Posted by admin on Mar 31, 2022 in |
A chronic illness that affects a person’s mood, thoughts, physical health, and behavior patterns is considered depression. Currently used anti-depressant drugs such as selective serotonin reuptake inhibitors (SSRI) and tricyclic anti-depressants (TCA) are showing various side effects and thus, the search for a new anti-depressant herb without side effects is important. The intend of the present study was to evaluate the anti-depressant effect of methanol, chloroform and aqueous extract Acacia nilotica leaves at doses of 200 mg/kg in experimental animals. In-vivo screening models like Forced Swim Test (FST), Tail Suspension Test (TST) and Spontaneous Locomotor activity (SLMA) were used to assess the anti-depressant effects of the methanol, chloroform, and aqueous extracts of Acacia nilotica Linn. The dried-up leaves were subjected for shade drying and size reduced to powder and extracted by soxhlet apparatus. The extracts were subjected to phytochemical tests and the carbohydrate, tannins, alkaloids, flavonoids, saponins, glycosides and steroids were found to be present. Imipramine (30 mg/kg, i.p) was used as the reference standard, and it showed significant...
Read More
Posted by admin on Mar 31, 2022 in |
The present study focused on the formulation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in treating actinic keratosis. The in-vitro release profile of solid lipid nanoparticle gel is higher than the marketed cream formulation; thus, we can reduce the dose of formulation by this method. This is prepared using tween 80, tween 20, glycerol monostearate, glycerol, and lecithin. Pre-formulation studies for the pure drug were conducted, and formulations were evaluated based on viscosity, encapsulation efficiency and in-vitro drug release study using franz diffusion cell. FTIR study of pure drug-polymer and formulation proves there is no chemical interaction between them. Formulation SLN2 had appropriate viscosity of 1738.34, the highest encapsulation efficiency of 94.45%, drug loading 31.97%. SLN2 shows 95% cell viability. The in-vitro release study was found to have a zero-order release profile. Compared to all other formulations, this indicates the predominant mechanism of drug release is...
Read More
Posted by admin on Mar 31, 2022 in |
Introduction: Most human oro-facial infections originate from odontogenic infections, and prescribing antimicrobial has become a ubiquitous phenomenon. The World Health Organization (WHO) has recognized the inappropriate, indiscriminate and irrational use of antimicrobials leading to antimicrobial resistance. Aim & Objective: To assess the knowledge of antimicrobial resistance and antimicrobial prescription among dental practitioners in Chennai city. Materials and Methods: A total of 110 registered dental practitioners participated in this cross-sectional study. A pre-validated and self-administered questionnaire was prepared and distributed to the registered dental practitioners in Chennai city to collect the demographic details and the information regarding knowledge and practice towards antimicrobial resistance and an antimicrobial prescription for the most common oral conditions and commonly prescribed antimicrobials for their patients were obtained. Statistical analysis. The data were statistically analyzed by using the Statistical Package for the Social Science version 20.0. Descriptive statistics were performed, and a Chi-square test was done to assess the association between knowledge and practice of BDS and MDS participants. Results: 79.66% of BDS and 92.16% of...
Read More
Posted by admin on Mar 31, 2022 in |
Biosorption is a cure to atmosphere containing heavy metals and also an alternative to physical and chemical methods used for heavy metal removal. The main aim of this review is to highlight the various mechanisms of biosorption by using various biosorbent viz. microorganisms, no-living biomass, herbal plants for the removal of heavy metals. Industrialization, globalization has provided an ease to humans, but every comfort has its own disadvantages, in this case, it will increase heavy metal pollution which threatens the life of human, animals, and plants. Bio sorption used bio sorbent to remove heavy metal or sorbate and is economical. Nowadays, the natural biological material is used to remove heavy metals like vegetable waste and fruit peels. Herbal medicinal plants are also used to remove heavy...
Read More
Posted by admin on Mar 31, 2022 in |
Costus igneus, commonly known as insulin plant, has been traditionally reported for its anti-diabetic, anti-oxidant, anti-inflammatory, anti-proliferative, anti-urolithiasis, hypolipidemic, neuroprotective and anti-microbial activity. This review is all about anatomical and morphological investigations of Costus igneus, including its medicinal use. Secondary metabolites of this plant such as b-sitostirol, corosolic acid, diosgenin, quercetin, catechine, oleic acid show mainly anti-diabetic activity. At present finding, Costus igneus have characteristic morphological, anatomical, and proximate features that could be used to differentiate it from other members of the Costaceae family. This review article collected information using the following searching engines such as Pub Med, Science Direct and Google Scholar, etc., and mainly focused on English written documents. The present review article attempts to explore various medicinal properties of Costus igneus (insulin plant) and mode of action of all major phytoconstituents as anti-diabetic activity for advanced research purposes and its suitable formulations development in the future for the welfare of...
Read More
