Posted by admin on Dec 31, 2022 in |
Drug addiction has become a worldwide problem and the leading cause of death. In recent years, India is seeing a rising trend in drug addiction. The most common drug use in India is alcohol, followed by cannabis and opiates. Drug use, whether licit or illicit, causes serious health problems in individuals. The national survey on drug use in India indicated that the prevalence of drug abuse among males in the general population is significant. Economic burdens disturbed family environments, violence, and psychological problems are other consequences of drug abuse in the family. Adolescent drug abuse is another major area of concern because more than half of the person’s with substance use disorder are introduced to drugs before the age of 15-year Drug treatment is intended to help addicted individuals stop compulsive drug seeking and use. Treatment can occur in a variety of settings, take many different forms, and last for different lengths of time. Because drug addiction is typically a chronic disorder characterized by occasional relapses, short-term, one-time treatment...
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Posted by admin on Dec 31, 2022 in |
Glibenclamide belongs to a group of medicines called sulfonylureas. Glibenclamide is used to manage diabetes. Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. The purpose of the present study was to formulate an Oral dispersible tablet of Glibenclamide using the Solid dispersion technique through using polyethylene glycol ratio as a water-soluble carrier. The solid dispersion of Glibenclamide was prepared by using fusion methods. The characterization of Glibeclamide solid dispersion powder was done by using several parameters like bulk density, tapped density, Carr’s Index, Hausners’s ratio, drug content, solubility and in-vitro dissolution study. While the oral dispersible tablet was prepared by using direct compression method. The prepared tablets were evaluated for disintegration time, moisture content, friability, and wetting time. From this study, it can be concluded that fast disintegrating tablets could be a potential drug delivery technology for managing diabetic...
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Posted by admin on Dec 31, 2022 in |
Purpose: The present study has been designed to investigate the protective effect of methanolic extract of Albizia odoratissima (AO) bark in prevention of streptozotocin (STZ) induced-diabetic nephropathy (DN) in Wistar rats. Methods: Healthy Wistar rats of either sex weighing 180-200g were employed in the present study. Experimental diabetes was induced in rats by injecting STZ at a dose of 45 mg/kg (i.p.). Assessment of DN was done by estimating glucose level in blood and urine samples. Moreover, different antioxidant parameters like catalase, superoxide dismutase (SOD) and thiobarbituric acid reactive substances (TBARS) in kidney tissue samples were assessed. Additionally, inflammatory cytokines like interleukin-1 (IL-1), transforming growth factor beta (TGF-β), and tumour necrosis factor-alpha (TNF-α) were assessed in renal tissue. Results: Methanolic extract of AO bark (AOB) has shown significant prevention against diabetes-associated nephropathy. The bark extract decreased glucose levels both in urine and blood sample. The AO extract, either alone or in combination with a standard drug (glibenclamide) showed a significant reduction in oxidative stress in renal tissue, as demonstrated...
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Posted by admin on Dec 31, 2022 in |
Background Diclofenac Potassium is the potassium salt form of diclofenac, a benzene acetic acid derivate, and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Aim: Therefore, the purpose of the present study was to formulate and evaluate liquid-filled hard gelatin capsules of diclofenac potassium. Methods: The liquid-filled soft gelatin capsules were prepared by using PEG 400, propylene glycol and water mixture under temp of 900 C followed by adding PVA, Cremophore EL, Labrasol and in last diclofenac potassium was finally added to the mixture under stirring. The final formulation was filled in a hard gelatin capsule, and the hand band seal was performed. Physico-Chemical Evaluation: A total fifteen liquid-filled hard gelatin capsule formulations were prepared (F-1 to F-15) and evaluated for weight variation test, lock length, drug content, nephelometric turbidity units (NTU) and in-vitro release study. Results: The drug content ranged from 92.76±0.12 to 99.25 ±0.19. The results indicated that the drug content was uniform in all the formulations. The disintegration time ranges from 130 sec to 232 sec. In-vitro dissolution study...
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Posted by admin on Dec 31, 2022 in |
A periodontal disease is a group of pathological diseases, i.e., a widespread infectious disease that mainly causes tooth loss in 15% of adults worldwide. For the treatment of these periodontal diseases, localization of the drug is necessary i.e.; the drug has to be delivered to the periodontal pocket, which is the main area for the development of bacteria. So, researchers have made many attempts to develop the treatment of periodontal disease, including drug delivery to the infection site and regeneration approaches; they really provide a useful experimental mode for evaluating therapies for future periodontal diseases. This review mainly focuses on the pathogenesis of periodontal diseases, the process of fabrication of nanofibers using electrospinning techniques, and mainly how these electrospun nanofibers are used in the treatment of periodontal diseases. And gives an overview of how antibiotics, antimicrobial agents, and nanocomposite electrospun nanofibers are used in the treatment of periodontal...
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