Posted by admin on Feb 28, 2022 in |
The present study aims at analyzing the efficiency of allicin, agarlic derived phytochemical or neutraceutical in elevating the activities of various enzymic antioxidants on its treatment to cultured breast cancer cell lines. In the experimental work, cultured breast cancer cell lines were treated with different doses of allicin, and through standardized protocols, the cell lines were assayed for the activities of enzymic antioxidants such as Peroxidase, Superoxide dismutase, Catalase and Glutathione S Transferase as compared to untreated control. It was found that allicin treatment significantly increased the activities of the said enzymic antioxidants as compared to control. This study demonstrates the antioxidant potential of allicin in cancer cells, showing decreased antioxidant activity as a characteristic feature of cancer cells, leading to severe oxidation-induced damage. The study also proposes future prospects in the areas of cancer research and therapy to cobble for the designing of targeted plant-based therapies that are easily available and are cost effective in comparison to synthetic therapeutic chemicals and that too without side...
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Posted by admin on Feb 28, 2022 in |
Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heavy metals. They also provide aid in improving soil aggregation and soil stabilization, resultantly leaving a positive impact on ecosystem structure. The diversity of AMF varies among different habitats of the globe. The study of dynamics in the variety of these fungi in other host species in accordance with seasonal changes in a particular agro-climatic zone is significant to evaluate the natural status of these fungi in a specific region. It also becomes necessary to explore these fungal communities in different habitats for efficient utilization and conservation. The exploration of predominant AMF is also helpful in forming inoculums and its utilization for the production of better seedlings and their survival in adverse...
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Posted by admin on Feb 28, 2022 in |
In this review, we are completely discussing different eras in pharmaceutical drugs/medicines, i.e., Biologics and biosimilars. These biologics can be called life drugs because they are deriving from living organisms, microbes, yeast, bacteria, and human blood products. These biologics are biopharmaceutical products that are derived from living organisms and are very complex in molecular structure, and do have very high molecular weight. The synthesis of these biologics is completely different from the small molecule drugs that are chemically synthesized. These biologics are synthesized by recombinant DNA technology. As these biologics are patented, they won’t allow the copying of these products. But they are now expiring their patents and leading their way to the development of their close copies, i.e., Biosimilars. Biosimilars are the copies of the biological which has to be proven as highly similar to that of their branded biologics for their efficacy and safety and has to be developed after the expiring of the patent term period of the biologics, like the generic drugs for the branded...
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Posted by admin on Feb 28, 2022 in |
There is an urgent need to replace the injection currently used for low molecular weight heparin (LMWH) multi-dose therapy with a non-invasive delivery device. In this study, unsaturated polyester resin and peroxide were used to fabricate microneedle mould by using 3M microneedle. Dissolving microneedle arrays transdermal patch was prepared by using 20 % w/v polymers of PVA and PVP (polyvinyl alcohol and polyvinyl pyrrolidone) and active drug 20 mg (IU) low molecular weight heparin (LMWH). The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy suggested the absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to weight variation, drug content, folding endurance, percentage of moisture content and water uptake. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. The formulation prepared with PVP: PVA 1:2 showed best ex-vivo skin permeation through rat skin (Wistar rat) as compared to all other formulations. The release profile of the optimized formulation F2 (R2 =...
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Posted by admin on Feb 28, 2022 in |
Polygonum glabrum, commonly called dense flower knotweed, is a perennial plant found in most parts of India. The leaves of plants Polygonum glabrum Willd. Belonging to the family, Polygonaceae are a rich source of flavonoids and tannins but not yet scientifically investigated for antioxidant activity. The present study aimed to offer a novel scientific background to the leaves of Polygonum glabrum by evaluating it for antioxidant activity using in-vitro and in-vivo methods. The ethyl acetate and ethanolic extracts of Polygonum glabrum Willd. leaves showed significant antioxidant activity by using in-vitro models, which may be due to the presence of phytoconstituents such as polyphenol, tannins and flavonoids. Based on the in-vitro results, potent extracts were further evaluated for antioxidant studies by using in-vivo models. Acute toxicity studies were carried out as per OECD guidelines, and the doses were fixed at 200 and 400 mg/kg b.w. The ethyl acetate and ethanolic extracts at the dose of 400 mg/kg showed the degree of protection by measuring antioxidant enzymes CAT, SOD, non-enzymatic antioxidant...
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