Posted by admin on Jul 31, 2023 in |
Moxifloxacin (MOX) is a second-line treatment for drug-susceptible and multidrug-resistant tuberculosis (MDR TB). MOX has poor patient compliance due to taste and odour concerns, particularly in the pediatric population. MOX taste-masked chewable tablets were developed by direct compression method using mannitol, aspartame, and sucralose as sweetening agents and lemon and peppermint flavor as flavoring agents. The lubricated granules were evaluated for flow properties, and compressed tablets were evaluated for hardness, friability, content uniformity, weight variation, DT and in-vitro drug release. FTIR, DSC, and XRD analysis were performed to detect any possible drug excipient compatibility issues and the nature of the drug molecule in the formulation. F6 formulation granules showed excellent flow properties, and batches manufactured with these granules showed physicochemical properties within acceptable limits. Complete drug release was observed within 8 minutes from the F6 formulation. FTIR and DSC studies demonstrated no drug excipient compatibility issues. According to XRD, the MOX in the final formulation was present in crystalline form. The dispersible MOX pills would be a superior alternative...
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Posted by admin on Jul 31, 2023 in |
Nowadays, the use of herbal drugs is tremendously increased due to the lesser number of side effects when compared to pure form of drugs. Herbal medicine is a complex compound with multiple synergistic mechanisms of action which modulate pathophysiological functions. Even though few herbs exhibit toxicity, they possess many therapeutic values and curative principles; one such herb is calotropis. It exists in three species that produce pharmacological effects: cardiovascular, anti-cancer, antimicrobial, anticonvulsant, and smooth muscle relaxant. In this research, 24 chemical constituents of all calotropis species were selected. The molecular properties, bioactivity scores, ADMET profile of 24 calotropis species chemical constituents were predicted using computational tools, including mol inspiration, Pre ADMET, and structures drawn using chem sketch. The results drawn from the study were compounds C8[Syriogenin] and C16[urosolic acid] exhibited good oral bioavailability, bioactivity scores, intestinal absorption, renal absorption, decreased metabolism rate by inhibiting CYP3A4 and less toxic by Ames...
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Posted by admin on Jul 31, 2023 in |
The Bionanofibers drug delivery systems can reduce toxicity, improve therapeutic efficacy and increase patient compliance by delivering drugs at a controlled rate to the site of action. The major aim in designing nanostructures as delivery systems is to deliver pharmacologically active molecules with accurate doses at targeted sites. The present research work developed Bionanofibers as a carrier for drug delivery. Because of the very small nanoscale diameter and high surface area, significantly higher drug content can be loaded in a very small volume. Bionanofibers were manufactured from Macitentan drug using PVP and Soybean PC by electrospinning. The obtained bionanofibers were characterized based on morphology, entrapment efficiency, and drug release behavior. FE-SEM images showed that the length of obtained bionanofibers is about 580nm to 1250nm in diameter. FTIR analysis shows no significant interaction between the drug and the polymer. The in-vitro release study demonstrated that there is a controlled release pattern of drugs from...
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Posted by admin on Jul 31, 2023 in |
Proton Pump Inhibitors (PPIs) are widely used acid suppression medications for many conditions. PPIs class includes many drugs, such as omeprazole, lansoprazole, pantoprazole and esomeprazole, available orally in a tablet/capsule form. PPI’s products have reasonably high prices with quality differences that most healthcare providers must know. Therefore, this study aimed to compare the quality of PPIs for brand and generics in the Saudi market. Gastric ulcers result from an imbalance involving gastric protection and aggressive factors. Gastric protection depends on several factors, such as the release of prostaglandin E2 (PGE2), bicarbonate secretion, gastric mucus production, and gastric mucosal blood flow regulation. Factors leading to gastric offensives are the hypersecretion of H.C.L. or pepsin. Ethanol is well known to induce gastric ulcers via multi-factorial mechanisms such as the impairment of gastric defensive factors like mucus dissolution or by increasing offensive factors such as acid secretion or gastrin release. Our study reveals that the gastroprotective effect of PPIs marketed in Saudi Arabia has significantly protected the gastric mucosa against ethanol...
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Posted by admin on Jul 31, 2023 in |
Contrast-induced nephropathy (CIN) is a frequent cause of hospital-acquired acute kidney injury (AKI) and is associated with adverse clinical outcome. It occurs often among patients with multiple comorbidities and compromised renal function. This study is aimed to determine the prevalence of the risk factors associated with contrast-induced nephropathy in patients undergoing various percutaneous coronary interventions (PCI). A prospective observational cross-sectional study was conducted in a tertiary care hospital for 12 months. Patients undergoing PCI were recruited in accordance with the eligibility criteria. The baseline characteristics as well as laboratory and cath-lab procedure data, were obtained from their case files. The prevalence of risk factors among the patients was assessed using the Mehran score and the association of risk factors with CIN was analysed using binary logistic regression. CIN was prevalent in 30 (15%) out of 200 recruited patients. The prevalence of risk factors among the recruited patients was 8.5% aged > 75 yrs, 11% hypotensive, 9% requiring an intra-aortic balloon pump, 44% anaemic, 36% diabetic, and 4.5% having serum...
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