Posted by admin on Jul 31, 2023 in |
Probiotics are active microbes found in fermented milk products that support the host’s health when taken in sufficient amounts. Probiotics are typically made from strains such as Lactobacilli and Bifidobacteria isolated from the human intestine, breast milk, and conventional fermented milk products. The choice of the optimal probiotic microorganisms is a crucial initial step. Probiotics are utilized to treat allergies, intestinal, liver and numerous metabolic illnesses, and acute and antibiotic-associated diarrhea, which they prevent and treat clinically. Probiotics have the power to control intestinal permeability, maintain a healthy balance of the host’s microbiota, enhance the gut immune system functioning and balances the activation of pro- and anti-inflammatory cytokines. Providing consumers with probiotic formulations that provide the required dose at the end of their shelf life is a major challenge for pharmaceutical companies. Probiotic Lactic acid bacteria and Bifidobacteria have historically been added to fermented dairy products, which are refrigerated and have a short shelf life. Probiotics can now be added to a variety of ‘dry’ food matrices, such as...
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Posted by admin on Jul 31, 2023 in |
To increase patient compliance, safety, and effectiveness, the need for the design and development of a new dosage form has arisen. Novel film technology like buccal film meets all these needs. The buccal film is inserted into the mouth and the medicine is then absorbed via the buccal mucosa. Compared to alternative buccal drug delivery systems such as wafers, lozenges, microparticles, gel and tablets, buccal film is a more appealing and acceptable dosage form due to its small size, dose and ease of administration. Because it avoids first-pass digestion, buccal film is a very efficient dose form that significantly boosts bioavailability. It is more practical than other forms of dosing because it sticks well to the buccal mucosa of the mouth. Not ingesting the medicine is necessary; it is non-irritating and cost-efficient; other benefits include its sleek design, ease of use and biodegradability. Therefore, this dose type is preferred by both elderly and young patients. This review focuses on buccoadhesive drug delivery methods, which are reliant on adhering to...
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Posted by admin on Jul 31, 2023 in |
The eye is a sensitive organ, and the administration of drugs into the ocular cavity is a tedious task. Ocular insert is the prominent technique to overcome problems associated with conventional dosage forms like repeated administration, drug drainage via lacrimal fluids drainage, formation of crystalline deposits on the cornea, pH instability, pulsed dosing of drugs, etc. This review focuses on developing a novel technique to treat ailments associated with the eye cavity. The major complications associated with the drug’s delivery into the eye are rapid pre-corneal drug loss due to nasolacrimal drainage, tear flow, and dilution of the drug leading to poor bioavailability, inadequate residence time, etc. Ocular inserts are thin films meant to be placed in a cul-de-sac, providing prolonged release without irritating the eyes. They are mostly made of polymers that encloses drug within them, which aids in the sustained release of the drug. Newer ocular drug delivery systems are being surveyed, such as Collagen shields, Biodegradable polymers, Inserts, Outfit, Minidisc`s, NODS, etc., and are formulated to...
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Posted by admin on Jul 31, 2023 in |
A number of the population in developing countries use herbs and herbal products to treat various diseases including malaria. However, most of them have not been evaluated for their efficacy and toxicity and their use is not standardized in some instances. Poly-herbal extracts may yield better treatment outcomes compared to extracts from a single plant due to the combined effects of bioactive compounds from the multiple sources. Cassia obtusifolia and Hyptis suaveolens are two plants commonly used in herbal preparations for treating malaria in Ghana. This study was to investigate Plasmodium falciparum asexual growth inhibitory activities of the individual and combined leaf extracts of the two plants. Leaves of the C. obtusifolia and H. suaveolens were extracted separately with methanol, ethanol and water. The six extracts, as well as in combination were evaluated in a dose-dependent manner for their antiplasmodial activities against the chloroquine-sensitive Plasmodium falciparum 3D7. Aqueous extract of C. obtusifolia, including the mixture of the two plants were highly active with mean IC50 less than 4.0 µg/mL....
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Posted by admin on Jul 31, 2023 in |
Objective: This work aims to evaluate in in-vivo the Antiarthritic and Anti-inflammatory activities and in-vitro antioxidant activity on Poly Herbal Formulation in rats. Method: Arthritis is a disorder of change in joint architecture and ligament degeneration. In this polyherbal formulation, medicinal plants were Zingiber officinale (33.931mg), Piper nigrum (33.931), Piper longum (33.931mg), Spergularia daemia (30 mg), Delonix elates (30 mg), Acalypha indica (30 mg), and Carum copticum (101.79 mg), which are well-known plants throughout India. They are commonly used to treat various disorders like cancer, diabetes, arthritis, rheumatoid arthritis, atherosclerosis, and chronic inflammatory disorders. The quality of finished products was evaluated as per the World Health Organization’s guidelines for the quality control of herbal materials. Arthritis and inflammation were induced in both male and female Sprague-Dawley rats. Freund’s complete adjuvant (FCA) is used for antiarthritic effect. Carrageenan-induced is used for the anti-inflammatory effect of polyherbal formulation (Rheumatigo) was studied at doses of 250 and 500 mg/kg and the effects were compared with prednisolone (10 mg/kg) and diclofenac (20 mg/kg)....
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