Posted by admin on Dec 31, 2022 in |
Poisonberry is the colloquial name for Solanum indicum Linn. It grows to over one meter in height and is thorny and densely branched. It is usually found in India’s warmer regions, up to an altitude of 1500 meters. This important medicinal plant treats respiratory infections, skin infections, ulcers, dyspepsia, cough, and stomach discomfort in Ayurveda and Siddha, the Folk and Traditional Indian systems of medicine. The findings of evidence-based tests are compared to the folkloric use of Solanum indicum Linn. Despite being a rich source of solanine, one of the plant’s most feared poisons, Solanum indicum has proved its value as a reservoir of antioxidants with hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory properties. The evaluation examines whether or not proper scientific methods have been followed in developing experimental evidence supporting Solanum indicum traditional applications, including in-vitro, in-vivo, and clinical trials. The study’s goal is to compile the most recent information on pharmacognostic research, medicinal purposes, chemical constituents, and other pharmacological effects. Solasodine, Solamargine, Solasonine, Solanine, and Solanidine were...
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Posted by admin on Dec 31, 2022 in |
Natural plant-derived compounds have been an essential resource in the evolution of drug discovery since the dawn of time. Using plants as a source of medicine is a century-long-standing tradition not merely in India but also in the entire world. North-East India is bestowed with incredible biological richness. The current research is focused on the histological and phytochemical analysis of four potent plant species collected from Goalpara district of Assam that is widely used in treating skin disorders. The four medicinal plants were collected based on traditional knowledge. The plants were evaluated for the identification and histochemical localization of effective phytochemicals following the standard protocols. Qualitative phytochemical analysis revealed the presence of important phytoconstituents responsible for different biological activities, including dermal activity. The histological study further showed the localization of phytochemicals, alkaloids, terpenoids, tannins, phenolics and flavonoids in all four plants. From adults to neonates, skin disorders are a major problem, especially in developing countries. Dermatological problems often deal with costly medications. The present study indicates that the studied...
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Posted by admin on Dec 31, 2022 in |
Breast cancer (BC) is one of the most prevalent cancers in women; there were 2.3 million women diagnosed with breast cancer globally. Unfortunately, most anticancer drugs have reported high Potential toxicity, mutagenic and carcinogenic side effects. Existing treatments can neither stop its propagation and/or recurrence nor are specific for cancer cells. Hence the side effects on healthy tissues and cells are common. There is a need to improvise the patient’s quality of life and the efficiency of the treatments, which can be potentiated with reduced toxicity. Nanotechnology has vast applications in diagnosing, treating and preventing breast cancer. Nanotechnology offers new alternatives for the design that can be used in cancer treatment and has now become a very promising tool for its use against breast cancer. In this review, we provide a broad overview on the use of nanotechnology in the fight against breast cancer. We have analyzed the latest research (2019-2021) in nanotechnology as a potential step for breast cancer treatment. We also give a brief summary of the...
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Posted by admin on Dec 31, 2022 in |
Current work makes known that Liquid Chromatography-Mass Spectrometry (LC-MS) method development and validation for the impurity G (N, N -dimethylpyridin-4-amine) and impurity S (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) methoxy] ethyl N-[1,1-dimetylethoxy) carbonyl]-L-valinate) in Valaciclovir Hydrochloride Hydrate active pharmaceutical ingredient (API). The developed LC-MS analytical method is complimentary to the thin layer chromatography (TLC) method available for impurity G and impurity S quantitation in the Valaciclovir Hydrochloride Hydrate API monograph. Impurity G and Impurity S were determined by the LC-MS method in Q1 Multiple ion mode using Ascentis Express C18 (15cm X 4.6 mm) 2.7µm analytical HPLC column. A gradient system was employed for the elution of analytes using acetonitrile (Eluent B) and 0.01M Ammonium Formate, LC-MS compatible volatile buffer, pH 3.0 (Eluent A) in distinct compositions. The gradient system (T/%B) was applied as 0.01/5, 4.00/5, 7.50/80, 10.00/80, 12.50/5, and 20.00/5. A method developed was validated considering the International Conference on Harmonization pharmaceutical guidelines. The quantitation limit found for Impurity G and Impurity S were 207.20ppm and 216.00...
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Posted by admin on Dec 31, 2022 in |
Recently, scientific investigations of medicinal plants using indigenous medical systems have attracted a lot of attention in international investigation. Nature has imparted our planet with an enormous wealth of medicinal plants known for bestowing and are highly esteemed worldwide as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Herbal drugs can be potential drugs to replace them. Every year, many plants from the traditional medicinal system may be screened for their potential analgesic activity. Still, only a few of them only included in the health care system after clinical research. So this is time to give more emphasis on research work based on natural sources, investigate the active phytochemical constituents, and use them on a specific...
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