Posted by admin on Mar 31, 2022 in |
Background: In Ayurvedic literature, Aloe vera, turmeric, honey, karanj oil, and cow ghee are documented for medicinal properties like anti-infective, anti-inflammatory, anti-oxidant, anti-coagulant and wound recovery. Objective: In this study, we aimed to evaluate the efficacy of a topical gel containing Aloe vera extract, turmeric, honey, karanj oil, and cow ghee for wound healing. Methods: Topical gel was prepared and evaluated for skin irritation and efficacy. Skin irritation studies were performed on rabbits according to OECD guidelines 402. Wound healing activity was performed on Wistar rats in the excision wound model, incision wound model, and burn injury model. Results: Treatment with formulation significantly ameliorated wounds compared to the vehicle control group in each wound injury model. Efficacy was comparable to the standard which was confirmed by amelioration of wound contraction, increase in tensile strength, attenuation of inflammatory cytokines TNF-α, IL-6, IL-10 and histological studies. Skin irritation studies on rabbits showed that formulation is non-irritant. Conclusion: In the topical gel used in this experiment showed enhanced wound healing properties in...
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Posted by admin on Mar 31, 2022 in |
The objective of the study was to investigate the in-vitro anti-cancer effect of Panchagavya on the Human Colon Adencarcinoma (HCT-116) cell line. Panchayavya was formulated using five products from Cows, namely; Cow dung, Cow urine, Cow milk, Cow curd and Cow ghee. The whole mixture was further freeze-dried and stored until further assay conduction. The growth inhibitory activity of the raw Panchagavya (PGS1) and formulated Panchagavya (PGS2) in HCT-116 colon cancer cells were investigated by 3-(4, 5 – dimethyl thiazolyl – 2) – 2, 5-diphenyl-tetrazolium bromide (MTT) assay. The results from MTT assay indicated that cell proliferation was significantly (p <0.05) inhibited in a concentration-dependent fashion, especially by formulated Panchagavya. Thus, Panchagavya formulation has a potential anti-cancer activity. In this context, we investigated the anti-proliferative potential of Fresh Panchgavya preparation against the Human Colon Adenocarcinoma (HCT-116) Cell Line. To the best of our knowledge, this is the first report demonstrating in-vitro anti-proliferative efficacy of Panchgavyaagainst Human Colon Adenocarcinoma (HCT-116) Cell...
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Posted by admin on Mar 31, 2022 in |
Alzheimer’s disease is the most frequent cause of dementia worldwide and its incidence is increasing due to the world’s aging population. Alzheimer’s disease (AD) is one of the greatest medical care challenges of our century and is the main cause of dementia and neurodegenerative diseases. Dementia is defined as an acquired loss of cognition in many cognitive domains. Herbal medicine has evolved as the greatest option for the treatment of Alzheimer’s disease due to its wide availability, low cost, high patient compliance, ease of formulation and lack of harmful side effects. Novel techniques can be used for the development of herbal medicine. In these research article animal studies, has been carried out to known Alzheimer disease (AD) caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. In the present study, the efficacy of an ethanolic extract of Cissus quadrangularis stems (EECQ) was evaluated against scopolamine-induced Alzheimer’s in the Wistar albino rat. As Cissus quadrangularis stems contain many active chemical constituents, including...
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Posted by admin on Mar 31, 2022 in |
The adverse environmental impact of fungicides used in plant disease control is escalating day by day. Generally, plant diseases are controlled by synthetic fungicides, chemical methods, and bio-control agents. Chemical methods lead to deterioration of soil fertility and cause pollution. Being highly stable and resistant to biodegradation, chemical fungicides also enter the food chain and are responsible for many harmful effects on human health and the environment. Hence, eco-friendly alternative methods are of great urgency. One of the prominent approaches in this direction includes utilizing plant extracts with natural antifungal constituents. So, a study was attempted to determine the antifungal and phytochemical activity of underexploited leafy vegetables. Methanol and water extracts of the leaves were tested against two economically important plant pathogens Alternaria solani and Pythium aphanidermatum and the antifungal activity of plant extracts was determined. All the plant species under study showed inhibitory activity against the plant pathogens. However, B. diffusa and C. frutescens exhibited maximized efficiencies. Moreover, the water extracts of B. diffusa and C. frutescens (1%)...
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Posted by admin on Mar 31, 2022 in |
In recent times, the use of radiopharmaceuticals in Medical Imaging and Nuclear medicine has increased. They are a special group of pharmaceuticals with short-shelf life in their final state, and their preparation has been done with utmost care. Due to the inherently hazardous nature of radionuclides on the one hand and the associated concern about radiation safety for patients and staff handling them on the other, this necessitates extreme caution during their manufacture, dispensing, storage and disposal. Therefore there is a need for the implementation of the regulatory guidelines to improvise the quality, safety, and potency of radiopharmaceuticals. This review mainly highlighted the regulatory framework for handling, disposal, and clinical trials of radiopharmaceuticals according to India, Europe Union and USA guidelines. However, in India Cosmetic and Drug act 1940 and rules govern the pharmaceutical industries for the regulatory framework and in Europe and the USA, they follow the EANM and USFDA guidelines. This guideline helps to improvise and remove the barrier for submission to regulatory authorities. The review article...
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