Posted by admin on Oct 31, 2023 in |
Periodontitis is a complex infectious disease of supporting structures of teeth caused by specific microorganisms or groups of microorganisms. Formation of a new connective tissue attachment and bone deposition are the main goals of periodontal therapy. The excisional new attachment procedure (ENAP) is especially sub-gingival curettage performed with a knife performed by internal bevel incision performed and excision of tissue. It is indicated in localized, mild to moderate periodontitis, mainly in the anterior region. The main advantage over traditional curettage is the definitive, clean excision of the junctional epithelium and the adjacent tissue with a greater probability of new clinical attachment. The post-surgical recession and root sensitivity are minimized by using this technique. There is no significant tissue loss in this procedure. The benefits of the excisional new attachment method in periodontics are emphasized in this...
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Posted by admin on Oct 31, 2023 in |
Inflammation and pain have all been successfully treated using nonsteroidal anti-inflammatory drugs. Today’s nonsteroidal anti-inflammatory drugs (NSAIDs) are typically taken with restriction due to the gastric intolerance they create. The prodrug approach is quite effective in reducing the side effects caused by NSAIDs. Many nonsteroidal anti-inflammatory drug molecules have been modified in several ways so that they can be less hazardous to the stomach. Using the mutual prodrug concept, the side effects can be minimized by covalently bonding the NSAIDs to the second pharmacologically active carrier. The goal of the current study is to use the coupling approach to create mutual ester prodrugs of NSAIDs (MS and MP) in order to overcome the troubles, they cause, like gastrointestinal toxicity, ulcerogenic side effects, etc. The prodrugs were made by using a better reagent, EDAC 1-Ethyl-3-(3-Dimethylaminopropyl) carbodiimide hydrochloride, because it outperformed DCC (N, N′-Dicyclohexylcarbodiimide) as a coupling agent. The physiochemical properties were determined, and the structures of the synthesized prodrugs were confirmed and analyzed by UV, FT-IR, 1HNMR, 13CNMR Spectroscopy and...
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Posted by admin on Oct 31, 2023 in |
Dissolution is an authorized test used by Pharmacopoeias for assessing drug arrival of solid and semisolid measurement structures. The primary utilization of dissolution testing incorporates the biopharmaceutical portrayal of medication items as a device to guarantee reliable item quality and to predict in-vivo drug bioavailability. Dissolution testing was initially grown for solid orals; later on, its utilization was enlarged to an assortment of novel dose structures. Because of the intricacies in the medication conveyance of novel dose structures, there is a need to create changed dissolution testing strategies to describe the in-vitro arrival of these measurement structures. The article addresses the ongoing updates in dissolution testing strategies for ordinary and novel drug measurement structures and gives knowledge of potential choices in drug dissolution testing plans. This survey addresses all potential state-sanctioned test techniques expected to describe the dissolution properties of a wide assortment of measurement structures going from customary to novel...
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Posted by admin on Oct 31, 2023 in |
Introduction: Balance is an integral component of daily (functional) activities. It is very sensitive, complex and multifactorial. It is the ability to maintain the projection of the body’s centre of mass within manageable limits of the base of support, as in the standing or sitting or in transit to a new base of support, as in walking pattern (1). In old age ability to maintain balance is low and fall is frequent. Objectives: To determine the efficacy of balance training over old age individuals. Inclusion Criteria: Age > 65 years, no gender difference, independent ambulation and activity of daily living. Exclusion Criteria: Chest pain, cancer, amputation, cognitive impairments, neurological condition, fractures. Methods and Procedure: This study was conducted among 50 elderly people. It is randomized control trial, allocated into 2 groups as follow; experimental group and control group. Intervention was given to the subjects 3 times per weeks in 8 weeks. Subjects were assessed before and after. Control group activity included either usual activities or recreational activities. All participants...
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Posted by admin on Oct 31, 2023 in |
Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine used for the treatment of acute manic and mixed episodes associated with bipolar I disorder. In the present study bilayer tablet was developed to improve dosing convenience and decrease daily fluctuations in serum CBZ concentration, thereby lowering the incidence of adverse events. In bilayer tablet one layer provided the loading dose by immediate drug release and another layer provided maintenance dose up to 12 hrs by sustained release. The drug excipient compatibility study was carried out by FTIR and DSC techniques, there was no interaction found. Cross povidone was used as superdisintegrant in immediate release layer and controlled release fraction was formulated by using HPMC K 100 polymer. The prepared granules were evaluated for angle of repose, bulk density, tapped density and compressibility index which showed satisfactory result. The prepared bilayer tablets were evaluated for thickness, hardness, friability and in-vitro release studies. In-vitro dissolution study was carried out for 12 hours using USP dissolution apparatus I using...
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