Posted by admin on Aug 31, 2023 in |
Wounds are a severe health problem. The development of pharmaceutical dosage forms to ensure patient comfort and safety and optimize treatment effectiveness is of great interest to the pharmaceutical and biomaterials industries. Tridax procumbens (T. procumbens) leaf is a medicinal herb used for treating wounds since ancient times. In this work, a biomaterial film was developed by using PVA with T. procumbens leaf extract via solvent casting method to produce effective wound healing material. According to the hemolytic investigation, films made from T. procumbens leaf extract films were biocompatible. Using L929 mouse fibroblast cells, the cytotoxicity of films was examined using the MTT assay, and the same cell line was also used for a migration assay using the scratch test. The results of the in-vitro wound healing test showed that films containing 12.5 ml T. procumbens dried leaf extract are efficient in reducing the scratch open area, provoking nearly complete closure of the scratches (94%) within 24 hr without cytotoxicity. The 12.5 ml incorporated film demonstrated better wound healing...
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Posted by admin on Aug 31, 2023 in |
Male reproduction is controlled and coordinated by endocrine factors and therefore, even minute changes can able to interfere with the male fertility. Accumulation of data have shown that the humans are exposed to chemicals that can able to interfere with endocrine factors. Interestingly, published reports have shown that the continuous exposure to such chemicals occurs mainly due to their wide usage in a variety of personal care and daily products such as plastics, food, water, fertilizers, textiles, shampoos, toys and pharma drugs etc. In view of ongoing interest in exposure of humans to such agents and compromised male fertility, there is a major concern and attention towards the endocrine disrupting chemicals among the public, endocrinologists, andrologists and scientific community. These chemicals interfere with the endocrine functions via mimicking their structure, blocking the hormone receptor and/or function of genes and proteins that facilitate normal spermatogenesis and testosterone biosynthesis. The present review provides an overview of endocrine disrupting chemicals on male reproductive health with a special focus on thyroid hormone disrupting chemicals....
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Posted by admin on Aug 31, 2023 in |
A wound is a breakthrough of skin; it disrupts the normal functioning of skin. So, the wound healing process is important to repair the skin. It restores the normal function and structure of the skin. There are several phases of the wound healing process: inflammation, re-epithelization, vascularization, and granulation tissue formation and maturation. The wound healing process can be studied using in-vitro and in-vivo methods. There are many in-vivo methods to study the wound healing process. In-vivo method uses laboratory animals for the study. Animals used are mice, rats, rabbits, and pigs. Recently, Zebrafish have been used as a model to study the wound healing process. Zebrafish are used because it has similar wound closure properties as mammalian embryos. The wound healing can be studied by amputating the caudal fin of fish and recording the regeneration of the fin on days 5th, 7th and 9th post-amputation. This study compares various wound healing agents with the market product (neomycin cream). The various wound healing agents used in this study are...
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Posted by admin on Jul 31, 2023 in |
The present study aimed to determine secondary metabolites, in-vitro antioxidant, and antiulcer activities using various solvent-based Muehlenbeckia platyclada extracts. Solvents based phylloclade extraction was used to determine various secondary metabolites such as phenols, flavonoids, terpenoids and tannins and to assess in-vitro antioxidant activities such as DPPH, ABTS.+, superoxide, hydrogen peroxide, nitric oxide, FRAP, Phosphomolybdenum, metal chelating and reducing power activities. Further, in-vitro antiulcer activities such as α-chymotrypsin enzyme, urease enzyme inhibitory activity, H+ K+ ATPase activity and acid neutralization capacity (ANC) were performed, and the resultant was analyzed using response surface methodology (RSM) to develop an adequate functional relationship between a response of interest (ME) with independent variables (Time, HCL consumed and NaOH consumed). A correlation coefficient was made between secondary metabolites and in–vitro antiulcer activities. Methanolic extract (ME) showed higher levels of secondary metabolites, in–vitro antioxidant activities and was subsequently selected to evaluate its antiulcer potential. A significant inhibition for alpha chymotrypsin (88.84%), urease (68.52%), and H+K+ ATPase (91.75%) was compared with respective standards. RSM results of ME...
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Posted by admin on Jul 31, 2023 in |
Background: Geriatrics refers to the population of 60 years and older. The geriatric population is considered a significant consumer of prescription medications. Polypharmacy is a global phenomenon, and on the elderly population, the impact of polypharmacy is substantial. Aging is a multidimensional process, and it is a growing concern. Multiple comorbidities are one of the reasons for polypharmacy. Comorbidity is associated with more complex clinical management and the increase of drug use, and health care costs. In older adults, Drug-drug interactions have potentially life-threatening consequences. Methods: A prospective observational study was carried out for six months in a private corporate hospital in Secunderabad, Hyderabad. The data on patients aged 65 years and above who are hospitalized with comorbid conditions is collected from case sheets. Data includes socio-demographic details, number of medications, name of medications and comorbidities. Results: A total of 300 patients were included in the study. Polypharmacy was seen in 217 (72%) prescriptions and non-polypharmacy was seen in 83(27%) prescriptions. A total of 168 comorbid conditions were found...
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