Posted by admin on Dec 31, 2022 in |
Alzheimer’s disease, the most scattered neurodegenerative disease causes progressive destruction in serviceable performances and continuous reduction in cognitive activities and memory in aged people. It is estimated that people suffering from AD is about 10% between 65-70 years and 50% in people above 85years of age and this number will double every two decades. Even though extensive research has been carried out for decades, there is no specific therapeutic drug available for the permanent cure of Alzheimer`s Disease. In this study, squalene, a natural compound synthesized from marine shark liver oil is selected to evaluate its Anti-Alzheimer’s properties in Experimentally AD-induced Male Albino Rats. In the present study, in-vivo experiments were carried out to test the Anti-Alzheimer’s property of Squalene on Male Albino Rats under D-galactose-induced AD. The estimation of ACh and AChE content in the Cerebral Cortex and Hippocampus was done in different groups of rats at different time intervals. The results revealed that in experimentally AD-induced Rats, Squalene caused significant ACh content elevation while reducing AChE activity...
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Posted by admin on Dec 31, 2022 in |
Liposomes are considered to be safe for usage; they have been used hugely in cosmetics. Biologically obtained compounds of phospholipids have a high affinity to the skin’s surface. Liposomes are highly permeable and have more storage capacity on the stratum corneum and also it is considered a chemically active agent to the skin. Most future studies on liposomes involve drug delivery in cosmetics. Liposome formulations are prepared from phospholipids of variant sources like egg and soya; they were differentiated in terms of their result on the skin like water content, Elasticity, Barrier function. Liposome has a variety of phospholipids giving a variety of effects on the skin humanity. Antioxidant and anti-inflammatory activity is a category poses by the plant of phenolic compound metabolite. The ideal property of the compounds are stable and also act as a bioactive ingredient in plants, but it will give the property after the process of extraction; they are considered to be very sensitive to light and heat sources; they have the property like speed...
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Posted by admin on Dec 31, 2022 in |
To solve the problem of low drug availability in the body, acyclovir was fabricated into biodegradable gelatin nanoparticles by step-wise two-times desolvation method where gelatin was used as biodegradable polymer and glutaraldehyde was utilized as a cross-linking agent. Optimization was conceded by design expert computational application whereby the outcome of gelatin polymer concentration (X1) and glutaraldehyde-crosslinking agent (X2) were studied on particle size (Y1), zeta potential (Y2), and entrapment efficiency (Y3). The drug-loaded gelatin nanoparticle formulations were characterized by particle size, surface charge, and entrapment efficiency. ANOVA studies also evaluated drug-loaded gelatin nanoparticles. The optimized formulation (F9) of 0.8% gelatin polymer (X1) and 250 μl of glutaraldehyde-crosslinking agent (X2) containing acyclovir: gelatin ratio of 1:8, which showed a particle size, zeta potential and maximum entrapment efficiency of 139.87 nm, -32.67mv and 91.23%...
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Posted by admin on Dec 31, 2022 in |
Anustrca annlipes (fiddler crab), often called crab, are decaped crustaceans of the uca family. They belong to the ocypodidae family, which contains over a hundred species of semi-terrestrial sea crabs. 11 of the 13 genera in the ocypodidae crab family are made up of more than 100 fiddler crab species. The species can be found on sea and brackish intertidal mud flats, lagoons and swamps, mangroves, salt marshes, and sandy or muddy west coasts. Anustrca annlipes also promotes the turnover and mineralization of critical nutrients and several species-specific body colour patterns that can act as intra- and intra-specific signals. Compared to female and smaller male uca annulipes crabs, they excavate their tunnels. An antimicrobial is a substance that kills or inhibits the development of bacteria. Antimicrobial medications are classified based on the bacteria they predominantly target. Through review number of antimicrobial proteins from Anustrca annlipes were identified. So the antimicrobial protein enolase from Anustrca annlipes sequence was retrieved from NCBI databases. Gene annotation was carried out by using amigo...
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Posted by admin on Dec 31, 2022 in |
The most commonly used analytical method in drug research is reversed-phase high-performance liquid chromatography (RP-HPLC). RP-HPLC methods also use huge quantities of solvents and generate by-products that must be disposed of, posing environmental and operator health worries. Micellar Liquid Chromatography (MLC) is a green chromatographic process for pharmaceutical analysis in which surfactants are applied above the Critical Micellar Concentration in the mobile phase (CMC). The ability of micelles to solubilize compounds that are not soluble or sparingly soluble in water is one of their properties; this property is critical for advancing analytical methods. MLC is also compliant with current RP-HPLC systems. As a result, no changes to the current RP-HPLC instrument are needed. MLC (micellar liquid chromatography) is a green and long-term method for analyzing medication compositions. MLC is not only the more environmentally friendly option, but it is also the more cost-effective. It is believed to have a mobile phase of 90% or more water (v/v), which can be recycled if injection volumes are small and far apart....
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