Posted by admin on Jan 31, 2022 in |
Hoarding behavior is a normal phenomenon commonly observed in all corners of the world to prevent future scarcity of resources and overcome challenges of survival. Hoarding signs typically develop in childhood or early adolescence, which may become a serious disorder in the late phase of life. At present, hoarding disorder has been covered under the chapter of ‘Obsessive-Compulsive and Related Disorders’ along with obsessive-compulsive disorder, body dysmorphic disorder, trichotillomania (hair-pulling disorder), and excoriation (skin-picking) disorder as per DSM-5. Hoarding disorder (HD) is defined as a persistent difficulty discarding possessions, resulting in an accumulation of belongings, causing severe clutter and the congestion of living areas. HD appears to be a chronic problem that presents a burden on family and society. Pharmacotherapy of this disorder exhibits a gloomy picture since no approved allopathic medicines are available for its management. The best clinically proven way to manage hoarding disorder is with cognitive behavioral therapy, which motivates the patient specifically in addressing the key characteristics of this disorder. Recent lines of evidence suggest...
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Posted by admin on Jan 31, 2022 in |
Objective: The aim of the study was to develop osmotic tablets of nateglinide by two methods, namely elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) method for controlled drug release. Methods: Initially, pre-compression parameters were studies for the tablet blend in both EOP and PPOP methods. The tablets were prepared by the wet granulation method in both methods. The prepared tablets were evaluated for various physicochemical parameters, in-vitro dissolution, and the dissolution data were fitted into kinetic models for knowing the mechanism of drug delivery. The optimized formulation obtained in both methods was further characterized for FTIR and stability studies. Results: In EOP method, P1-P14 formulations prepared before coating exhibited 16h drug release, and after coating (F1-F14) all the formulations exhibited 24h prolonged drug release, with F14 showing the highest drug release of 98.82%. In PPOP method, in-vitro drug release depended on the effect of plasticizer, effect of drug layer to coating weight gain, and osmogen concentration. Finally, formulation FF14 was optimized with the highest drug release of 99.97%,...
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Posted by admin on Jan 31, 2022 in |
A new preorganized ligand, benzil bis [2-(2-amino-ethylamino) ethanol)] (H2BAE) has been synthesized and characterized for the first time. Copper (II) and cobalt (II) complexes of H2BAE have been synthesized and characterized based on molar conductivity data IR, UV-Vis spectroscopy. The complexes are found to have general formula M(BAE)2 (where, M = Cu (II) and Co (II). IR spectral data indicate that H2BAE acts as hexadentate ligand. The complexes are 6-coordinate and found to have octahedral structure; the copper complex is investigated using ESR spectroscopy at room temperature (RT) and liquid nitrogen temperature (LNT). The spin Hamiltonian, orbital reduction, and bonding parameters are calculated for the complex. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. Groove binding of complexes to DNA is suggested on the basis of deoxyribonucleic acid (DNA) binding constants and the variations in the absorption spectra of metal complexes in the presence of DNA. The copper complex binds DNA more strongly than cobalt complexes. Metal complexes are screened for their...
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Posted by admin on Jan 31, 2022 in |
Karnataka is a southern state of India with richer diversity of plants and nearly 20% of its land area occupied by forest. Geographically Karnataka state is divided into three major zones, Western Ghats (Sahyadri), Coastal region and the Eastern plains which harbor a diversity of medicinal plants that have been used in traditional medicine by tribes and various ethnic groups for their primary health care systems. Effective herbal folk therapy is a challenge as it requires the knowledge of plants, method of collection, mode of preparation, dosage and many other aspects of treatment. Traditional uses of medicinal plants for neuro-musculo- skeletal disorders in Karnataka specifically have not been reviewed. This review presents the ethnomedicinal plants used for the treatment of common neuro-musculo-skeletal disorders such as arthritis, rheumatism, epilepsy, lumbago, paralysis, sprain, migraine, insomnia, depression, bone fracture, psychosis, anxiety, schizophrenia, bipolar disorder and neural disorders by various ethnic communities of Karnataka. A total 327 species of plants belonging to 93 families have been reviewed and compiled. 325 of them belong...
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Posted by admin on Jan 31, 2022 in |
The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacological activities such as antidepressant, antihypertensive and cardiotonic etc. Some 7-phenyl-3, 4, 8, 9-tetrahydro-2H-pyridazino [1, 6-a] [1, 3, 5] triazin-2-imine were synthesized by reacting 6-Phenyl substituted 2, 3, 4, 5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The total seven compounds (vj1-vj7) were synthesized under Mannich reaction conditions. All the synthesized derivatives were selected for evaluation of antihypertensive activities by a non-invasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj4, vj5, and vj6 were found to show a highly significant...
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