Posted by admin on Jun 30, 2023 in |
Marine microorganisms are a valuable source of novel enzymes with ideal characteristics because of the halophilic nature of marine bacteria. The present study aims to isolate, screen, and identify the marine bacterial strains from marine sediment samples that produce an enzyme urease with clinical and industrial applications. Marine sediment samples were collected and cultured on zobell marine agar medium. After incubation seven bacterial strains were isolated from the culture. From this, five isolates were showed urease activity on the urea agar base medium. Morphological and biochemical test of urease-producing organisms was done. Urease-producing bacterial strains (UR S7B) were selected on the basis of their urease test. The selected strain UR S7B was further sequenced for identification. The phylogenetic characterization and 16S rRNA of the strain UR S7B revealed that bacterial cultures belong to Bacillus sp. The morphological studies indicated that the isolate was Gram -ve, rod-shaped and motile organism. The present study concludes that marine bacteria can be a urease source with important...
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Posted by admin on Jun 30, 2023 in |
Multifunctional, versatile materials with multiple dendrimer branches have myriad binding sites and are in high demand for their drug binding, loading potential, and coatings. Dendrimers are among the latest generations of nano-systems that are potential drug carriers. Dendrimer chemistry is one of modern chemistry’s most captivating and fastest-growing areas. Dendrimer research has grown exponentially in recent decades, from synthesis to application. The distinctive structural features of dendrimers include their nanoscopic size, multi-functionalized surface, strong branching, cavernous interior, etc., which makes dendrimers themselves ideal drug carriers. Dendrimer provides a unique platform for drug attachment that can bind and release drugs through several mechanisms. Developing new smart materials and tracking their structural potential have been focused on curing disease. Other applications, such as catalyzing biomolecules like proteins and selective API pharmaceuticals of toxic metals, dyes, and pesticides, have been thrust research areas in materials and pharmaceutical sciences. In recent years Dendrimers have received significant consideration as drug delivery carriers. As a drug delivery agent, Dendrimer is a promising, safe, and selective...
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Posted by admin on Jun 30, 2023 in |
A cross-sectional study was conducted among 140 study subjects in an urban residential area of East Delhi selected by simple random sampling method to assess the prevalence of self-medication for Covid-19 and associated socio-demographic and economic factors. Data were collected by interviewing the study subjects using a pre-tested semi-structured interview schedule. The Mean+SD age of the study subjects was 41.89+13.54 years (range: 20 to 75 years); 77 (55.0%) were males, and 75.7% were graduates and above. There were 86 with a Covid-19 positivity history. The prevalence of self-medication among them was 33.7% (95% CI: 23.9%, 44.7%), least in 30-39 years (5.9%, 95% CI: 0.1%, 28.7%), maximum in 40-49 years (44.4%, 95% CI: 21.5%, 69.2%) (p=0.101), higher in females (38.1%, 95% CI: 23.6%, 54.4%) than males (29.5%, 95% CI: 16.7%, 45.2%) (p=0.402), socioeconomic class III (52.4%, 95% CI: 29.8%, 74.3%) and least among class I (20.0%, 95% CI: 9.6%, 34.6%) (p=0.017). Self-medication was not associated with education level, working status and marital status. Prevalence of self-medication was high during the...
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Posted by admin on Jun 30, 2023 in |
Andrographis paniculata Nees is a valuable medicinal herb of Acanthaceae family, is used for centuries to treat several diseases including viral hepatitis, cirrhosis, malaria and diabetes. This medicinal plant has hepato-protective, immunological, anti-bacterial, anti-inflammatory, anti-oxidant and antithrombotic qualities. It has many important bioactive compounds such as diterpenoids, flavonoids and polyphenols. Diterpenoids, including andrographolide, neoandro-grapholide and dehydroandrographolide are the main determinants of Andrographis paniculata quality. The most common and abundant form is andrographolide. Numerous human ailments are treated and prevented by it. Due to its various therapeutic applications, it is widely cultivated in many parts of the world and its relevance as a medicinal plant is constantly increasing. A comprehensive bibliographic search was conducted using offline and Online Databases. The current review aims to offer an updated and thorough analysis of the chemical components, explore their pharmacological potential and lay the basis for further...
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Posted by admin on Jun 30, 2023 in |
There are a variety of causes of death, but one of the most common is a suicide, which has an annual global average rate of roughly 13 per 1000000 people. Men commit suicide at a higher rate than women. Suicide rates were reduced by prescribing higher doses of current antidepressants; however, multiple ecological, cohort, case-control, and controlled clinical trials in patients with acute affective disorder discovered that the risk of suicide ideation is higher in younger patients. As a result, this remains a matter of debate whether antidepressants enhance suicidal ideation in younger patients with acute affective illness. This review outlines the neuroscience of suicide and look into the link between antidepressants and...
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