Posted by admin on Jan 31, 2023 in |
The BSC sample was collected at four sites from the arid region of Rajasthan and these isolates were characterized based on morphological and biochemical parameters. We have to isolate both heterocysts and non-heterocysts cyanobacterial species. Oscillatoria tenuis species showed maximum chlorophyll accumulation and Phormium showed maximum carotenoids compared to heterocystous forms. The soluble protein content is high in Non-heterocystous Phormium and Oscillatora curviceps and lowest in heterocystous Nostoc linckia. Heterocystous forms Nostoc commune and Anabaena variabilis were synthesizing high carbohydrates compared to nonheterocytstous forms. Highest nitrogenase activity in Nostoc linckia isolated from Achorl...
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Posted by admin on Jan 31, 2023 in |
Malaria is the most important parasitic disease in humans, with transmission occurring in over 100 countries with a population of three billion people. Protozoan parasites of the genus Plasmodium cause it. These parasites are transmitted from one person to another by the female anopheles mosquito. Medicinal plants possess many phytochemicals of great therapeutic value, and many effectively kill malaria parasites. These compounds working by variety of mechanisms and in most of the cases they exhibit their antimalarial potentiality by inhibiting many proteins involved in cell growth and division. Molecular docking is a computational approach which facilitates the finding of the best molecule from a group which may bind with the highest affinity with the intended target by providing a virtual biological system. This process works on the basis of specific algorithm and involves scoring function to rank the molecules that fit with the target. The present study has been designed to investigate the antimalarial potential of seven alkaloid compounds from the leaves of Bauhinia purpurea. Three standard antimalarial drugs...
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Posted by admin on Jan 31, 2023 in |
This work aimed to explore how crude aqueous extract of Jussiaea repens affected oxidative stress and metabolic status in streptozotocin (STZ) induced diabetic male rats. The diabetic rats were gavaged with aqueous extract of Jussiaea repens (50 mg/100 g body weight/day for 32 daysconsicutively) after an induction of STZ (8 mg/100g body weight, i.p.). Fasting blood glucose, insulin, serum LDH, total GSH, MDA, G-6-PDH, amylase, lipase, catalase and superoxide dismutase were measured. The hepatic levels of hexokinase, PFK, G-6-Pase, F-1,6-BPase and glycogen were also measured. The aqueous extract of Jussiaea repens decreased blood glucose level in diabetic control group. The extract supplemented group also demonstrated a notable improvement in blood insulin levels, SOD, GSH and G-6-PDH level in comparison to diabetic group. In diabetic group, the LDH and MDA levels were significantly higher than non-diabetic control rats and were significantly recovered in extract supplemented group. But catalase level showed no significant change. The liver glycogen, hexokinase and PFK were lower in the diabetic group, whereas G-6-Pase and F-1,6-BPase were...
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Posted by admin on Jan 31, 2023 in |
Diabetes Mellitus is a prevalent global health problem commonly known as diabetes, a metabolic disease resulting in high blood sugar levels. India considered as “Capital of Diabetes” and more than 61 million Indians suffer from diabetes. Plants are incredible natural reservoirs of phytochemicals and vital medicines. Momordica charantia (MC), commonly known as bitter melon, has high phytochemical content and is effective against diabetes mellitus. Momordica charantia is also considered as “vegetable insulin” because it contains alkaloids and peptides which resemble insulin and Charantin, which are responsible for the hypoglycaemic activity. The mechanism of action of bitter melon has been discussed and mentioned. Medicated Momordica charantia chewable lozenges are intended to dissolve or disintegrate slowly in the mouth and release the active constituent slowly because the Lozenges dosage form has good oral retention time in, increases bioavailability, and decreased gastrointestinal irritation. This dosage form can be used for both local and systemic therapy. Our hypothesis revolves around the formulation of Momordica charantia chewable lozenges for treating diabetes mellitus. Various shreds...
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Posted by admin on Jan 31, 2023 in |
Enzyme Alanine racemase is well known for performing a predominating role in mycobacterium cell wall synthesis. D-alanine provided by Alanine racemase serves as a peptidoglycan precursor, utterly vital for maintaining the growth and integrity of the cell wall. The lipid-rich mycobacterium cell wall is prevalent amidst prokaryotes with immense potential of becoming a therapeutic target for new drug discovery. The imperative role of Alanine racemase in mycobacterium cell wall synthesis implies that its inhibition is of uttermost priority in order to deal with various pathogenic infections. Interference with metabolic processes, lack of specificity, and cellular toxicity caused by several known inhibitors prompted renewed efforts by researchers to discover new and improved inhibitors with better therapeutic indexes. This paper provides an overview of the updated status of reported Alanine racemase inhibitors based on shreds of evidence in literature so that more precise inhibitors could be explored, designed, and identified to rationalize the overall drug discovery process, which will be true serendipity for the...
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