Posted by admin on May 31, 2023 in |
Neurons are the nervous system’s basic components that involve the spinal cord and brain. Neurons do not usually replicate or substitute them because the body cannot replace them as they get impaired or die. Neurological conditions are untreatable and disabling diseases that result in irreversible deterioration/death of the human brain’s nerve cells or neurons. Treating these conditions with extended synthetic drug administration can lead to serious side effects. So, herbal therapy is preferable over traditional therapies. Using herbal remedies can provide significant potential benefits in preventing and treating Neurological disorders. Herbal medicines have been gaining much attention for their therapeutic value over many years. Herbal plants have been used to treat and manage various ailments from ancient times due to their economic availability and lesser side effects than conventional anti-parkinsonian drugs. The current review incorporates research on medicinal plants, which has demonstrated the ability to transcend the development of neurological disorders and highlights the significance of traditional plant species in the role and mechanisms involved in neuroprotection. Ayurveda is regarded...
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Posted by admin on May 31, 2023 in |
Background: The infectious disease, COVID-19, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is hardly showing signs of waning as it is still ongoing as a pandemic. Objective: To figure out potential leads from Ocimum sanctum and Plectranthus amboinicus’s phytoconstituents against SARS-CoV-2. Methodology: Selected phytoconstituents of O. sanctum and P. amboinicus were targeted on the PDB protein sequences of SARS-CoV-2 like 6W02, 4M0W, and 7T9L and were subjected to docking simulations using Pymol and the Autodock Vina tool of version 1.5.6. Hydrogen bond interactions and the amino acid residues of the targeted protein sequences were analyzed. ADME and drug-likeness predictions of the best dock-scored phytochemicals were further screened using the online tool molinspiration. Result: Out of 14 phytochemicals, only 9 had significant interactive profiles, of which Carvacrol, Eugenol, Apigenin, Luteolin, and Rosmarinic acid could potentially inhibit the targets of coronavirus. Only these five chemicals obey the ADME limitations and drug-likeness LogP values. Apigenin and Rosmarinic acid had better interactions at the active site of all three protein targets....
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Posted by admin on May 31, 2023 in |
The oral bioavailability of lumefantrine (LUMF) is low and erratic owing to its low aqueous solubility and P-glycoprotein (P-gp) mediated efflux. The present investigation aims to develop amorphous solid dispersions (SD) of LUMF co-loaded with piperine (PIP), a P-gp and CYP3A4 inhibitor, to improve its dissolution and thereby oral bioavailability. LUMF-SDs were prepared by using Polyvinyl-pyrrolidone, grade Povidone K30 (PVP) as a polymeric carrier, at three different ratios with increasing concentrations of polymer, employing melt method. DSC, XRD and FTIR characterized the PIP-LUMF-PVPSD at ratio of 1:6:18demonstrating higher aqueous solubility of LUMF. The DSC thermogram and XRD diffractogram confirmed the loss of crystallinity of both LUMF and PIP in PIP-LUMF SD, resulting in improved dissolution. Moreover, the possible molecular interactions between LUMF and PIP and /or PVP were investigated by FTIR studies. Crystallinity being a function of time, the stability of LUMF-PIP-PVP SD exposed to stressed humidity and temperature conditions (40 °C/75% RH) for 90 days was validated by DSC and release studies. These findings suggest that the SD...
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Posted by admin on May 31, 2023 in |
Millets are one of the oldest foods known to humans and possibly the first cereal grain to be used for domestic purposes. The Indian flatbread roti is made from ground millet seeds. In malice of all these extraordinary rates and capacities of millet husbandry systems, the area under millet products has been shrinking over the last five decades and swiftly after the green revolution period. The bitsy “grain” is gluten-free and packed with vitamins and minerals. Millet grain is largely nutritive with good quality protein, rich in minerals, salutary fiber, phytochemicals, and vitamins. The nutritional composition of the millet is compared with that of rice and wheat. Value-added products from millet have the eventuality to add value to the business and grow as consumers believe that millets and millet-predicated foods contribute directly to their...
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Posted by admin on May 31, 2023 in |
This study focuses on preparing and evaluating polymeric nanoparticles made of pegylated PLGA. In this study, both double-emulsion solvent evaporation and single-emulsion solvent evaporation were employed to formulate the pegylated PLGA nanoparticles with PVA as the surfactant. For the encapsulation of the hydrophobic drug Resveratrol, formulations were successfully prepared and tested for their particle size, polydispersity index, zeta potential, drug loading and entrapment efficiency. Scanning electron microscopy was used to observe the morphology and surface characteristics of the nanoparticles. The results demonstrated successful fabrication of the Resveratrol loaded pegylated PLGA nanoparticles. PVA was demonstrated in the present study to be a promising surfactant for the encapsulation and delivery of poorly water-soluble compounds as pegylated PLGA nanoparticles with the desired particle size, morphology and drug loading. PLGA nanoparticles encapsulated with Resveratrol had been successfully used to deliver the drug to the target site by pegylated PLGA...
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