Posted by admin on Feb 28, 2022 in |
The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex Mental health problems are characterized by in definite persistently depressed mood, low self-esteem, loss of interest in normal life activities. A common problems were the chances to occurs from generation to generation, i.e., genetic in nature, and these may also affect the child (age between 1 to 12 years old) with or without a family history of illness. There are different mental issues in the child such as anxiety, mood disorders, tic disorders, behaviour disorders, personality disorders; attention-deficit hyperactivity disorder (ADHD), depression, epilepsy, eating disorders, elimination disorders, and autism spectrum disorder (ASD) and these disorders can be hard for parents to identify due to lack of vocabulary or developmental ability to explain their condition. Most of the patient parents face the common problem is the “noncompliance to medication,” which is a major problem throughout the world, especially in developing countries where illiteracy, ignorance, poverty, and overpopulation are major challenges. These...
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Posted by admin on Feb 28, 2022 in |
This study looked at heavy metal levels in selected registered herbal drugs of Asian and unregistered Ghanaian herbal drugs sold in Kumasi. It examined the health risks of the metals. It provided authorities with data to ensure that herbal drugs are strictly monitored and their metal levels evaluated to safeguard patrons’ health. Dry ashing method was used on 10g of each of the herbal drug samples. Ashes were digested at 95 ºC with 70% HNO3 and 70% HClO4 (2:5v/v), and then metals were analyzed using Atomic Absorption Spectrophotometer (AAS). The Asian drugs recorded 27.42E-01 mg/kg (Fe), 28.17E-0 4 mg/kg (Pb), 27.43E-0 4 mg/kg, 12.06E-06E-0 2 mg/kg (As) and 79.72E-0 2 mg/kg (Cu) whilst the Ghanaian drugs recorded mean levels of 15.43E-01 mg/kg (Fe), 24.99E-02 mg/kg (Pb), 16.04E-03 mg/kg, 47.70E-0 4 mg/kg (AS) and 12.37E-0 4 mg/kg. Metal levels in drugs were below WHO and Pharmacopeia (China) permitted levels. HI and HQ were below 1, indicating that risk linked to the metals were...
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Posted by admin on Feb 28, 2022 in |
Background: Dengue is an arthropod-borne viral disease caused by the dengue virus (DENV). DENV is an RNA virus that belongs to the Flavivirus genus. The incidence of dengue has grown in the recent decade globally. The World Health Organization (WHO) considers dengue as a major global public health challenge in the tropic and sub-tropic nations. Materials and Methods: NS1 antigen and IgM antibody ELISA were done, and the serum levels of Vitamin-D and Mannose Binding Lectins (MBL) were determined to find out their association with the severity of Dengue, i.e., Dengue fever (DF) / Dengue Haemorrhagic Fever status (DHF). Results: The male-to-female ratio was 1.35:1 with the most commonly affected age group of 11-20 years (31.3%). NS1 antigen ELISA alone was positive in 12 (15%) samples, IgM ELISA alone was positive in 20 (25%) samples, while NS1 and IgM ELISA both were positive in 48 (60%) samples. 64 (80%) and 16 (20%) cases were DF and DHF, respectively. Conclusion: Thrombocytopenia is significantly notable in DHF patients as compared to...
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Posted by admin on Feb 28, 2022 in |
Background and Objectives: This study was carried out with the objective to investigate the antibacterial and antifungal activity of the bark of Hardwickia binata Roxb. Materials and Methods: Methanolic extract of bark of Hardwickia binata Roxb. exhibited an inhibitory effect towards the pathogenic organisms. Antimicrobial activity the zone of inhibition values of methanolic extract of bark of Hardwickia binata Roxb. in against two Gram-positive microorganisms viz. Staphytococcus aureus and Bacillus subtilis and two Gram negative microorganisms viz. Escherichia coli and Pseudomonas aeruginosa showed significant activity. Antifungal activity of methanolic extract of bark of Hardwickia binata Roxb. in against two microorganism, Candida albicans, and Aspergillus niger, showed significant activity. Results: The results showed that the remarkable inhibition of the bacterial growth was shown against the tested organisms. The phytochemical analyses of the plants were carried out. The microbial activity of the Hardwickia binata was due to the presence of various secondary metabolites. Conclusion: Hence, these plants can be used to discover bioactive natural products that may serve AS leads in...
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Posted by admin on Feb 28, 2022 in |
The aim of the present work is to develop and optimize solid lipid nanoparticles (SLNs) of pomalidomide with the aid of Box-Behnken design (BBD). A design space with three formulation variables at three levels was evaluated in BBD. Amount of lipid (A), surfactant (B), and co-surfactant (C) were selected as independent variables, whereas particle size (Y1), entrapment efficiency (Y2), and percentage drug release after 12 h (Y3) as responses. Pomalidomide-SLNs were prepared by hot emulsification/ ultra-sonication method and evaluated for responses to obtain optimized formulation. The effect of different levels of factors was evaluated for the particle size, PDI, zetapotential, entrapment efficiency, and % cumulative drug released. Kinetic model fitting for all pomalidomide SLN formulations was done to interpret the release rate. Characterization for the optimized formulation was done by FTIR, SEM, and stability studies. The optimized formulation PLF15 with 6% of tricapric as lipid, 6% of poloxamer 188 as surfactant and 2% eupikuron 200 of co-surfactant used in the nanoparticles with 126.59 ± 1.17 nm of size, 0.172...
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