Posted by admin on Mar 31, 2022 in |
Pullulanase (Pullulanase-α-glucanohydrolase EC 3.2.1.41) is a glucanohydrolase enzyme that can break down the pullulan and allied oligosaccharides into glucose. Promising of starch-based industries are biofuels, starch syrup, nutraceuticals, etc., increase the glucanohydrolases demand. Present investigation revealing that the Bacillus cereus KKSJ 1981 is enhanced the production of pullulanase through the optimization of temperature, agitation speed, pH, soluble starch concentration, MnSO4 and yeast extract. Response surface methodology (RSM) was utilized to optimize the selected six parameters. A central composite design with 50 experiments was performed in this investigation. The analyzed data depicts that the correlation coefficient (R2) value was 0.9873, and the adjusted R2 value was 0.9717 indicates the high significance of the model. Further, the selected parameters in optimum conditions were predicted through the developed mathematical model, and validation experiments were performed at these conditions. Overall, 1.2 folds of pullulanase were improved through the RSM based...
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Posted by admin on Mar 31, 2022 in |
The research work is focused on the formulation of dermal drug delivery system of Fisetin. The formulation based on the principal to causes deeper skin penetration and minimal systemic delivery for the management of skin cancer by enhancing the dermal bioavailability of formulation with reducing dosage requirement in sustained delivery mode by direct targeting of formulations to the skin. Two formulations viz transethosome and ethsosme were formulated to attain the efficient dermal delivery of fisetin. The surface morphology was studied by using Zeta sizer procedures. The formulation had shown adequate strength, consistency, cohesiveness, and list of thickness as 330.50 g, 314.69 g, 2.34.50 g, and 112.71 g separately. The streamlined fisetin transethosome gel definition detailing had 90% spreadability and a pH of 6.5 ± 0.2. These properties guarantee uniform spreading of OFTF-gel at the application site without causing skin irritancy. OFTF-gel had shown great substance consistency with 99.5 ±1.5 % of medication recuperation from the gel by HPLC assessment. The skin treated with transethosomes gel had shown altogether higher...
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Posted by admin on Mar 31, 2022 in |
In the present study, the aqueous and ethanolic extracts of Vitis vinifera seeds were studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The plant extracts were also examined for their antioxidant activities by using the free radical 1, 1-diphenyl-2-picryl hydrozyl (DPPH) scavenging method under in-vitro. The study revealed that the different concentrations of the extract possessed a very good amount of result and exhibited potent radical scavenging activity using DPPH SA substrate. The aqueous (68.5%) and ethanolic extract (74.2%) of Vitis vinifera seeds showed a significant inhibitory effect on alpha-amylase activity ethanol extract (74.2%), aqueous extract (68.5%). In the alpha-glucosidase activity ethanolic extract (75.7%) and aqueous extract (74.5%) showed a significant inhibitory effect when compared with standard acarbose drugs. Therefore, it is suggested that the aqueous and ethanolic extract of Vitis vinifera seeds could be used as a potential source for natural anti-diabetic and antioxidant compounds and could have the potential use in the management of diabetes mellitus and...
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Posted by admin on Mar 31, 2022 in |
Natural molecules from plants are vital sources to explore potent lead molecules in the drug discovery process. Plants as A source of medicine is an ancient practice in India. The Indian subcontinent is a wide repository of medicinal plants that are being used in the traditional system of medicines. Kalanchoe is one of the medicinal plants; the succulent leaf juice is prepared by grinding the leaves mechanically and is a Tyler-made medicine being prescribed by traditional practitioners to combat various diseases and disorders. Various species of Kalanchoe find an important place in traditional medicine across the globe. This review article is a systematic compilation of recent updates on the worldwide ethnopharmacological uses and phytomolecules as therapeutic markers, pharmacological profiles, pharmacokinetic studies and SAR of bufadienolides from varied species of Kalanchoe. The systematic compilation of review articles will direct the scientific community to focus their research by doing further molecular and targeted throughput screening of the lead molecules from Kalanchoe, results in drug discovery from the potent herbal plant Kalanchoe....
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Posted by admin on Mar 31, 2022 in |
Tea brewed from the plant Camellia sinensis is the second most popular beverage consumed worldwide after water. The first two leaves and the leaf bud are mainly used for commercial tea production, and depending on the variation of processing techniques, it is primarily categorized into -white tea, green tea, oolong tea, and black tea. Different varieties of tea are known for their contribution in little to a large amount of bioactivity or sensory attributes due to variation in the chemical constituents, thus providing health benefits. Throughout the years green tea has been extensively investigated by researchers for its health benefits; however, black tea is now emerging as more beneficial to health and catching serious attention by researchers. Apart from the methylxanthines, amino acids, phenolics, and catechins, the two major components, i.e., the TFs and TRs are solely responsible for black tea’s characteristic color and taste and are proven to have health benefits. This review aims to provide available information on Theaflavins (TFs), their bioactivity, and, most importantly, the various...
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