Posted by admin on Dec 31, 2022 in |
In this study, a series of novel Synthesis of (2,4-dimethoxy-3-((3- phenyl-4, 5- dihydroisoxazol-5-yl) methoxy) phenyl) (phenyl) methanone (8a-p), were synthesized from condensation of an equimolar quantity of aryl (3- hydroxy-2, 4-dimethoxyphenyl) methanones (4a-d) and 5-(bromomethyl)-3- phenyl-4,5-dihydroisoxazole (7a-d) in DMF solvent by employing anhydrous potassium carbonate (K2CO3) as a base. The chemical structure of the newly synthesized compounds was characterized by analytical and spectral (1HNMR, 13CNMR and HRMS) techniques. The desired title compounds were screened for qualitative (zone of inhibition) analysis by agar well method, respectively. Among the synthesized compounds in the series, the compounds 8b, 8c, 8f and 8l were found to show major antibacterial activity at a lower concentration, against Gram-positive bacteria such as Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria such as Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The rest of the compounds exhibited ample antibacterial activity compared to Chloramphenicol’s standard positive...
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Posted by admin on Dec 31, 2022 in |
The present study has been conducted to search out the anti-oxidative and anti-inflammatory potential of leaves of Camellia sinensis L. oil (Tea oil, TO). Forty-eight rats were included for 14 days experiment namely: Group I was normal to control, Group II was vehicle control, and Group III to VIII rats were subjected to paracetamol at the dose of 15 mg/ kg body weight/day to induce oxidative stress and inflammation (OS and I rats). Group IV to VII rats orally received TO at the dose of 100, 200, 400, 800 mg/kg, respectively and Group VIII received olive oil at 400 mg/kg. Paracetamol causes a significant (p < 0.05) increase in plasma urea, creatinine, glutamine-oxalic-transaminase, glutamate-pyruvate-transaminase, alkaline-phosphatase, interleukin-18 and tissue-injury-molecule-1, malondialdehyde and degeneration of hepatic cells in case of only OS and I rats. But treatment with TO in different doses showed a significant (p < 0.05) decrease above said parameters. We observed a significant (p < 0.05) decrease in superoxide dismutase, catalase, interleukin-10 levels in OS and I rats and...
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Posted by admin on Dec 31, 2022 in |
Carbon nanomaterials belong to the carbonaceous family of less than 10 nm in size called Carbon dots (C-dots); the latest class of engineered nanoparticles has recently gained popularity for their unique characteristic features, such due to their low toxicity and miniature size, it can penetrate cells easily, thus becoming highly biocompatible. The advancement of science and its collaboration with multidisciplinary fields for developing C-dots, their characterization, and application into the faster, cheaper, and more reliable products in various scientific areas. C-dots synthesis uses biomass wastes because of their abundance, wider availability, low cost in terms of higher production rate, non-toxic and eco-friendly. Here biomass has been used as a carbon source from renewable raw materials, such as plant and animal derivatives, agricultural wastes, etc. This review aims to summarize the upgrading and recycling of biomass waste to produce C-dots, sources of biomass wastes, characterization of structure and composition, regulation of fluorescence, heteroatom doping, and its unique photoluminescence and chemiluminescence characteristics that make the C-dots most promising nanomaterial used for...
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Posted by admin on Dec 31, 2022 in |
Gradual vision loss is linked to degenerative changes and cataract. The Isotine-herbal eyedrop has been clinically used for 36 years with a claim to reverse the cataract-induced visual impairment. This retrospective observational study on 308 cataract patients, registered between 2017 to 2019 at Basu Eye hospital, Bareli, UP, India, having 3 months of treatment, shows the significant therapeutic response in uncorrected distance visual acuity (UDVA) based on logMAR mean before and after treatment (P<.001). The improvement has been observed in patients having UDVA 0.1 to 1.7 and in UNVA from N-6.1 to N-36and above. Patients of partial vision impairment, having logMAR up to 0.99, significantly attained either normal vision or below 6/18 (logMAR- 0.47). In 103 patients of severe vision impairment (logMAR mean 1.0 to 1.77, considered as Blind by WHO), only 40 patients did not respond, but the remaining 63 patients attained a logMAR mean below logMAR-0.8. In the case of UNVA, 169 patients had vision between N-12 to N35, but after treatment, either they got normal vision...
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Posted by admin on Dec 31, 2022 in |
The day-by-day escalation of different diseases worldwide increases the demand for newer drugs with better therapeutic effects. Nature attracts researchers due to its rich herbal sources with potent effects against various diseases. Sesame seed acts as a reservoir for various bioactive components, exhibiting tremendous beneficial effects on human health. Sesame seed is not just only seeds that are consumed by the different parts of India but also plays an important into the lives of different communities, in their culture, and in the traditional system of medicine. Lignans are the major bioactive components of sesame seed reported to have many properties such as anti-diabetic, antioxidant, anticancer, and anti-inflammatory activities. Because of the oxidative coupling of β-hydroxyphenyl propane, different lignans are formed, such as Sesamin, Sisamol, Sesamolin, sesaminol. Due to the presence of multifarious bioactive components in sesame seeds, such as phenolic components, flavonoids sesame seeds bear a possibility to be an agent in controlling diabetes and hyperlipidemia by decreasing oxidative stress and inflammatory responses. This review focuses on the functional...
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