Posted by admin on Jun 30, 2023 in |
Even though the malady of dementia has existed for thousands of years, the correlated neurodegenerative alterations taking place in certain regions of the human brain were detected in recent times. Today, we are aware that dementia is a primary manifestation of Alzheimer’s disease (AD). In 1907, Alöis Alzheimer described the symptoms of a 51-year-old woman, Auguste Deter, who was under his observation at the state Asylum in Frankfurt (Germany). Alois Alzheimer noticed the existence of unusual accumulations in the brain (described as amyloid plaques today) and a massive loss of neurons while examining the brain of his first patient that suffered from memory failure, bizarre behavior and abnormal personality before death. With the enhanced lifespan, direct and indirect health expenditures of patients suffering from AD have increased exponentially. There is neither an appropriate experimental model for testing the memory of animals akin to human memory nor any cure for AD. It is important to investigate the past events resulting in AD to comprehend the present scenario and gain insight...
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Posted by admin on Jun 30, 2023 in |
Tinospora sinensis (Lour.) Merr. belongs to the family Menispermaceae is, an important medicinal plant. Ayurveda, an Indian medicinal system, strongly advocates use of T. sinensis as a rejuvenator and several other therapeutic activities. The study’s objectives were to assess the effect of the extraction procedure and different solvent systems on antioxidant, total phenol content and total flavonoid content of T. sinensis. Two conventional extraction methods, cold maceration and Soxhlet extraction, were used to extract four parts of the plant and six different solvent systems viz., petroleum ether, ethyl acetate, chloroform, acetone, ethanol and methanol were used according to their polarity gradient. The total phenolic content was determined using the Folin-Ciocalteau method, and total flavonoid content was determined by aluminium chloride. The antioxidant activity was performed following two in-vitro technique assays, DPPH and ABTS radical scavenging assay. All the extracts of six solvents have potent antioxidant activity and methanol and ethanol extracts showed higher levels. The assimilatory root, stem, root and leaf of T. sinensis possess total phenol and flavonoid...
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Posted by admin on Jun 30, 2023 in |
In this paper, a Quality by Design-guided and Risk Assessment (RA)-based study was performed to determine the Critical Material Attributes and the Critical Process Parameters. Direct compression method was applied for the preparation of ODT containing Brivaracetam using 22 factorial designs with the quantity of drug, pharmabust 500 and crosspovidone as independent variables. Pharmabust 500 and crosspovidone were used as Superdisintegrants. Design Expert 11.0 described adequately impact of selected variables as dependent (pharmabust 500 and crosspovidone) at various levels for response under study (DT and Drug Release at 2 min). Further Optimization of formulation was done using Factorial design (2 factor 2 levels) and established control strategy and design space of the formulation. Design validation was done and final optimized batch P7 was chosen from the design space. The final formulation P7 was tested for Accelerated Stability Studies for 1 month and found stable. As per the results obtained from the experiments, it can be concluded that QbD is an effective and efficient approach for developing quality into ODT...
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Posted by admin on Jun 30, 2023 in |
Background: Imidazole-5-one scaffold has been predicted in the important synthetic drug analogs, which gave valuable information for treatment and high binding affinity to the multiple receptors helpful drug development. Objective: To synthesize and evaluate the anthelmintic, anticancer, and Insilco docking studies of pyrazole contain novel Indole derivatives (4a-4h). Methods: In the present work, we intended to synthesize pyrazole containing novel Indole derivatives (4a-4h) by a conventional method. Results: All the newly synthesized molecules (4a-4h) were characterized by FTIR, 1HNMR, and Mass spectral analysis. The compounds 4c and 4f showed high anthelmintic activity compared with Albendazole as a standard and the compounds 4b, 4e, 4f, and 4g exhibited good anticancer activity against MCF-7 cell line. In molecular docking research, dock rankings of all the synthesized derivatives ranged from -5.972 (compound 4h) to -3.127 (compound 4d). Conclusion: The literature reveals that Imidazole-5-one derivatives have diverse biological activities and a cytotoxic potential to be explored for newer therapeutic...
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Posted by admin on Jun 30, 2023 in |
Rheumatoid Arthritis (RA) is an autoimmune inflammatory illness characterized by persistent synovial inflammation. It’s the most common form of arthritis that causes inflammatory changes in the tissue of joints, destroys cartilage and bones, and affects the quality of life. This diverse disease has a wide range of disease progression and treatment responses. Because the precise origin of rheumatoid arthritis is still unknown, no medicine can ensure a full recovery. Biomarkers guide the clinical and pharmacological management of rheumatoid arthritis at all phases. This is because they can help in the monitoring of disease activity and progression, the prediction of illness beginning in at-risk patients, and the provision of predictive data. American College of Rheumatology (ACR) emphasized on initial investigation of clinical findings based on the physical data for the diagnosis of RA. Although Rheumatoid factor and anti-citrullinated protein antibodies are the two biomarkers that can be used to determine who is at risk for the condition and who has pre-clinical rheumatoid arthritis before symptoms develop, there are involvements of...
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