Posted by admin on Dec 31, 2022 in |
Three-dimensional printing (3DP) is an imminent technology used to describe 3D products generated using a digital design platform manufactured layer by layer. This technology appears to be a transformative tool. It has just emerged as a key technological breakthrough, allowing the pharmaceutical sector to develop and generate new pharmaceutical items and equipment. It’s a brand-new way to personalize pharmaceutical formulation and design. Spiratam® (levetiracetam), the first commercial 3D tablet, was approved by the FDA in August 2015, sparking a rise in interest in employing this platform for pharmaceutical development. Following the FDA’s approval of the first 3D printed tablet, Spritam. The concept can benefit patients, pharmacists, and the pharmaceutical business by enabling the on-demand design and fabrication of flexible formulations with customized dosages, forms, sizes, drug release, and multi-drug combinations. This is a watershed moment in the history of 3D printing in pharmaceuticals, needing the involvement and assistance of healthcare professionals like pharmacists, doctors, nurses, and pharmacy technicians, among others, to enable wider use of the technology. This article...
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Posted by admin on Dec 31, 2022 in |
To investigate the hepatoprotective activity of Coccinia grandis fruit extract against anti-tubercular drugs induced hepatotoxicity in rats. 50% ethanolic extract of Coccinia grandis (CGE 200 and 400 mg/kg body weight) was administered daily for 9 days in experimental animals. To develop hepatotoxicity, animals were administered orally with Isoniazid (50 mg/kg, p.o.) and Rifampicin (100 mg/kg, p.o.) at 2 h after the doses of CGE every day for nine consecutive days except for rats in the normal group. The hepatoprotective activity was determined using different biochemical parameters such asalanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin (ALB), Bilirubin (BIL), Cholesterol (CHL) and lactate dehydrogenase (LDH). Histopathological examinations further accomplished the hepatoprotective effect of the CDE. The results obtained demonstrated that the treatment with Coccinia grandis significantly (P<0.05-P<0.001) and dose-dependently prevented the drug-induced increase in serum levels of hepatic enzymes. Histopathology of liver tissue showed that Coccinia grandis attenuated the hepatocellular necrosis, regeneration, and repair of cells toward normal. The results of this study strongly indicate the protective effect of...
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Posted by admin on Dec 31, 2022 in |
A simple, specific, accurate, reliable, and precise reverse-phase high-performance liquid chromatographic method was developed by quality by design approach and validated for the estimation of Capecitabine in bulk and tablet dosage forms. A surface methodology was used to optimize the data with a three-level Box Behnken Design (BBD) was used. Mobile phase composition, flow rate, and column oven temperature were chosen as the three variables. The linearity was over the concentration range of 1-15 μg/ml with a correlation coefficient of 0.999. The LOD and LOQ were found to be 0.103 ug/mL and 0.313 ug/mL, respectively. Chromatographic separation was carried out by using a mobile phase of methanol: water (70:30 V/V) on Kromasil C18 column (250 mm X 4.6mm ID, 5 μm) in an isocratic mode at a flow rate of 0.9 ml/min with UV detection at 239 nm. The developed RP-HPLC method yielded a suitable retention time for Capecitabine of 4.70 min, which was optimized using the Design-Expert version 7.0.0. The percentage recovery was found to be 99.81%. The...
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