Posted by admin on Nov 30, 2023 in |
The present study is reported the antioxidant activity of oxazole derivatives. Oxazole are five-member heterocyclic ring containing nitrogen and oxygen as a hetero atom. Due to binding with a wide spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions, oxazole-based molecules are becoming a kind of significant heterocyclic nucleus, which have received attention from researchers globally, leading them to synthesize diverse oxazole derivatives. Oxazole have been reported to possess diverse biological activities like antimicrobial, antiviral, anti-inflammatory and anticancer activity. In this research work some heterocyclic like 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one with potent derivatives for 100 ug/ml are 4-(4-methylbenzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-7), 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl)oxazol-5(4H)-one (PA-13) and are 4-(5-Oxo)-2- (pyrazin-2-yl) 4(5H)-ylidene) methyl) benzonitrile (PA-15) and for 200 ug/ml 4-(4-fluoro benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-4), 4-(4-hydroxy-3-methoxy benzylidene)-2- (pyrazin-2-yl) oxazol-5 (4H)-one (PA-8) and 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-13) shows promising anti-oxidant activities. The method mainly used as hydrogen peroxide radical scavenging activity. Antioxidant scavenging effect of synthesized derivatives also compared with standard Ascorbic...
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Posted by admin on Nov 30, 2023 in |
The current study aims to develop and evaluate herbal mouthwash and ascertain its effectiveness against microbes. Conventionally herbal mouthwashes are used as a disinfectant to lessen the presence of microbes in the oral cavity. Herbal mouthwashes act as a preventative agent for bleeding gums, decoloring teeth, and killing off bad breath germs. The herbal mouthwashes also have inherent benefits of plaque control and inflammation. The formulated mouthwash was prepared using herbs and the extract was extracted by hot water extraction method. Additional analysis of the Phyto ingredients was done where the flavonoid content and phenolic content was estimated as 41.71µg/ml and 76.25µg/ml, respectively and the in-vitro antibacterial assay was performed against Streptococcus mutans and Streptococcus salivarius and the zone of inhibition was calculated as 18mm and 22 mm at the highest concentration. The results indicated that the mouthwash exhibits effective antibacterial qualities. These solutions can be used for various things, including reducing the growth of germs in the oral cavity and for their analgesic, anti-inflammatory, or antifungal...
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Posted by admin on Nov 30, 2023 in |
Introduction: Cervical spondylosis is a degenerative spine disorder commonly affecting the vertebrae and intervertebral discs in the cervical region. Most people commonly present with the complaint of neck pain at least once in their lifetime. It is, therefore, important to ascertain the cause responsible for it. Homoeopathy has a great scope in relieving the pain caused due to spondylosis, thereby preventing the further progress of the disease pathology caused by this disorder. This case was undertaken to assess the efficacy of homoeopathic medicine for managing cervical spondylosis. Case Summary: A 58 years old female complained of neck pain, tingling and numbness with burning over right upper limb for the past 15-20 days. She also complained of headache on and off. No history of vertigo, giddiness was noted. No history of any other major illness was found during the interview. On detailed analysis and repertorization of the case, the homoeopathic medicine Rhus toxicodendron was given. This case was successfully treated with the selected homoeopathic medicine and auxiliary measures, and further...
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Posted by admin on Nov 30, 2023 in |
Breast cancer refers to cancer emerging from breast tissue, commonly from the lobules that supply the ducts with milk or from the inner linings of milk ducts. Due to the mutation of DNA or RNA from the normal cells and abnormal genes when inherited, cancer cells are evolved. LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. This prompted us to design newer LMTK3 inhibitors as efficient therapeutic drugs for the treatment of Breast cancer. Based on the common pharmacophoric features for the inhibition of LMTK3, a series of leads were designed using computational methods. A virtual library consisting of newly designed 100 molecules as LMTK3 inhibitors was constructed. Based on these facts, a scaffold library has been created with 100 newly designed ligands containing aromatic rings, Imidazole, pyrrole, indole, benzimidazole, morpholine, benzothiazole, pyrazine, quinoxaline, pyridine, indolinone, oxazole, quinolizine as LMTK3 inhibitors. The binding...
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Posted by admin on Nov 30, 2023 in |
Immunotherapy is among cancer immunology’s fastest and most furious treatment strategies. The therapeutic perspective of checkpoint inhibitors is represented through the Food and Drug Administration (FDA) approvals for their implementation in various malignancies. Efforts to improve results with immunotherapeutic agents have led to the design of advanced treatment strategies. Current pre-clinical evidence estimating immune checkpoint inhibitors in several cancer cell lines has recommended that combinatorial approaches may have better survival results than monotherapy. Experimental trials evaluating combined therapy with anti-PD-1/ PD-L1 plus anti-CTLA-4 checkpoint inhibitors have reported considerable leads in survival indices over single immunotherapy. The therapeutic prospective of combinatorial approaches is focused on nivolumab with ipilimumab for advanced melanoma patients. Combined checkpoint inhibition with anti-PD-1/PD-L1 plus anti-CTLA-4 monoclonal antibodies is being estimated for broadly cancer histological...
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