Posted by admin on May 31, 2022 in |
Computational chemistry is a robust and economical tool for designing and developing potent therapeutic molecules. Benzimidazole and its analogues are compounds with a unique pharmacophore that derives its application as broad-spectrum antimicrobial agents. A quantitative structure-activity relationship (QSAR) study was performed using a data set of 28 benzimidazole analogues with antimicrobial activity. Descriptors were generated using various free software’s such as PaDEL-Descriptor, SwissADME and OCHEM (Online chemical modelling environment). The statistical analysis was performed using the Stats. Blue software by multiple linear regression (MLR) method for determining the relationship between dependant variable and various independent variables. The best QSAR model had an r2 value of 0.6773, and the predictive r2 value for external validation was 0.7150. The results show that a positive correlation is established between the descriptors, TPSA (Topological polar surface area), H-bond acceptors, iLOGP (Implicit LOGP), GGI4 (Galvez topological charge indices of order 4), thereby achieving the most accurate...
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Posted by admin on May 31, 2022 in |
Phyllanthus niruri commonly known as Keezhanelli is traditionally used as a medicinal plant in many parts of the world. In this study, phytochemical screening was the hepatoprotective potential of the plant investigated. Two plant forms, namely, dry powder and fresh leaves were used. Aqueous and methanolic extracts were prepared from both forms, and the experiments were carried out. The hepatoprotective potential of the Phyllanthus niruri extracts was evaluated by checking the enzyme activity in CCl4 toxicity-induced chicken liver. The liver was subjected to different extracts and the SGPT, LDH levels were calculated. The methanolic extracts displayed higher SGPT levels in the liver after CCl4 treatment (~121 IU/L) while the dry powder aqueous extracts were the lowest (79.5 IU/L). The LDH levels were the highest for fresh leaves methanolic extracts (323.23 IU/L) while the dry powder aqueous extracts (303.01 IU/L) had the lowest level among all extracts. Thus the fresh leaves methanolic extract was proven to be the most efficient out of all of the Phyllanthus niruri extracts. All of...
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Posted by admin on May 31, 2022 in |
The concept of Quality by Design reflects current global regulatory thinking related to pharmaceutical products. The pharmaceutical industry needs to improve its performance. Newer technologies need to be implemented that can effectively reduce the cost and, at the same time, improves product quality. Quality by design (QbD) is the best solution to build quality in all pharmaceutical products. The main objective of QbD is to ensure the quality product resulting from a combination of prior knowledge and new estimation during development. QbD is being widely promoted by the food and drug administration (FDA) and the international conference on Harmony (ICH). Quality by design (QbD) in the pharmacy field is mainly based on the understanding of how materials and process parameters affect the quality profile of final products. In this article, the key elements of QbD viz., Target product quality profile, Critical quality attributes, Risk assessment, Design space, and Control strategy are discussed to understand the performance of dosage forms within the design space. Tools of QbD (DoE, Quality risk...
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Posted by admin on May 31, 2022 in |
Oroxylum indicum (O. indicum), commonly known as the Indian trumpet tree, belonging to the family Bignoniaceae, is a medicinally important, small, or medium-sized plant used to treat various diseases and also has its importance in the traditional system of medicine. Various parts of the plant have been proved to possess useful pharmacological activities. It is native to the Indian subcontinent, extending to Sri Lanka, China, and Malaysia. A variety of experimental studies has been performed both in-vitro and in-vivo to determine the various uses of the plant. Also, various important chemical constituents have been isolated, which act as a source of medicinally important compounds. Flavonoids, the most abundant and important constituents, are found in almost all parts of the plant. Several studies have been performed to reveal information on O. indicum. The aim of writing this review is to compile information from published materials on various aspects of the...
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Posted by admin on May 31, 2022 in |
During the past few years, diabetes has been one of the leading metabolic disorders. It occurs when the body does not produce enough insulin or the body cells are not efficient enough to take up the insulin. This increases blood glucose levels that affect the body system, particularly blood vessels and nerves. Due to the side effects of allopathic medicines, individuals are searching the other alternatives with lesser side effects and more efficacy. Such properties are present in plant-based product. Picrorhiza kurroa Royle ex. Benth. belonging to the family Plantaginaceae/Scrophulariaceae distributed in Himalayan regions of China, Pakistan, India, Bhutan and Nepal. The tribes of North–Eastern Himalayan regions of India use this herb as for controlling diabetes. The present study was conducted to evaluate the antidiabetic activity of ethanolic extract of P. kurroa in-vitro and in-vivo. In-vitro antidiabetic activity was done by inhibiting the alpha-amylase enzyme, which is hydrolyzing enzyme for the starch by plant extract. In-vivo antidiabetic activity was done by injecting alloxan monohydrate (120 mg/kg bw) to male...
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