Posted by admin on Jan 31, 2022 in |
Topical drug delivery is the conventional route of drug administration to the surface of the skin. Barrier present in the various layers of skin hinders the permeability of drug molecules, specifically large size of drug substance into the systemic circulation. A small-sized needle in micron range is found to be a promising approach to penetrate the uppermost layer of the skin i.e., epidermis to the dermal tissue. These needles are used in the delivery of drugs such as insulin, proteins, RNA and gene therapy due to the efficiency, convenience, safety, and painless nature of the needle. Moreover, the combination of non-carriers with the microneedle delivery system further highlights the application of these needles. This review will discuss the various types of microneedles (MNs) such as coated, solid, dissolving hollow and hydrogels for the effective delivery of drugs and the materials used as fabrication of microneedles. All the microneedles act differently to show its action such as solid MNs produce mini pores in the skin, whereas special channels will be...
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Posted by admin on Jan 31, 2022 in |
Marine environment is an exceptional storehouse of novel bioactive natural products that are mainly found in invertebrates such as sponges, arthropods, annelids, molluscs, etc. This diversity has been the source of unique chemical compounds. A large portion of these natural compounds has been extracted from marine invertebrates. Marine invertebrates are rich sources of bioactive compounds and their biotechnological potential attracts scientific and economic interest worldwide. Marine invertebrates are extremely diverse, largely productive, untapped oceanic resources with chemically unique bioactive compounds. Marine natural products are generally secondary metabolites. The number of natural products isolated from marine organisms increases rapidly. Isolated compounds from marine invertebrates have been shown pharmacological activities. They are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, an Acquired immunodeficiency syndrome (AIDS), osteoporosis and so forth. So marine life is fascinating and has great potential for the development of drugs. The present review aims to know about the bioactive compounds produced by marine invertebrates and their use and application in the...
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Posted by admin on Jan 31, 2022 in |
Background: Depression is becoming an important health problem worldwide because of its relatively high lifetime prevalence, significant disability, suffering, dysfunction, and economic burden caused by it. Objectives: The present study was conducted with the objective to determine the prescribing pattern of antidepressant drugs in patients suffering from depression disorder in the psychiatric outpatient department of a tertiary care hospital. Materials and Method: A prospective observational study was conducted to analyze the drug prescription pattern of the various antidepressant drug prescribed in Depressive Disorder. This study was conducted in psychiatric OPD of a tertiary care teaching hospital. Results: A total of 150 patients attending the psychiatric OPD were screened for the study. Among them, 75 were excluded as they had other psychiatric and medical illnesses. Out of 75 patients, 41 (54.7%) were males, and 34 (45.3%) were females. Most of the cases fall under the age group of 18 to 30 years. Escitalopram 48 (28.2%) was the most commonly prescribed antidepressant followed by sertraline 14 (8.2%), Paroxetine 5 (2.9%), Desvenlafaxine...
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Posted by admin on Jan 31, 2022 in |
The term “Naturals are the safer” is quite trendy, but the incomplete knowledge of the natural herbs interaction may result in several allergies and unwanted effects that may even take life and sometimes be critical to a life-threatening extent. The responsibility of the FDA is to ensure that the safety and efficacy of the drug consumed by humans and veterinary should be worthful and should cause no harm to their life. FDA also plays a vital role in the protection of public health by ensuring the effectiveness of the biological product and medical devices. Still, FDA does not show the same concern and guidelines for the efficacy and safety studies used for the common prescribed herbal drugs, dietary supplements, and marketing in the public domain. AS the favorability and likeliness of patients are inclining towards herbal remedies, there is increased production of such products. While manufacturing these products, the producers cannot submit the proof of safety and efficacy laid by the USFDA guidelines to the FDA before marketing. This...
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Posted by admin on Jan 31, 2022 in |
Depression is a significant contributor to the global burden of disease and affects people in all communities across the world. Today, depression is estimated to affect 350 million people. The World Mental Health Survey conducted in 17 countries found that, on average, about 1 in 20 people reported having an episode of depression in the previous year. Depressive disorders often start at a young age; they reduce people’s functioning and often are recurring. For these reasons, depression is the leading cause of disability worldwide in terms of the total years lost due to disability. Depression is known with some signs, such AS altered cognitive functions and mood, and is linked with a significant social dysfunction such as decreased quality of life. The demand for curbing depression and other mental health conditions is on the rise globally. A recent World Health Assembly called on the World Health Organization and its member states to take action in this...
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