Posted by admin on May 31, 2022 in |
Acute Lung Injury (ALI) and its more severe form Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome with a high mortality rate (27-41%). There is no pharmacological therapy for ALI treatment so far because of the complex mechanism and involvement of multiple pathways. So, the present study was designed to test the role of different extract/fractions of fruits of a traditional plant Randia dumetorum Lamk. utilizing a mouse model of acid aspiration (HCl) mediated ALI. Hydromethanolic extract (HME) was screened for anti-inflammatory activity at 100, 200, and 400mg/kg doses employing total and differential cell count in bronchoalveolar lavage fluid. Our data demonstrated that oral administration of HME in mice before induction of ALI resulted in reducing the number of BALF inflammatory cells, particularly neutrophils, in a dose-dependent manner. Further, HME was partitioned into ethyl acetate soluble (EASF) and ethyl acetate insoluble fraction (EAISF) to extract phytoconstituents based on differential polarity. Our data revealed that EAISF showed better efficacy than EASF for the amelioration of lung inflammation. Similarly, bioactive...
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Posted by admin on May 31, 2022 in |
Background: To date, the 2019 novel coronavirus pneumonia (COVID-19) is the greatest public medical issue in the world. World Health Organization (WHO) declared this outbreak a “public health emergency of international concern” on January 31, 2020. Therefore, it bodes well to look for a potential biomarker that could quickly and effectively distinguish serious cases early. Of the total confirmed Covid-19 patients, the severe cases often suffer from underlying diseases such as cardiovascular disease and diabetes that can accelerate the movement of 2019 novel coronavirus (SARS-CoV-2) infection. Moreover, acute respiratory distress syndrome could lead to death in some severe Covid-19 patients, and various disorders often accompany this. Biochemical findings showed representative features of acute respiratory distress syndrome and association of multiple organs. Aim: To estimate routine biochemical parameters of patients admitted to the Covid-19 ward. Method: Clinical samples from cases of Covid-19 admitted to Adesh Medical College and Hospital, Mohri, Shahbad (M), Haryana, India, during 1st, 2nd, and 3rd waves were collected and analyzed. Result: In this study, we investigated...
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Posted by admin on May 31, 2022 in |
Hedychium spicatum is one of the plant species reported from the northern Himalayan ranges of India, belonging to the family Zingiberaceae, with ethnobotanical values and is well-known for their ethnomedicinal applications. In the present investigation, pet ether and ethanolic rhizome extracts of Hedychium spicatum were Analyzed by gas chromatography-mass spectrometry (GC–MS) to identify the important phytochemical constituents. The GC–MS analysis of pet ether and ethanolic extracts from rhizomes of Hedychium spicatum detected the presence of numerous phytochemical compounds. Further, the literature review reported rhizome extracts of H. spicatum to have remarkable anti-inflammatory, antioxidant, cardioprotective, and antibacterial activities. The results of DPPH and ferric reducing antioxidant power assay recorded maximum antioxidant activity in Hedychium spicatum ethanolic rhizome extract at 500mg/kg dosage. As well as the ethanolic extract exhibited maximum α-amylase inhibition activity followed by exhibiting aldose reductase inhibition. Subsequently, the six identified compounds were analyzed for their bioactivity through in-silico molecular docking studies. Results revealed that 7-hydroxyhedychenone might have maximum antioxidant and antidiabetic properties among the phytochemical compounds identified, followed...
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Posted by admin on May 31, 2022 in |
The various medicinal plants have been used in the Ayurvedic medicine system to treat various diseases for a long period. The plant shows first-line defense mechanisms by secondary metabolites against different diseases and foreign particles to build immunity. This metabolite are classified as phyto & polyphenolic compound. Antioxidants play an important role in humans due to the presence of this polyphenolic compound and other phyto-compound. Either body metabolism generates free radical as an endogenous source or different pollution, food intake as an exogenous source. Cellular damage is happened by the excessive production of free radicals. Antioxidants arrest the free radicals by reducing their activity. There are nine medicinal plants such as Leucas cephalotes Spreng (Dronapushpi), Andrographis paniculata Nees (Kalmegh), Piper longum (Pippali), Desmodium gangeticum DC (Shalmali), Plumbago indica Linn (Raktachitrak), Zingiber officinale Rosc (Adrak), Calotropis procera R.Br. (Arka), Sesbania sesban Merrill (Jayanti), Hemidesmus indicus R. Br (sariva)] selected on the basis of their Ayurvedic property. Phytochemical analysis, Total phenolic content (TPC), total flavonoid Content (TFC) and antioxidant tests via...
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Posted by admin on May 31, 2022 in |
Parkinson’s disease (PD), identified as the second most common neurodegenerative disorder, is a progressive disease that impairs the ability to control voluntary movements mainly. According to the findings of the pathogenesis of PD, lesions in dopaminergic innervation of the basal ganglia cause degeneration of neurons in the substantia nigra and thus leads to loss of striatal dopamine level. Hence, enhancement of dopaminergic transmission restores partial motor functions. In the current review, the possible in-vivo animal models have been described in detail, which mostly resembles the Parkinsonian state in humans and has helped research involving pathogenesis, treatment, and evaluating drugs having Anti-Parkinson activity. This study aims to set down all the possible models to screen agents that have a therapeutic or symptomatic role in treating Parkinson’s disease. Every model has its advantage and disadvantage, which must be carefully considered when choosing the model to be...
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