Posted by admin on Jul 31, 2023 in |
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while controlling the remaining risks and uncertainties. This review article aspects the highlights of analytical procedure validation and development (ICH Q2 (R2) and ICH Q14). Both the guidelines have been produced by one panel of subject-matter experts and are currently accomplishing the crucial ICH landmark of Step 2 publishing for public comment. The ICH brings both regulatory agencies and pharmaceutical industries to discuss the scientific and technical aspects of drug approval. Since its beginning in 1990, ICH has regularly progressed to meet the international challenge of drug development. ICH’s purpose is to promote better peace worldwide to ensure that secure, useful, and elevated medicines are being developed and registered in the most resource-efficient manner possible. The...
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Posted by admin on Jul 31, 2023 in |
Immunity plays an important role in the protection of the human body and provides several beneficial effects on many infectious diseases and also immunity produces hyperactivity which also causes some problems for the human body, so we want to discuss a summarized knowledge about immunity and their important, advantages, disadvantages and effects on the human body. The present review focuses on various therapeutic effects through different disease conditions, such as autoimmune disorders, infectious diseases, and organ transplants. Thus the immune system and immunity are promising parts for the protection of the human body, which has wide importance in beneficial and another impact in therefore much research can be inspired in this...
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Posted by admin on Jul 31, 2023 in |
One of the main causes of mortality around the globe is cancer. Cell division routes increase as cancer progresses, but planned cell death decreases. As a result, cancer is characterized by a variety of these failing systems. The present study used an in-silico approach to examine the ability of sesquiterpene lactones to inhibit the anti-apoptotic proteins Bcl-2 and Bcl-xl. Numerous Bcl-2 inhibitors are undergoing clinical studies. Using PyRx AutodockVina, the phytocompounds were further examined for their in-silico docking interactions. It is interesting to develop novel Bcl-2 inhibitors from phytocompounds such as Arctigenin, Arteminolide C, Gaillardin, Helenalin, and Ixerin D, which have binding affinity scores similar to obatoclax. Potential binding mechanisms within the receptor’s active sites were explored using molecular docking studies of all active substances into the binding sites of Bcl-2 and Bcl-xl, and the physiochemical properties of the phytocompounds were predicted according to Lipinski’s rule of...
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Posted by admin on Jul 31, 2023 in |
Nowadays, some medicinal plants have been reported to be useful in diabetes worldwide and have been used analytically as antidiabetic medicaments. Bundelkhand is a historic zone of central India. This region is known as the land of fighters, sacrifice, and love. It’s spread in the range of Uttar Pradesh and Madhya Pradesh state. It includes seven sections of Uttar Pradesh and six sections of Madhya Pradesh. Despite the presence of known antidiabetic drugs in the pharmaceutical request, diabetes, and related complications continued to be major medical problems. Antihyperglycemic effects of these plants are attributed to their capability to restore the function of pancreatic tissues by causing an increase in insulin production or inhibiting the intestinal immersion of glucose to facilitate metabolites in insulin-dependent processes. Diabetes mellitus (DM), also known as insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM), is a common and serious metabolic condition that affects people each over the world. Traditional herbal plants have been employed to treat diabetes mellitus all throughout the world. Several herbs...
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Posted by admin on Jul 31, 2023 in |
Thunbergia grandiflora Roxb. (Mizo local name- Vakohrui or Zawngafian), commonly known as Bengal clockvine, is a long-lived, dicotyledonous plant traditionally used in the state of Mizoram, India for the treatment of cancer, diabetes, eye diseases, cuts and wounds etc. This study aimed to conduct in-vitro, in-vivo anti-inflammatory studies and HPTLC fingerprinting and quantifying the bioactive compounds from Thunbergia grandiflora Roxb. The IC50 value of Egg albumin and BSA denaturation studies was found to be 423.59 µg/ml & 400.76 µg/ml respectively. The results showed that methanolic leaf extract of the plant 200mg/kg b.w. and 400mg/kg b.w. considerably reduced carrageenan-induced paw edema, and their effects were comparable to the standard diclofenac sodium. HPTLC analysis showed the presence of β -Sitosterol in the methanolic extract and the amount of β -sitosterol was found to be 22ng/µl. The identity of the bands of β -Sitosterol in the samples was confirmed by overlapping their UV absorption spectrum with that of the standards. The results for anti-inflammatory studies showed marked anti-inflammatory activity, which was found...
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