiO NPs) in low-temperature ranges. Nickel Nitrate Hexahydrate (Ni(NO3)2.6H2O), Ascorbic acid, NaOH, and NaBH4 were applied as starting reagents to synthesize NiO NPs. Noble metal oxide nanoparticles have been extensively utilized for many applications in the present scenario. In the present study, attention has been focused on the fabrication of NiO NPs synthesized by the Chemical Reduction Method (CRM). The synthesized nanoparticles were characterized by UV-Vis spectroscopy, FTIR spectroscopy, X-ray diffraction, EDAX, and SEM Techniques. The optical band gap energy value has also been determined as 2.59eV from the UV-Vis spectrum. The nanometal oxide is subjected to photocatalytic activity on Congo red dye under solar irradiation and exhibits very good degrading ability within a few minutes of exposure. Its pharmacological activity is also analyzed using pathogenic organisms like Staphylococcus aureus, Bacillus subtilis, Escheria coli, and Pseudomonas aeruginosa bacteria and found to...
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Posted by admin on Nov 30, 2022 in |
Plants are the natural sources of a vast diversity of molecules, exploited for the benefit of human health. They are the factories synthesizing proteins, carbohydrates, secondary metabolites, and biopolymers. Further, converting these molecules into antioxidants, pharmaceuticals, food, and biofuels is a major industrial process. Plants are becoming significant sources for producing pharmaceutically essential proteins, metabolites, vaccines, industry-based drugs, and bioplastics and are explored for large-scale production. Plant molecular pharming will enable the production of the desired therapeutic proteins. Plant-based pharmaceutical products are advantageous as they are free of vectors and pathogens utilized to transfer genes. Biopharming offers augmented breeding conditions, high biomass productivity, and excellent yield at low cost, making the plants an attractive platform for pharmaceutical production. The ability of plants to produce pharmaceutical-related products and the methodology involved in the production were discussed in this article. Technologies implemented for increased productivity of molecular pharming were also discussed, along with biopharma products, applications and...
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Posted by admin on Nov 30, 2022 in |
Normally, there are two major sexual grievances in men; Erectile dysfunction or impotence and premature ejaculation. Premature ejaculation (PE) is a condition where the orgasm or the emission of semen occurs sooner during sexual intercourse. Erectile dysfunction (ED) is a sexual dysfunction mainly characterized by the inability to either develop an erection or maintain an erection of the penis during sexual intercourse. ED is found to be more prominent in elderly and mature men. As reported in the previously conducted studies, the health-related influences for ED include hypertension, dyslipidemia, diabetes, depression, and heart ailments. As the age increases, the prevalence also increases, especially the age group of 60 to 69 years showed the highest incidences of ED. The median age was of 65 years among all the participants reporting ED. With the increasing tendency in life expectancy in the western countries, and the high prevalence of health ailments like diabetes and various Cardiovascular disorders, the impact on lifestyle and eminence of life imposed by ED in men is likely...
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Posted by admin on Nov 30, 2022 in |
Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the reported ADRs were analysed. Results: 150 suspected ADR reports were collected. Adult patients (14-50 years) experienced 109 (72.66 %) ADRs followed by elderly patients (>50 years) experienced 29 (19.33%) ADRs and paediatric patients (<14 years) experienced 12(8%) ADRs. On the causality scale 62.67% were probable ADRs and on severity scale 63% were moderately severe ADRs. According to MeDRA classification of ADR, Skin and subcutaneous tissue disorders were most common (47.67%), followed by Gastrointestinal disorders (23 %) and Nervous system disorders (13.95%). ADRs were most commonly seen due to antimicrobial drugs (44.3%) followed by Non steroidal anti-inflammatory drugs (NSAIDs) (17.8%). Conclusion: Our study findings showed underreporting in spontaneous ADR reporting system. Continuous efforts through...
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