Posted by admin on Sep 30, 2023 in |
Diabetes mellitus is a group of disorders that speed up the metabolism of protein, fat, and carbohydrates. It has been forecasting rises in the incidence and prevalence of diabetes mellitus in recent years. Different plant parts have historically been used to treat diabetes mellitus. The Plant Gmelina arborea (lamiaceae) treats insecticidal, antidiuretic, anti-diabetic, anti-analgesic, and immunomodulatory activity. Basella rubra (Baellaeceae) is used as an Androgenic, diuretic, emollient, demulcent and anticonvulsant. Sphaeranthus indicus (Asteraceae) treats ananxiolytic, neuroleptic, antioxidant, anti-inflammatory, bronchodilatory, antihyperglycemic and hepatoprotective. The plants were processed, powdered and extracted with hydroalcoholic solvent. Maceration was processed for 72hrs, 48 hrs and 24 hrs. Solvents were filtered, distilled, and dried in a vacuum desiccator. Polyherbal formulations such as BSG, SBG, BGS were made by taking the required proportion of each powdered drugs. The in-vitro anti-oxidant and anti-diabetic potential of plant were determined by DPPH radical scavenging activity, Alpha-amylase and Alpha-glucosidase inhibition assay. The activity reported that hydroalcoholic extract of Gmelina arborea, Basella rubra, and Sphaeranthus indicus exhibits potent activity indose–dependent manner....
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Posted by admin on Sep 30, 2023 in |
2-(4-methyl piperazin-1-yl) acetohydrazide was synthesized. The combined practice of IR, 1H NMR, and mass spectrometry established the structure of the synthesized compound. Geometry optimization was performed using DFT at the B3LYP level, employing the basis set 6-31G (d, p). For the optimized structure, surfaces were created to study excited state properties such as electrostatic potential mapped density, highest occupied molecular orbital, lowest unoccupied molecular orbital, ionization energy, and electron affinity. Electric dipole moment, bond length, and angles were computed using the same basis set for the optimized structure. ADMET prediction revealed that the compound possesses the ability to cross the blood-brain barrier and is non-toxic. Further Molecular docking studies with Human Monoamine Oxidase A were carried out to predict the mono-amine inhibitory potential of the compound. The compound revealed better energy scores than the standard. The synthesized compound was evaluated from all aspects concerning essential structural features as well as interaction patterns against selected receptors to be an effective antidepressant. This study would provide an excellent platform to further...
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Posted by admin on Sep 30, 2023 in |
In this work, gel/na-alginate films containing curcumin were made using the straightforward procedure of mixing gel/na-alg solutions, followed by linking with glutaraldehyde solution. Glutaraldehyde was injected into the film solutions made at various proportions (A: G=25:75, 50:50, 75:25 and 10:90), and the resulting film’s mechanical, thermal, and swelling characteristics were evaluated. Gelatin and Sodium alginate were combined in a biocompatible wound dressing material that was effectively used in the biomedical areas. Several biochemical and molecular waterfalls, such as swelling, tissue growth, and the remodeling stage, identify the wound healing procedure. The natural bioactive ingredient curcumin, an anti-inflammatory, antioxidant, and tissue regeneration factor, was introduced in the film. Also, iron oxide nanoparticles are very appealing due to their non-poisonous properties in biomedical applications of biological systems. Composite film loaded with curcumin and iron nanoparticles using biopolymers of gel/na-alg with the help of a crosslinker (glutaraldehyde). The synthesized films are characterized by numerous techniques, including XRD, FTIR, SEM, and Thermo gravimetric analysis (TGA). The chemical studies also carried out were the welling...
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Posted by admin on Sep 30, 2023 in |
Clinical results of various medical treatments using medical devices demonstrate continuous advances, dealing with multiple types of products covering a vast range of applications in the last two decades. Millions of people rely on medical devices to diagnose and manage illnesses. A typical framework for medical device regulations is a whole product life cycle regulatory system that covers product design, production, premarket gatekeeping, and post-market monitoring. Nevertheless, the present regulatory frameworks are being tested by the diversity and innovation of medical devices. This comparative study serves as the basis for the research, which then examines the function of litigation in regulation and ensuring patient safety by placing medical device litigation within the context of the pertinent regulatory...
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Posted by admin on Sep 30, 2023 in |
Background: Thyroid disorders impact the cardiovascular system through direct and indirect mechanisms and are associated with a significantly increased risk of vascular morbidity and mortality. We undertook this study to evaluate the prevalence of thyroid dysfunction in patients with acute coronary syndrome (ACS) and to study the impact of thyroid dysfunction on morbidity and mortality among those patients during 1-year follow-up. Methods: We studied 303 consecutive hospitalized patients between March 2018-February 2021 with ACS to determine clinical and sub-clinical features of thyroid dysfunction and their effect on MACE at 1 year follow-up. They were subjected to full history, clinical examination, routine investigations, and estimation of TSH, FT4 and FT3. Results: The prevalence of thyroid dysfunction in acute coronary syndrome was19%and the majority had subclinical hypothyroidism 34 (11%), followed by overt hypothyroidism 20 (7%). Hyperthyroidism was uncommon (1.3%). There was a significant preponderance of females in the thyroid dysfunction group. The majority 136 (45%) of patients, had STEMI. MACE rates were higher in the thyroid dysfunction group as compared to...
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