Posted by admin on Mar 31, 2022 in |
In this present work, BCS class II Candesartan celexitil, as an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure, was successfully loaded in the solid lipid nanoparticles (SLNs) by using hot high-speed homogenization method. The SLN formulations were prepared and optimized by Box Benhken design study. The SLN was characterized by Nanophox size analyzer and Delsa nano C zetameter. The SLN was also evaluated for particle size, zeta potential, entrapment efficiency, drug loading, surface morphology, and in-vitro dissolution study. The average particle size, zeta potential, percentage entrapment efficiency, and drug loading were found to be 177nm, -8.23 mV, 95.72 %, and 8.23 %, respectively. The dissolution study of SLN showed 92.07 % released in six hours compared to 46.89% release from the pure drug, which indicates a significant improvement in the bioavailability. The release of the drug from SLN showed zero-order kinetics. The stability study was also carried out and found to be stable after three...
Read More
Posted by admin on Mar 31, 2022 in |
Objectives: To assess the risk factors, opportunistic infections (OI’s), prescribing patterns along with ADRs, medication adherence, and quality of life (QoL) among HIV patients. Methods: This is an Ambi-directional cohort study conducted at the Government hospital, Bhimavaram, for 6 months from July 2019 to December 2019, including 201 HIV patients’ data. The data were analyzed using GraphPad Prism 8.3.0. Descriptive statistics & paired t-test were employed to assess risk factors, OIs, prescribing patterns, and QoL, respectively. Results: Out of 201 patients. Heterosexuality (96%) was found to be a predominant risk factor in this study. Between type-1 and type 2 HIV patients, Tenofovir Disoproxil Fumarate/ Lamivudine & Efavirenz (TLE) and Tenofovir Disoproxil Fumarate/ Lamivudine/ Lopinavir/ Ritonavir (TL/ATV/r) were the first-line and second-line therapies respectively in type-1 patients; however, TL/LPV/r was reserved for type 2 individuals. Among 201 patients, 55 patients were reported with 60 ADR’s and the predominant ADR was found to be rashes (36%). Approximately 76% were reported with a history of OI’s, the most prevalent being TB (39%)....
Read More
Posted by admin on Mar 31, 2022 in |
The presentation of this work aims to update professionals on issues associated with selecting the film former in the film coating process. Film coating finds applicability in a diverse field that may be for conventional (immediate) release and modified-release intended for enteric/ delayed-release or barrier membrane controlled release (extended-release). In the pharmaceutical field, film coating of the substrate is achieved by spraying the coating material in liquid medium onto them. The formulation of coating material is a solution or dispersion of film-forming polymers and excipients in aqueous or organic solvents. Film formers are the chief amongst the component of coating formulation that delineates the functional properties of the film-coated pharmaceutical along with other factors like additives, process, equipment, technology and many others. Polymers used as film former are available in different grades, determined by their molecular weight and viscosity. Their glass transition temperature (Tg), along with the grade of polymer, influences the film coating process along with the functional properties of the film coat. Summarised information on the technical...
Read More
Posted by admin on Mar 31, 2022 in |
Ziziphus rugosea member of Rhamnaceae family, is found in the deciduous and semi-evergreen forests of Western Ghats, India. It is commonly known as suran in Hindi. chunukoli in Urdu, badara in Sanskrit, and toran in Marathi. Z. rugosa is traditionally used in the treatment of skin diseases, mouth ulcers, dropsy, boils, diarrhea, tachycardia, syphilis, miscarriage, misconception, flatulence, hysteria, And as astringent. It has been investigated foranti-diabetic, anti-inflammatory, α-glucosidase inhibitory, cytotoxic, antioxidant, antibacterial, anthelmintic, analgesic, and insecticidal activities. It is reported to contain diverse classes of secondary metabolites like alkaloids, flavonoids, glycosides, saponins, triterpenoids, tannins and phenolics. Several constituents are reported from different parts of this plant cyclopeptide alkaloids (rugosanin-A, amphibine-D, rugosanin-B, sativanin-H, nummularine-P), pentacyclic triterpenoids (2-α-hydroxyursolic acid, oleanalic acid, alphitolic acid, betulinaldehyde, betulin, betulinic acid, lupeol), flavonoids (kaempferol, quercetin, myricetin, apigenin, apigenin-7-o-glucoside, kaempferol-4-methylether, kaempferol-3-o-rhamnoside, luteolin, luteolin -7-o-glucoside), dihydroxy benzoic acid (vanilic acid), quinoline (isoquinoline). The present review is an attempt to connect the traditional use of Z. rugosa to its phytochemistry and pharmacology, thereby opening up new avenues in...
Read More
Posted by admin on Mar 31, 2022 in |
Electrospinning is the fiber-forming process using an electric field where electrostatic forces are employed. By this process, continuous nanofibers range from 0.01 to 10 micrometers can be obtained. Nanofibers produced by the electrospinning technique has application in various fields such as tissue engineering, wound dressing, filtration, protective clothing, drug delivery, and sensor applications. This study aimed to develop a novel bio medicated nanofibrous scaffold for wound dressing applications. Nanofiber of polyvinyl alcohol and sodium alginate loaded with silver sulphadiazine were successfully prepared by the electrospinning method. The formulations were subjected to various physicochemical evaluations such as weight variation, surface pH, folding endurance, moisture evaluation studies, biodegradability, and in vitro drug release studies. All the prepared nanofibers were found to be transparent, flexible with a smooth surface. The physicochemical characteristics of Medicated nanofibers were satisfactory concerning weight variation, surface pH, folding endurance, moisture loss, and moisture uptake studies. The drug entrapment was in the acceptable range for all the formulations, indicating a uniform distribution of the drug. Nanofibers prepared using...
Read More
