Posted by admin on May 31, 2023 in |
In Indian and Chinese medicine, the herb Bacopa monnieri, (Neer Brahmi) has long been used to treat a wide range of illnesses. Brahmi offers a wide range of pharmacological advantages, including improving memory in the treatment of schizophrenia and Alzheimer’s disease. The effectiveness of Brahmi in scavenging and illuminating as well as comprehensive analyses based on its pharmacological effects on the thyroid are the focus of the current review. Up until April 2022, PubMed, Scopus, and Google Scholar were searched to find information about the effectiveness of Bacopa monnieri in treating thyroid disorders. The review’s conclusions provide an overview of the information gathered over the preceding five years from various platforms and database libraries. For all calculated data, a number of outcomes were combined into verified constructs to enable direct comparisons. Four papers satisfied the criteria for inclusion in this review. This extensive study provided a summary of Bacopa monnieri’s effectiveness in scavenging free radicals and deciphering thyroid disorders. It’s time to move on to other prevalent problems because...
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Posted by admin on May 31, 2023 in |
This study aimed at identifying promising breast cancer inhibitors through in-vitro and in-silico studies. Ocimum basilicum. L is a traditional herb used for varied ailments. The present study is designed to evaluate the anti-carcinogenic potency of Palustric acid and Andrographolide against the MCF-7 cell line by in-vitro analysis. Further in-silico examination was performed to detect and formulate Receptor-ligand complex of estrogen using molecular docking technique. In-vitro study was conducted using MTT assay and microscopic examinations to determine the cell viability and morphological changes in MCF-7 cells. In-silico, scrutiny was performed using virtual screening, Docking, ADME, and molecular dynamic simulation to evaluate the stability of the compounds. Palustric acid and Andrographolide against the MCF-7 cell line by in-vitro analysis. Further in-silico examination was performed and showed an outstanding anti-cancer potential, with dose- and time-dependent patterns in MTT assay and through the fluctuating organization of MCF-7 cells. In-silico analysis showed that the selected lead compound-complex exhibited good stability and was a highly potent inhibitor against the target breast cancer receptor. This...
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Posted by admin on May 31, 2023 in |
In the present study, biosurfactant-producing microorganisms such as KM1 (Bacillus licheniformis – Kasemedu 1), KM2 (Bacillus subtilis – Kasemedu 2), ER1 (Pseudomonas aeruginosa – Ennore site 1), ER1B (Pseudomonas mendocina – Ennore site 1) and ER9 (Streptococcus lactis – Ennore site 2) were subjected to optimization studies. The optimization study was carried out using various carbon, nitrogen sources, pH, temperature, hydrocarbons, and trace elements. The effect of dry cell biomass, biosurfactant production, emulsification activity, and surface tension were studied. Among the five isolates, KM2 and ER1 grew well in sucrose at 1% concentration. Production and activity of the biosurfactant were found to a maximum at pH 7.0, and an additional increase in pH during bacterial growth does not affect the surfactant activity till pH 8.5±0.2; however, a decrease in pH showed a significant effect on the surfactant activity. The optimum temperature was identified as 37°C for all the isolates and below and above this temperature markedly affects the biosurfactant production and activity. Observations on reduction in surfactant activity with...
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Posted by admin on May 31, 2023 in |
The relevance of traditional medicines and their folkloric applications for the well-being of humanity have been highlighted in the current study. To generate the polyherbal extract for the in-vitro assessment of anticancer activity, the researcher has investigated the standardization criteria for the individual plant drug and extract obtained from these herbs. According to the literature and earlier studies, all four of the herbs utilized to create polyherbal extract have the potential to cure a variety of malignancies in addition to liver carcinoma. The physiochemical and pharmacological value of each medicinal herb and the polyherbal extract of these four plant drugs (Vinca, Jackfruit, Lawsonia, and Ashwagandha) are revealed in the same research findings. Based on the results of phytochemical testing, it is evident that the majority of these phytochemicals employed include the alkaloids and steroids in n-hexane extract, which also suggests the possible anticancer effects of each drug separately. The MTT dye assay assessed the polyherbal extract’s cytotoxic impact on the Huh7 cell line. The polyherbal extract’s anticancer results are...
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Posted by admin on May 31, 2023 in |
Medicinal plants are a huge treasure for mankind and a source of remedy for all illnesses as they are storehouses of bio-actives. The therapeutic efficiency of formulations and medicines depends on using standardized plant extracts, as The World Health Organization emphasized. The present documentation on the medicinal plant Pisonia grandis covers its pharmacological, phytochemical, biological standardization studies and the quantification protocols for the bioactive pinitol and bioactive allantoin earlier reported from this plant. This documentation sheet will aid as a reference for formulating Pisonia grandis-based herbal medicinal...
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