Posted by admin on Jan 31, 2022 in |
Hypertension is a major global health challenge due to its prevalence and increased risk of cardiovascular disorder. Non-pharmacological intervention or lifestyle modification is a safer option to control blood pressure and shows effective results in regulating high blood pressure. In this review, we have described the pathophysiology of a hypertensive patient infected with severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) and functioning Angiotensin-converting enzyme 2 (ACE2) receptor during novel coronavirus disease 2019 (COVID-19). We summarized that article with the statement that hypertensive patients are more susceptible to SARS-CoV-2 not because they are taking ACE inhibitor drugs that regulate blood pressure and blocks angiotensin II-induced inflammation and tissue damage. Still, chronic drug intake makes their body weak to get infected with SARS-CoV-2 due to compromised immunity. Thus, lifestyle modification by taking healthy diet, regular, precise exercise, reducing stress, avoidance of salt intake, involvement of green leafy vegetables rich in potassium should be included in the meals, drinking of enough water (3-4 liters/day) daily, limitation in consumption of alcohol and caffeine make effectively...
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Posted by admin on Jan 31, 2022 in |
Objective: The present research was focused on designing, formulate and evaluate the trilayer matrix tablets incorporated with quinapril for extending drug release. Methods: Quinapril trilayer matrix tablets were formulated using response surface methodology wherein initially 27 formulations (QF1-QF27) were designed for active layer from which one best formulation was chosen based on drug content, swelling index, and in-vitro release studies. The chosen formulation was formulated into extended-release trilayed matrix tablet by varying proportions of polymers by direct compression technique and was evaluated for various physicochemical parameters, drug release and the drug release data were fitted into the various kinetic model to know the mechanism of drug release. The best-optimized formulation was further characterized by FTIR and stability studies. Results: 27 active layer formulations were evaluated for various physicochemical properties and drug release, out of which the highest drug release was exhibited by QF16 (98.85%). Thus, QF16 was used for formulation into trilayer matrix tablets (AQF16-HQF16). All the formulations were evaluated for drug content, swelling index, and percentage drug release...
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Posted by admin on Jan 31, 2022 in |
Lupeol (I) is a naturally occurring triterpene that has been isolated from the stem bark of Crataeva nurvala in appreciable amount. Due to the presence of a single hydroxyl group and a large, apolar skeleton, lupeol acts as an amphiphile. The two possible sites for chemical modification present in lupeol are ring-A and isopropenyl side chain. We modified it in three naturally occurring analogous derivatives, i.e., 3a, 5a, 5b, 8, 8, 11a-Hexamethyl-1-(2-methyl-oxiranyl)-icosahydro-cyclopenta[a] chrysen-9-ol (II), lupeol acetate (III), and lupenone (IV) by oxidation and acylation process. The structures of the newly synthesized compounds were confirmed by elemental analysis, 1H, 13C NMR, IR, and MS spectroscopy. In-vitro antioxidant activity for all the compounds evaluated where ascorbic acid (vitamin C) treated as standard. All the analysis was made with the use of UV-Visible spectrophotometer. Result of the study suggested that all the compounds showed effective efficacy for antioxidant properties in a concentration-dependant manner, although lupeol acetate was found most significant in comparison to...
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Posted by admin on Jan 31, 2022 in |
Cancer is a diverse category of diseases involving the growth of unchecked cells. Cancer cells uncontrollably divide and expand, creating malignant tumours that can invade surrounded parts of the body. Carbon nanotubes (CNTs) consist solely of a carbon atom organized into a tubular form in a sequence of condensed benzene rings. These sheets are rolled at a particular and distinct angle and the properties of the nanotubes are determined from the combination of the radius and rolling angle. Because of their non-toxic nature and high fluorescence characteristics, carbon nanoparticles are shaped into a ligand that is unique to a highly expressed receptor for imaging and drug conveyance in malignant growth care. Carbon specks (C-dabs) and carbon nanotubes (CNTs) are leading the continuous discovery of carbon-based nanoparticles. CNTs are used as nano-carriers for anticancer drugs, including carboplatin, camptothecin doxorubicin via proper...
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Posted by admin on Dec 31, 2021 in |
Quality by Design (QbD) is an essential part of modern pharmaceutical development. QbD is a requisite for the design and development process for the pharmaceutical industry. QbD assists and encourages both the industries and FDA to inculcate a proactive, scientific and risk-based approach in the process and product development. It is based on a concept of building quality right from the start of the process rather than the final quality test of the finished product. An effective QbD approach provides insights and essential upstream throughout the development process which ultimately ends up offering a successful plan that reduces batch failures and recalls. It is also known as a structured lifecycle of product development and management. This review aims to present an overview of QbD implementation, its tools, elements, and methodologies, the involved ICH Guidelines, and the application in the current pharmaceutical sector. Under QbD, it is important to define the desired product performance profile i.e., Quality Target Product Profile (QTPP) and analyze, Critical Quality Attributes (CQA), Critical Process Parameter...
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