Posted by admin on Feb 28, 2023 in |
Aegle marmelos, commonly known as Bael or Bilva, belonging to family Rutaceae, has been a tree of humongous significance since time immemorial. It has been used tremendously in ethnomedicine and ethnobotany owing to its spiritual connection. There are testimonials of its prolific use in Ayurveda, Unani and Siddha system of medicine. People also have found this tree of utility owing to its ecological and economic perspective. Almost all the parts of this tree are beneficial and have been used for various reasons. This research was undertaken to ascertain anti-anxiety and antidepressant responses in the hydroalcoholic leaf extract of Aegle marmelos employing the Elevated plus Maze for anxiety and Tail Suspension Test model for depression. Phytochemical screening of the prepared extract was also performed to recognize the phytochemicals possibly accountable for the selective psychotropic activities in the plant. A hydroalcoholic leaf extract using 50% ethanol was prepared and screened for presence of different phytochemicals and was found to comprise alkaloids, carbohydrates, flavonoids, tannins, saponins, terpenoids, coumarins, phenols, and reducing sugars....
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Posted by admin on Feb 28, 2023 in |
Frying is one of the oldest food processing methods. Its popularity is related to the ease and speed of food preparation and sensory characteristics, such as unique flavor and taste. Nowadays, the consumption of deep-fried food has gained popularity which causes an increase risk of different disease conditions such as obesity, cardiovascular disease, diabetes, hypertension, etc. So, the validation and standardization of fried foods commonly used in the household were more important. In this study, the Physiochemical and Organoleptic changes in repeatedly heated different types of oil such as sesame oil, coconut oil, groundnut oil, and refined Sunflower oil for preparing homemade popular South Indian snacks (Muruku) were studied. Density was found to increase gradually in peanut oil and refined sunflower oil. Viscosity was found to be stable in sesame oil. While the viscosity reduces in coconut oil, it increases in refined sunflower oil. The refractive index of the fresh and fried oil was found to be close enough to all the oils except refined sunflower oil, which had...
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Posted by admin on Feb 28, 2023 in |
To study reverse aging in Saccharomyces cerevisiae (S. cerevisiae) by gene expression analysis of target of rapamycin (TOR1) induced autophagy and replicative life span modelling (RLS) using Alpinia galangal (A. galangal), Commiphora mukul (C. mukul), Acorus calamus (A. calamus) and Morshella esculenta (M. esculenta). Methanolic extraction of plants was carried out using maceration. Activation of yeast was performed using the sugar fermentation method. Pharmacological anti-aging screens in yeast performed by RLS. Primers for Actin (ACT1) and TOR1 were designed using Primer-BLAST. Gene expression analysis (RNA isolation and quantification, reverse transcription, and real-time polymerase chain reaction) of TOR1 in S. cerevisiae was conducted using methanolic extracts. Phenolic and Flavonoid compounds were quantified using reversed-phase high-performance liquid chromatography (RP-HPLC). Cell counting and viability assessment of S. cerevisiae with trypan blueusing methanolic extracts was performed. Gene expression analysis results revealed under expression of TOR1 in S. cerevisiae with mean normalized expression ratios < 1 using all four methanolic extracts. Results from RLS showed increased absorbances due to decreased TOR1 activity. HPLC analysis...
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Posted by admin on Feb 28, 2023 in |
Rheumatoid arthritis is a systemic autoimmune and inflammatory disease that primarily affects the synovial joints and eventually destroys them. Schleichera oleosa is a plant of Indian provenance that exhibits anti-rheumatoid arthritis activity. The phytochemical constituents in the methanol extract of barks from Schleichera oleosa were identified using gas chromatography-mass spectrometry (GC-MS) in the current study. The GC–MS analysis in bark extract identified 21 phytochemical compounds. The PASS server assessed the biological activity of the reported compounds and identified six compounds with anti-arthritic and anti-inflammatory activities. Subsequently, these compounds were screened through ADME/Tox and molecular docking approaches. Two compounds 2,4-Di-tert-butylphenol and 2,6-DI-Tert-butylphenol qualify for all the criteria of ADME/Tox. The molecular docking method identified compounds 2,4-Di-tert-butylphenol and 2,6-DI-Tert-butylphenol had binding affinity ranging between -4.89 to -6.49 kcal/mol with the active site of anti-arthritic target proteins Chitotriosidase-1 and Vascular cell adhesion molecule 1. The findings of this study will create a way to invent herbal medicines for Rheumatoid Arthritis using the Schleichera oleosa plant, potentially leading to the development of new...
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Posted by admin on Feb 28, 2023 in |
The global market size was valued at $ 380.2 billion in 2019 and is projected to reach $463.5 billion by 2027, registering a CAGR of 5.3% from 2021 to 2027. Cosmetics have become an in-dispersible feature of the modern lifestyle. The use of cosmetics has increased in males and women in daily routine, which complements the growth of global cosmetic market demand. The skin care industries are trying to develop and market new and efficient products with advanced features that will affect appearance and therapeutic effects. The new development in cosmeceuticals has emerged in the form of Nanocosmeceuticals with the aid of nanotechnology in cosmeceuticals. Since, extrinsic factors like sunlight, dry weather, pollutants, stressful life, poor diet and inadequate sleep are leading to dull and diseased skin, nails and hair can be efficiently treated to get the good looking appearance, flawless complexion and blemish-free skin with the help of nanocosmeceuticals with various nanomaterials like liposomes, niosomes, transfersomes, cubosomes, ethosomes, dendrimers, solid lipid nanoparticles, nanoemulsions, gold nanoparticles, fullerenes, nanocapsules potentially...
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