Posted by admin on Mar 31, 2022 in |
The present investigation screening and characterization of α-amylase and antimicrobial compound producing filamentous fungi is used for extensive commercial applications in various sectors and is highly demanded in the Biotech industry. The results reveal that out of the carbon substrates alone, sugarcane bagasse with a combination of Tween-80 was found to yield maximum α-amylase (151.76 IU) under solid-state fermentation by different species of fungal species such as KRV_001Chaetomium oryzae, KRV_002 Penicillium citrinum, KRV_003 Aspergillus flavus, KRV_004 Penicillium notatum, KRV_005 Alternaria longipes and KRV_006 Trichoderma polysporum. Among them, KRV_001 Chaetomium oryzae, KRV_002 Penicillium citrinum, KRV_005 Alternaria longipes were maximum expressed α-amylase based on the plate assay by different pH, temperature and different substrate using amylase activity, SDS-PAGE, Antimicrobial activity has been done in Methanol extract exhibited antibacterial activity against S. aureus MTCC96 whereas the water extract displayed antibacterial activity. The organism produces volatile and water-soluble antibiotics and shows significant inhibition as the potential value of KRV_001Chaetomium oryzae and little less activity of KRV_006 Trichoderma polysporum among the isolates was...
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Posted by admin on Mar 31, 2022 in |
Aim: The present investigation deals with the preliminary phytochemical screening, in vitro antioxidant, and in vivo antidepressant activity of ethanolic leaf extract of Manilkara zapota. Materials and Methods: In-vitro antioxidant activity was evaluated using AS free radical scavenging parameters using Hydroxyl radical scavenging assay, phosphor molybdenum antioxidant assay and NO scavenging activity, and H2O2 scavenging assay. The forced swim test, tail suspension test and locomotor activity using a digital Photoactometer were used to investigate the extract’s antidepressant activity further. AA, fluoxetine (10 mg/kg) and imipramine (4 mg/kg, p.o) were used as reference drugs for comparison. Results and Discussions: The presence of these bioactive constituents is linked to the plant’s antioxidant and antidepressant activity. The IC50 values of Hydrogen peroxide and Hydroxyl radical scavenging were found to be 24.5 and 81.28 ug/ml for extract and 7.94 and 40.7 ug/ml for AA. In our study, the extract showed a significant (P< 0.01) reduction in immobility in the tail suspension and forced swim models of depression, comparable to imipramine. Conclusion: psychostimulant effect...
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Posted by admin on Mar 31, 2022 in |
The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. They provide good administration and enhance patient compliance. The present study aims to develop mucoadhesive microspheres of the model drug by using polymers like Sodium alginate and Carbopol 934 as an excellent mucoadhesive agent that can adhere to the gastrointestinal membrane for sustained drug delivery in the stomach. Calcium chloride was also used for making a solvent system. The preformulation study shows no interaction between drugs and excipients. The prepared microspheres of cimetidine particle size between 167.14-218.23μm. The entrapment efficiency of formulations was found to be 70.06-87.67%. In-vitro drug release after...
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Posted by admin on Mar 31, 2022 in |
The essential part of robots in the medical services framework is principal limiting individual to individual contact defilement and guaranteeing cleaning disinfection. Robots can be defined as an artificially intelligent physical systems capable of interrelating with the environment. The term robot was coined from the Czech what “robota” which implies serf/worker. Robots are classified as Receptionist robots, Surgical robots, Ambulance robots, Service robots, Telemedicine robots. During this pandemic, these mechanical frameworks can diminish the danger of irresistible illness transmission among forefront medical services laborers and afterward make it a potential advance to assess, accentuate, screen, and treat the patients from a safe distance, accordingly bringing down the responsibility of medical care staff. Robots are all around planned with UV light to sanitize the rooms and even themselves. Teleoperated robots in the medical care framework turn into the laborers’ eyes, ears, and bodies in the Isolation Ward, which might be dependable during this COVID-19 pandemic. This mechanical innovation will assume a vital part during this basic stage in certain spaces...
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Posted by admin on Mar 31, 2022 in |
A progressive neurodegenerative brain disorder with motor & non-motor are signs of Parkinson’s disease or idiopathic parkinsonism. Parkinsonism is characterized in striatal region by the deterioration of Substantia nigra pars compacta & dopamine depletion in Dopaminergic neurons. In Parkinsonism research, the prime purpose is to recognize the pathogenesis, strategies & implementation of therapeutic frameworks that regulate the disease progress. Versions of toxins are even starting to be used to anticipate what might arise in individual Parkinson’s disease. There is indeed, ton of advancement to be developed especially with reference to the design of experimental models which can precisely determine productive clinical neuroprotective substances. For Parkinsonism research, modern pharmacological, neurotoxin-induced, genetically altered & cellular models become presently accessible. Although caution should be exercised in the initial detection of neurodegenerative illnesses, data imply that future progress is secure, possible and probable to boost clinical care. In this overview, comprehensive information on key features of in-vivo & in-vitro models presently available has been...
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