Posted by admin on Jul 31, 2023 in |
Chickpeas (Phaseolus vulgaris L.) contain various health-promoting bioactive components. Examples: Alkaloids, anthocyanins, catechins, carbohydrates, fibre, flavonoids, phytic acid, quercetin, saponins, steroids, tannins and terpenoids are plant components. Nevertheless, little is known about how these bioactive chemicals function in progressive situations. These results suggest that P. vulgaris seeds could cure metabolic diseases, including diabetes and obesity. This research offers enormous potential for nutraceuticals. Further research is needed to confirm and extend previous findings. Phaseolus vulgaris seeds are also needed in complementary and alternative medicine and pharmaceutical companies. Plant-derived drugs like quinine, artemisinin, digoxin, atropine, strychnine and reserpine have been demonstrated to treat many disorders. Due to their low cost, effectiveness, and safety, traditional medicine and herbal medicines provide the most primary medical care in the world’s poorest countries. Any plant component can produce secondary metabolites or bioactive compounds. Glycosides, tannins, alkaloids, flavonoids, steroids, and triterpenoids have several health benefits. After testing, these plant chemicals are antibacterial, antioxidant, anticancer, and...
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Posted by admin on Jul 31, 2023 in |
Evaluation of drug utilization patterns and cost analysis (direct and indirect) at the dermatology department help to implement guidelines/policy regarding rational prescription and reduce the cost burden on the health care system. The 250 patients’ prescriptions attending the dermatology outpatient department were analyzed using WHO core drug use indicators. Prescribed drugs were classified according to ATC/DDD classification system, the PDD/DDD ratio of drugs was calculated, and direct and indirect costs per encounter were done. The average drug per prescription was 3.3±1, the percentage of drugs prescribed by generic name was 95.52%, the percentage of utilization of scheduled drugs from the National List of Essential Medicines (NLEM) (2022) was 98.79%, the percentage of scheduled drugs from the WHO essential list (2019) was 46.73%. Patient’s care indicators where average consulting time was 7min±1min, average dispensing time was 7min±2min, percentage of drug dispensed was 95.04%, and patient’s knowledge about correct dosage is 10%. Antifungal (26.66%) class of drugs were prescribed maximum followed by antihistaminic (25.42%) in participants. Among prescribed drugs, 41.66% of...
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Posted by admin on Jul 31, 2023 in |
Sudden cardiac death (SCD) is the most common cause of mortality among cardiovascular etiologies. Drug-induced Long-QT syndrome (diLQTS) is a prominent occurrence in Intensive Care Units (ICUs), often progressing to Torsades de Pointes (TdP), resulting in SCD. A prospective observational cross-sectional study was conducted to determine the prevalence of risk factors for diLQTS and to identify patients at risk for it in ICUs using the Tisdale score. Patients were recruited based on the selection criteria, and data on their demographics, laboratory and ECG assessments and administered medications were obtained from their case files. The prevalence of risk factors was calculated and the risk for diLQTS among the patients was assessed using the Tisdale score. Among 150 patients recruited, 51% and 49% were male and female, respectively, mostly aged >65 years (38%). QTc-prolongation was prevalent in 46% of patients. The prevalence of risk factors among the patients was: 35.33% aged ≥68 years, 40% females, 42% hypokalemic, 14% with acute MI, 28% with heart failure, 4% with sepsis, 24.66% prescribed with...
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Posted by admin on Jul 31, 2023 in |
A new simple, accurate, rapid, selective and robust high-pressure liquid chromatography (HPLC) method was developed and validated for simultaneous estimating itraconazole and Terbinafine in bulk and marketed formulation. Acetonitrile and double distilled water was used as a mobile phase for chromatographic separation and estimation on C18 Targetsil column with dimensions 250×4.6 mm in the ratio of 90:10 v/v at flow rate of 1.0 ml/min. The detection was carried out with U.V. Visible detector (Shimadzu SPD10A) at 225 nm. The retention time for itraconazole (6.1 min) and for Terbinafine (9.8min) was obtained. The linearity range for itraconazole and Terbinafine was 1-8μg/ml with a coefficient of linear regression 0.996 and 0.992, respectively. The method was validated in accordance with the requirements of the International Conference on Harmonization (ICHQ2 (R1) 2005) guidelines for accuracy, precision, LOD & LOQ, linearity and...
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Posted by admin on Jun 30, 2023 in |
Bazedoxifene acetate represents a promising new treatment for osteoporosis. LC-MS SIR (Selective ion recording) mode, the shortest runtime method, was developed and validated for the trace level quantification of two potential genotoxic impurities, i.e., Impurity-A (1 – Benzyloxy – 4 – nitrobenzene) and Impurity – B (4-benzyloxy-2-bromopropiophenone) in Bazedoxifene acetate drug substance. The concentration limits of both genotoxic impurities were calculated a limit of 75ppm based on the concept of TTC (threshold of toxicological concern) and MDD (maximum daily dosage, which is 20mg/day for Bazedoxifene acetate drug substance). The mobile phase used for the method was 10mM Ammonium acetate and acetonitrile in the ratio of (30:70) v/v with isocratic mode elution at flow rate 0.6mL/min, stationary phase used as X-Bridge C18 (50×4.6) mm, 3.5µm and run time was 5 minutes. The Impurities were quantified by using MS detector SIR mode (Selective ion recording) at m/z of 230.12 and 319.01 for Impurity-A and Impurity-B, respectively. The detection limit (DL) was 1.4 ppm for both Impurity-A and Impurity-B. The quantification limit (QL)...
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