Posted by admin on Mar 31, 2023 in |
The present study evaluated the bioactive components, antioxidant and anti-diabetic potential in the methanolic extract of edible Brotia costula. The identification of the sample was confirmed with the help of the DNA barcoding technique. The COI gene sequence was submitted in NCBI and obtained the accession number OM056887. Bioactive compounds present in the sample were evaluated and identified with the help of the Gas chromatography-mass spectroscopy (GC-MS) technique. The methanolic extract was tested for antioxidant capacity by its scavenging activity against Diphenylpicrylhydrazyl (DPPH), and its anti-diabetic activity was measured by the methanolic extract Alpha- amylase inhibition method. The GC-MS study revealed the presence of 76 bioactive components, and the compound with the highest peak area is phenol, 2, 4-bis (1, 1-dimethylethyl)-, phosphite. An inhibition percentage of 69.89 % in 500 μg against DPPH of the sample was observed as compared to 85.77% in ascorbic acid. The sample showed a good anti-diabetic potential with an inhibition percentage of 87.80 % in 500 μg of the sample. The findings of this...
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Posted by admin on Mar 31, 2023 in |
Aim: The current research aimed to formulate and evaluate herbal nanoemulsion of poorly soluble Berberine hydrochloride, which can provide a realistic alternative for treating microbial infections. Materials and Methods: The drug was characterized using various analytical techniques such as Ultraviolet Spectroscopy, Fourier transform infrared spectroscopy, and Differential Scanning Calorimetry study. The herbal nanoemulsion was prepared using the water titration method by constructing pseudo-ternary phase diagrams. Formulations were evaluated by thermodynamic stability studies, droplet size analysis, viscosity, drug content, refractive index, polydispersity, and in-vitro release study. Results: On the basis of the analytical study, no interaction between the drug and excipients was found. Based on visual observation nanoemulsion was optimized by using thermodynamic stability study and freeze-thaw cycle. The optimized nanoemulsion (NE-2) shows droplet size of 203.7 nm, Viscosity-94 centipoises, Zeta potential -19mv, polydispersity index- 0.366. The optimized formulation NE-2 shows 91.7% drug release in 24 hours and was further evaluated for antimicrobial activity using Bacillus subtilis and Candida albicans. The zone of inhibition was found to be 56.26± 1.78 mm for...
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Posted by admin on Mar 31, 2023 in |
Magnetic nanoparticles are hugely used in hyperthermia, targeted drug delivery processes, diagnosis, extraction, and cellular imaging of biological molecules, which can be widely used in cancer treatment. The focus of attention is on formation, features, types, made work, coating material, and therapeutic application of magnetic nanoparticles. It also pivots in safety and biocompatibility in magnetic nanoparticles (MNPs). Particles within the size range of nanoscale exhibit magnetic properties and are known as magnetic nanoparticles (MNPs). The major advantage of magnetic nanoparticles is the targeting at the specific site. Various polymerization and coating of metals can be done, such as applying chemotherapeutic drugs to correct inherited diseases. The various process of Magnetic Nanoparticles formation through diagrammatical picture is also discussed in this article. This review discusses the therapeutic application, preparation method, features of magnetic nanoparticles, types, made work, surface coating, biocompatibility, and...
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Posted by admin on Mar 31, 2023 in |
Background: Oral disintegrating tablets are strong dosage forms comprising medications that disintegrate throughout the oral cavity in less than 1 minute. Quality by designis a modern approach to pharmaceutical quality. Pharmaceutical Quality Design and discusses the use of Quality Design to maintain the quality of Pharmaceuticals. Methods: The frequent screening design, such as 32 factorial design, Box-Behnken, placket-Burman, optimization designs, 23 factorial design, and Central composite designs, including analysis of variance, are used. Conclusion: Quality by Design can be used to develop and evaluate methodological methods. Critical analytical variables are defined in an approach that is consistent with the process improvement referred to in ICH Q8 and Q9. This latest quality-by-design mechanism would incentivize even greater regulatory stability in the future. Formulations of Oral disintegration tablets were optimized with the help of quality by design. In the present article, an effort was made to review different screening designs employed in optimization formulations of oral disintegrating...
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Posted by admin on Mar 31, 2023 in |
This work compared the effect of hot aqueous extraction and blending on phytochemical content, AgNPs synthesis, antibacterial and antioxidant properties of ginger and turmeric. Qualitative and quantitative phytochemical screening was conducted on a hot aqueous extract of ginger and turmeric combination (CHAE) and blended ginger & turmeric combination (CBLE). An attempt was then made to synthesize silver nanoparticles by reducing 1mM AgNO3 solution with CHAE & CBLE, respectively. The biosynthesized AgNPs were characterized using UV-Visible spectroscopy, FTIR, and SEM. Using existing protocols, the antioxidant and antibacterial properties of CHAE, CBLE, and biosynthesized AgNPs were evaluated. The result of the phytochemical screening revealed the presence of phytochemicals required for synthesizing silver nanoparticles, such as flavonoids and phenols in CBLE but absented in CHAE. The UV-Visible spectrum confirmed the synthesis of AgNPs using CBLE (AgNPs-CBLE), with the highest absorbance peak observed at 412 nm. The FTIR analysis revealed the involvement of phenolic compounds in the bioreduction of Ag+ as well as the capping/stabilization of the biosynthesized nanoparticles. AgNPs-CBLE were irregularly granulated and...
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