Posted by admin on Apr 30, 2023 in |
Bhavaprakasha is Ayurveda’s important nighantu (Lexicon) written in the sixteenth century AD. Many useful herbs are mentioned in Bhavaprakasha Nighantu that can be used daily. However, one common misconception is that all ayurvedic drugs are safe and devoid of any side effects since they are of herbal origin is not true. Ayurvedic herbs sometimes become harmful based on the condition of the patient. The present review reports cautions and contraindications in administering certain herbs mentioned in Bhavaprakasha Nighantu for pregnant ladies and those who wish to conceive. Out of total of twenty-three Vargas (Classified groups), six vargas that is Harithakyadi to Amradi Phala varga of Chunekar commentary of Bhavaprakasha Nighantu were reviewed. Hareethakyadi, Karpooradi, Guduchyadi, Pushpadi, Vadaadi, Amradi Phala, comprising two seventy-nine herbs were reviewed critically with regards to their already mentioned action on conceived women and who wish to conceive from Bhavaprakasha Nighantu under four headings (1) Garbhasravakara / Garbhapathakara herbs (Abortifacients) (2) Garbhanirodhakara (Contraceptive) (3) Garbhashaya sankocha kara (Oxytocics) (4) Avrishya (Anaphrodisiac). Also more than a hundred...
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Posted by admin on Apr 30, 2023 in |
In mid-November 2021, the new OMICRON variety was first discovered in South Africa. As of today, the OMICRON version already appeared on December 15, 2021. Around 77 countries are affected, with the bulk of cases originating in the United States, India, the United Kingdom, and South Africa. OMICRON-positive instances were also reported. The first mortality associated with the novel COVID-19 mutation was reported in the United Kingdom. Recently, a sister variant of OMICRON, 21L or BA.2, has also been discovered. Due to its enormously high number of mutations, viewed enhancement in immune evasion and transmissibility, OMICRON was developed as a new variant of concern (VOC) by the WHO on 26 November 2021. On a global pandemic scale, positive selection of SARS-CoV-2 mutations appears to have begun in late 2020. Since then, the virus has been evolving on two fronts: immune evasion and enhanced transmissibility, as expressed by Delta. This review elaborates the effects of drugs in the management of...
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Posted by admin on Apr 30, 2023 in |
Hypercholesterolemia occurs when a high cholesterol level in the blood may lead to atherosclerosis. Scavenger receptor class B type 1 (SR-B1) is a protein found on the surface of various cells that facilitates the reverse cholesterol transport or efflux of cholesterol from peripheral tissues back to the liver. SR-B1 receives cholesterol from high-density lipoprotein (HDL), which is then transported and metabolized in the liver cells. In this study, the compound methyl benzoate isolated from Acanthaster planci was investigated for its ability to reduce hypercholesterolemia by increasing the expression of the SR-B1 gene. Using MTS assay, methyl benzoate showed a non-cytotoxic effect on hepatocellular liver carcinoma (HepG2) cells. The luciferase assay revealed that methyl benzoate increased SR-B1 promoter activity by 1.23-fold compared to the negative control. The expression of SR-B1 gene examined by real-time polymerase chain reaction (RT-PCR) increased the expression by 1.24-fold higher than that of the positive control. In addition, HDL uptake increased by 5% in the methyl benzoate-treated cells. As for the in-vivo model, methyl benzoate was...
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Posted by admin on Apr 30, 2023 in |
Incorporating the under-consumed super food ingredients rich in nutrients or functional compounds is a growing concern in healthcare product formulation. Health-ensuring cookies blend with Nelumbonucifera (Lotus) stem powder were standardized in the laboratory and found its acceptable form with comparatively higher acceptability and good flavour profile. Safety assurance is also a part of product development to assure and instruct the consumer regarding its life span or safe consumption time on storage duration. Therefore, the study further aimed at to- Aims and Objective: 1. To assess the quality of lotus stem cookies in terms of microbiological and organoleptic aspects. 2. To assess the impact of the growth of microorganisms in cookies prepared through blend of lotus stem powder. Methodology: Keeping quality of this formulated product has been assessed by enumerating the total bacteria, yeast and mould count in between a fixed time duration (0 – 90 days) and assessing its sensory qualities. AOAC (1994) suggested techniques (microbiological count assessment) and 9 point hedonic scale to observe the flavour profile were...
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Posted by admin on Apr 30, 2023 in |
Background: Pain is warning signal of the underlying pathology and is also essential for the diagnosis. Vanilla planifolia (VP) as per literature has analgesic activity. Analgesics like NSAIDs and Opioids are used for treating pain. Adverse effects limits their long-term use. Therefore, there is always a need of more effective and safe drugs. Objective: To evaluate the analgesic activity of ethanolic extract of Vanilla planifolia seeds. Material and Methods: Wistar rats weighing 150-200gms and mice 30-40 gms of either sex were included in the study. Hot plate model and acetic acid-induced writhing test was used. Animals were divided into four groups -Vehicle control, Standard control, VP Low Dose and VP High Dose. Drug treatment was given 1hr prior to the test & response to the thermal stimuli was noted on eddy’s hot plate. Drug treatment was given 1 h before and number of writhes was measured, at different time intervals 30 min up to 240 min after the injection of 1% acetic acid in writhing test. Data analyzed with...
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