Posted by admin on Mar 31, 2022 in |
Copper is an essential trace element involved in a plethora of functions being a component of several enzymes. Copper deficiency affects people of all age groups, including infants, children, pregnant women, and men. Deficiency occurs due to numerous factors hindering the absorption/uptake of copper. Male Wistar rats (35-50 gm) were divided into four groups: Group 1: Negative control – fed with standard feed (Ashirwad Industries, Chandigarh) and tap water was provided ad libitum .Group 2: Copper control group- Fed with diet containing 126 nmol Cu/gm. Tap water was provided ad libitum. (c) Group 3: Pair-fed group – Fed with 126 nmol Cu /gm diet but the amount of feed given was equal to the feed consumed by the copper-deficient group the previous day to account for stress and starvation effect caused due to low intake diet. Tap water was provided ad libitum (d) Group 4: Copper deficient- animals were fed with 6.3 nmol Cu / gm diet, and demineralized water was provided ad libitum. The experiment was conducted for...
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Posted by admin on Mar 31, 2022 in |
Ondansetron hydrochloride (ONH) is an exceptionally harsh, powerful antiemetic drug utilized for the treatment and prophylaxis of chemotherapy or radiotherapy or postoperative prompted emesis. This investigation aims to detail and assesses taste-covered quick-dissolving tablets (FDTs) of ONH to expand patient consistence. ONH taste veiled granules were set up by a strong scattering procedure. Dissolvable dissipation techniques were utilized for such readiness. Totally taste veiling with zero arrival of medication in phosphate support pH 6.8 was acquired from granules arranged by dissolvable vanishing strategy utilizing drug: polymer proportion of 1:2, from which four equations pass a pre-pressure assessment and compacted to FDTs and assessed for their medication content, in-vitro breaking downtime, in-vivo deterioration time, wetting time and in-vitro drug discharge profile. It was tracked down that the tablet definitions F8 with cross carmellose sodium as super disintegrant showed the fast medication discharge when contrasted with unadulterated medication. T50 and DE 30% for the definition F8 was discovered to be in 7 min and 73.5%, Hence reasonable as quick-dissolving...
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Posted by admin on Mar 31, 2022 in |
Rheumatoid arthritis (RA) is a general inflammatory disorder touching about 1.3% of the grown-up census of the world. Over the last two decades, a significant development has been done in the thoughtfulness of RA pathophysiology, best outcomes, and successful treatment strategy, and the credit of the significance of diagnostic agents and treating RA near the beginning. Earlier than novel treatments were obtained, RA caused notable incapability and deaths. At present, it is customary that principal diagnostic agents and therapy are significant and helpful. Development in the treatment of RA made it likely to manipulate signs in inflammatory arthritis. The early hour diagnosis and treatment of RA can prevent or reduce the progression of joint erosion to about 90% of patients; by this means irreversible disability can be prevented. In advance and more effective treatment significantly improves the prognosis of RA. The advancement of novel instruments to assess disease activity and recognize remission has brought about innovative treatment strategies to inhibit RA ahead of joint damage forever. The pharmacological therapy...
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Posted by admin on Mar 31, 2022 in |
The majority of current drug delivery systems are existed as water-insoluble drug delivery systems but rarely water-soluble drug delivery systems. Low aqueous solubility is a common problem in pharmaceutical development. About 40% of commercialized drugs and as many as 90% of drugs in the discovery are low aqueous soluble. When given through traditional dosage forms, such drugs fail to be soluble and have limited bioavailability, so they tend to show limited therapeutic effect and often fail. Various methods to solubilize drugs usually involve a combination of pH modifiers, salt forms, co-solvent systems, surfactants, or complexation. A complex drug system is generally a complex system incorporated with API and compatible excipients to produce the desired effect. Complex drug systems are simply referred to as uncommon products that were not typical tablets. However, with the rise of insoluble API biologics, complex drug systems are quickly gaining importance. Most used complexes include phosphor lipid complex, chitosan complex, cyclodextrins complex, phosphatidylcholine complex. Complex drug systems are employed in various areas for treating various...
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Posted by admin on Mar 31, 2022 in |
Alzheimer’s is a degenerative brain disease associated with memory depletion and mild cognitive dysfunction, leading to dementia. Today’s world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD. Medicinal plants play a major role in Alzheimer’s and memory loss control. Ayurveda, homeopathy, Siddha & Unani medicine systems are the main conventional therapeutic approaches. In animal studies, AD caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. The anticholinergic drug Scopolamine induces amnesia in rodents. In the present study, the efficacy of an Extract of Hylocereus undatus (HUFE) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at a dose of 2.5 mg/kg, HUFE was given in rat at a dose of 100 mg/kg body weight, 200 mg/kg body weight, and 300 mg/kg body weight. The anti-Alzheimer activity was assessed by Morris water maze, novel object recognition test, and Y-maze. And...
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